1: HTN Flashcards
What defines HTN
- Persistent clinical BP reading of >140/90
2. Ambulatory BP reading of >135/85
What are the types of HTN
- Essential (primary)
- secondary
- white coat
- malignant
What % of HTN is essential
95%
What % of HTN is secondary
5
Define white coat HTN
Clinical BP reading of >140/90. But an ambulatory BP reading of <135/85
Define essential HTN
HTN of unknown cause
What are the 3 aetiological categories of secondary HTN
Renal
Endocrine
Other
What % of renal HTN is due to intrinisic renal disease
75
What are the 5 types of intrinsic renal disease
Chronic pyelonephritis Systemic sclerosis Polyarteritis nodosa Adult polycystic kidney disease Glomerulonephritis
What % of renal HTN is vascular
25
What is the main cause of renovascular HTN
Renal artery stenosis
What are the 5 endocrine causes of HTN
- Cushing’s disease
- Pheochromocytoma
- Conn’s syndrome
- CAH
- Acromegaly
- Liddle’s syndrome
What are 2 other causes of HTN
Medications
Co-arctation of the aorta
What medications can cause HTN
Glucocorticoids MAOIs COCP NSAIDs Cocaine + Amphetamines
What is malignant HTN
Sudden increase in BP leading to vascular damage
What BP defines malignant HTN
180/120
What is the pathological hallmark of malignant HTN
fibrinoid necrosis
What are 3 non-modifiable risk factors for HTN
Age
FHx
Ethnicity
What are the modifiable risk factors for HTN
Obesity Diabetes Smoking Excess alcohol intake Excess caffeine intake High sodium diet Physical inactivity Psychological stress
How does HTN present clinically
Asymptomatic. Unless malignant
How can HTN present
Headache, visual disturbances, seizures
What is first-line Ix for HTN
Clinical BP reading - in both arms
If BP is high at the first measurement what should be done
Take a second measurement during the consultation
If someone has a clinical reading >140/90mmHg what should be done
ABPM
If someone has an ABPM of <135/85 what should be done
Nothing - they are normotensive
If someone has an ABPM of >135/85 what stage of HTN do they have
Stage I
If someone has an ABPM of >135/85 what should be done
If they are <80y AND have one of the following they should be treated
- Diabetes
- 10y cardiovascular risk of >20%
- Evidence of end-organ damage
- Renal disease
- Established cardiovascular disease
If someone has a BP of >150/95 what should be done
Treat, regardless of age and co-morbidities
If someone has malignant HTN what is first line
Sodium nitroprusside
If an individual has HTN and signs of papilloedema or retinal haemorrhage - what should be done
Refer to specalist same day
What is stage I HTN
Clinical BP: >140/90
ABPM: >135/85
What is stage II HTN
Clinical BP: > 160/100
ABPM: >150/95
What is stage III HTN
> 180/110
What is the justification for other Ix in HTN
To look for evidence of end-organ damage
What other investigations may be done in HTN and why
Opthalmoscopy - retinal haemorrhage U+E - renal damage Urinanalysis - renal damage ECG- IHD of LVH HbA1c - CV risk Lipids - CV risk
What is the lifestyle advice for someone with HTN
- Limit salt intake <6g/d
- Reduce caffeine
- Physical activity
- Reduce alcohol
- More fruit + veg
- Weight loss
If someone is <55 and NOT afro-carribean what should they be given first-line for HTN
ACEi
If someone is >55 or Afro-Carribean what is first line for HTN
Calcium channel blocker
What is second line for HTN
ACEi + Calcium channel blocker
What is third line for HTN
ACEi + Calcium channel blocker + Thiazide diuretic
If someones K+ is <4.5 what is given 4th line
Spirinolactone
If someones K+ is >4.5 what is given 4th line
Increase dose of thiazide
If individual does not respond to 4th line what should be done
Refer to specialist
What are 4 complications of HTN
- HTN retinopathy
- Stroke
- CVS disease - HF, IHD
- HTN nephrosclerosis
What is grade I HTN retinopathy
Tortous arteries with thick shiny walls
What is grade 2 HTN retinopathy
AV nicking
What is grade 3 HTN retinopathy
Flame haemorrhage and cotton wool spots
What is grade 4 HTN retinopathy
Papilloedema
How will HTN nephropathy present
microalbuminuria
How may HTN nephropathy present later
Nephrosclerosis and proteinuria