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MSK-1 Test 2 > 1. Fibrous Connective Tissue > Flashcards

1. Fibrous Connective Tissue Flashcards

1
Q

What is the potency of Embryonic Connective Tissue?

A

Multipotent

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2
Q

What organelles might a plasma cell have a disporportionate volume of?

A

Golgi Apparatus / Rough Endoplasmic Reticulum

(It produces and exports antibodies)

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3
Q

What is the name of umbillical embryonic connective tissue?

A

Warton’s Jelly

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4
Q

What are the 4 functions of white fat?

A

Energy storage, insulation, cushioning, hormone secretion

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5
Q

What is the lamina propria?

A

Loose connective tissue beneath membranous epithelia.

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6
Q

Where might elastic connective tissue be found?

A

In the walls of large arteries

Walls of bronchiole tubes

Special ligaments (eg Ligamentum Nuchae)

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7
Q

What makes the Extracellular Matrix in bone different from that in other tissues?

A

It is mineralized

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8
Q

What is Elastin assembled from?

A

Tropoelastin

Fibulin-1

Fibrillins 1 and 2

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9
Q

What are the three types of loose connective tissue?

A

Areolar

Adipose

Reticular

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10
Q

What can cause shallow breathing in COPD relating to connective tissue?

A

Elastin breakdown prevents the lungs from retracting fully to prepare for the next inhalation.

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11
Q

What are the fixed cells of areolar connective tissue?

A

Fibroblasts

Adipocytes

Mesenchymal Cells

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12
Q

What is the most common type of collagen?

A

Type 1

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13
Q

Besides the structural, what is the function of Extracellular Matrix?

A

Carries O2, CO2, Nutrients, and Wastes

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14
Q

What are the characteristics of brown fat?

A

Thermogenic

Abundant in newborns

Greatly reduced in adults

Contains abundant mitochondria

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15
Q

What is the function of Dystroglycans?

A

Linking the actin within the cell to the laminin outside the cell.

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16
Q

What is Ehlers-Danlos Syndrome?

A

A mutation in collagen synthesis and structure, leading to weak collagen fibers.

17
Q

Why might dense regular connective tissue heal slowly compared to other tissues?

A

It is poorly vascularized

18
Q

What does a deficiency of Vitamin C cause in connective tissue?

What is the basic mechanism?

A

Weakens CT

Vitamin C is necessary for cross linking of collagen fibers. Its deficiency leads to less cross linked collagen.

19
Q

What are Syndecans?

A

Strong coreceptors for growth factors on the cell membrane

20
Q

What connective tissue fiber is affected in Marfans?

A

Elastin

21
Q

What 5 things can Fibroblasts produce?

A

Collagen

Elastin

Proteoglycans

Glycoprotiens

Reticular Fibers

22
Q

What are the wandering cells of loose areolar connective tissue?

A

Macrophages

Mast Cells

Leukocytes / Lymphocytes

Plasma Cells

23
Q

What always separates connective tissue from the outside environment, in both the integument and the GI systems?

A

Epithelium

24
Q

What are the three types of dense connective tissue?

A

Dense regular

Dense irregular

Elastic

25
Q

How can you identify a Mast Cell over a Basophil?

A

Basophils have multilobar nuclei

26
Q

Chondroitin Sulfate, Heparan Sulfate, and Keratan Sulfates are all examples of what component of ground substance?

A

Proteoglycans

27
Q

What are the three functional types of Glycoprotiens in the ground substance?

A

Cytokines

Growth Factors

Structural Protiens

28
Q

What are the principal target systems for Marfans?

A

Ocular

Skeletal

Cardiovascular

29
Q

What gene is affected in Marfans?

A

Fibrillin 1 Gene (component of elastin)

30
Q

Where is dense irregular connective tissue found?

A

Dermis of the skin

Capsules of internal organs (eg kidney)

Perichondrium and pariosteum

Fascia

31
Q

What does reticular connective tissue do?

A

Forms a “chicken wire” cage to support and hold cells in place against gravity

32
Q

What is the principal cell type of dense connective tissue?

A

Fibroblasts

33
Q

What subunits are involved in collagen synthesis?

A

2x alpha type 1

1x alpha type 2

34
Q

What long molecule holds proteoglycans as branches?

A

Hyaluronan

35
Q

What do integrin receptors do as a basic function?

A

Allow cell to extracellular matrix interaction

MSK-1 Test 2 (18 decks)

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