4

Question 1

to find the overall net charge

Answer 1

add up net charge of all ionizable group
analyze ionizable group’s charge when de & protonated
%xcharge

Question 2

to find net charge of 1 group

Answer 2

1. Henderson Haselbach method
2. deproto A- will always be on top bcs A-/HA ‘
3. take % X charge or (de)proto / total (A- + HA)

Question 3

inverse of log

Answer 3

10 ^log

Question 4

describe the diagram

Answer 4

lower pK, more deproto => stronger acid
higher pK, more proto

Question 5

NH3+

Answer 5

deprotonated, neutral 0
promotnated, +1 charge
same with NH+ OR NH2+

Question 6

what is an amino acid

Answer 6

central a-carbon, R group, alpha amino and alpha carboxyl

Question 7

4 classes of ama

Answer 7

polar: - + uncharged and nonpolar

Question 8

the lower the pH the lower the concentration of H ions. T or F

Answer 8

F.

Question 9

nonpolar: list all am.a, 1, 3

Answer 9

GLAciers in ALA VALIantly Locate/ LEUcate Isolated/ILElated PROwlers
Glycine - Alanine - Valine - Leucine - Isoleucine - Proline
1: first letter Z

Question 10

ISOLEUCINE STRCUTRE

Answer 10

(am.ao CH- methyl (side) (down) C C

Question 11

proline structure

Answer 11

only 1 w/ ring structure
imino acid
can be hydroxylated
H
NH2+ – C – COOH
C C C

Question 12

describe polar (-)

Answer 12

ASPartic acid and GLUtamic acid: D & E respectively
carboxlyic acid

Question 13

what is a carboxylic acid

Answer 13

O = C -OH

Question 14

Valine (3 -1- structure)

Answer 14

VALI
V
CH w/ /2 methyls

Question 15

Leucine (3-1-structure)

Answer 15

LEU
L
CH2- valine

Question 16

describe polar positive

Answer 16

HIS Lost Kid Always Return
HIS/LYS/ARG
H L-K A-R

Question 17

structure of polar positive

Answer 17

Histidine: C w/ a pentose ring N NH+
lYSINE 4C NH3+
Arg: C C C NH
C– NH2 – NH2+

it covers NH+ NH3+ NH2+

Question 18

COMPARE methionine vs cysteine

Answer 18

METhodically Check the SULFUR
methionine vs cysteine
np vs polar uncharged
MET vs CYS (M C)
CCSC vs C–SH

Question 19

in the nonpolar mnemonic wha tis the ionizable

Answer 19

proline, NH2+
TYRosine, OH
Cysteine, SH

Question 20

explain Aroma of Fine PINE & Yellow Timber is Worth the TRP

Answer 20

PHE (F) vs TYR (Y) vs TRP (W)
alanine + aromatic ring vs only polar unchargede PHE with OH ionizable vs dpentose NH and aromtic