10: Inheritance Patterns

Question 1

Which type of inheritance pattern?

Sexes equally affected. Normal offspring will have normal children.

Answer 1

Autosomal dominant

Question 2

Which type of inheritance pattern?

Variable expression depends on how many mitochondria carry defect.

Answer 2

DNA disorder

Question 3

Which type of inheritance pattern?
Sexes equally affected. Newborn screening may pick up these disorders. Family hx usually negative except sibling may be affected.

Answer 3

Autosomal recessive

Question 4

Which type of inheritance pattern?

Two or more cell lines with differing genotypes in an individual.

Answer 4

Germline mosaicism

Question 5

Which type of inheritance pattern?

Only passed down via mother.

Answer 5

Mitochondrial

X-linked

Question 6

Which type of inheritance pattern?

Males have condition. Female carriers usually do not condition unless they are homozygous for the abnormal gene.

Answer 6

X-linked recessive

Question 7

Which type of inheritance pattern?

Proband has 2 copies of a chromosome from 1 parent and none from the other.

Answer 7

Uniparental disomy

Question 8

Which type of inheritance pattern?

Person with condition has at least 1 parent with condition.

Answer 8

Autosomal dominant

Question 9

Which type of inheritance pattern?

Both parents heterozygous for trait.

Answer 9

Autosomal recessive

Question 10

Which type of inheritance pattern?

Circular, double-stranded mitochondrial DNA defect. Not in nuclear DNA.

Answer 10

Mitochondrial

Question 11

Which type of inheritance pattern?
Generally major anomalies and multisystem problems. Sex chromosome disorders cause sterility and changes in growth patterns. Other changes may be more subtle.

Answer 11

Chromosomal abnormalities: Changes in number of chromosomes.

Question 12

Which type of inheritance pattern?

Consider if parents seem normal but offspring has an autosomal dominant condition.

Answer 12

Germline mosaicism

Question 13

Which type of inheritance pattern?

Changes may include deletions, duplications.

Answer 13

Chromosomal abnormalities: Changes in structure of chromosomes.

Question 14

Which type of inheritance pattern?
No clear biochemical or molecular defect. Considerable variation in expression. Both genetic and environmental components are important.

Answer 14

Multifactorial

Question 15

Which type of inheritance pattern?

Familial clustering. Sex difference in frequency.

Answer 15

Multifactorial