1-24 Mechanisms of Antibiotics Flashcards
What is the mechanism of action and whether the agent is -cidal or -static:
Penicillin
B-lactam…target cell wall synthesis by irreversibly binding PBP and preventing cross-linking of peptidoglycan layer
-cidal
What is the mechanism of action and whether the agent is -cidal or -static:
Cephalosporins
B-lactam…target cell wall synthesis by irreversibly binding PBP and preventing cross-linking of peptidoglycan layer
-cidal
What is the mechanism of action and whether the agent is -cidal or -static:
Glycopeptides
Target cell wall synthesis by preventing cross-linking of peptidoglycan
-cidal
What is the mechanism of action and whether the agent is -cidal or -static:
Macrolides
Prevents protein sysnthsis (block formation of growing protein)
-static
What is the mechanism of action and whether the agent is -cidal or -static:
Tetracyclines
Prevent protein synthesis (block tRNA attachment)…not good for kids
-static
What is the mechanism of action and whether the agent is -cidal or -static:
Fluoroquinolones
Interfere with DNA supercoiling (ciproflaxin)
-cidal
What is the mechanism of action and whether the agent is -cidal or -static:
Aminoglycosides
Prevent protein synthesis
-cidal
What is the mechanism of action and whether the agent is -cidal or -static:
Sulfoamindes/trimethoprim
target two diff points in folate synthesis pathway…if used together it is bacteriocidal
Which class of antibiotics target cell wall synthesis?
Penicillins
Cephalosporins
Glycopeptides
Which class of antibiotics target/prevent protein synthesis?
Macrolides
Tetracyclines
Aminoglycosides
Which class of antibiotics interfere with nucleic acid synthesis/supercoiling?
Fluoroquinolones
Which class of antibiotics (that we covered in class) are mainly bacteriostatic?
Macrolides
Tetracyclines
What is the major function of Vancomycin
Vancomycin is a Glycopeptide and therefore disrupts cell wall synthesis.
Only effective against gram + organisms
The gram - bacterias are resistant due to LPS porons
a 34-year-old man recently diagnosed with streptococcal pharyngitis started a treatment with amoxicillin, two tablets daily. Which of the following statements best explains a prominent feature of the antibacterial action of this beta-lactam antibiotic?
Blocks the action of penicillin binding proteins preventing cross linking of the peptidoglycan sheets.
A 42-year old man recently diagnosed with pneumonia due to Klebsiella pneumonia was started on a treatment with fluoroquinolone (levoflaxacin), two tablets daily. Which of the following molecular actions most likely mediated the therapeutic effects of the drug in the patient’s disease?
inhibition of relaxation of supercoiled bacterial DNA
