1/2 micro, immuno and histo Flashcards
MOA of tenofovir
Nucleotide analogue
MOA of ritonavir
Protease inhibitor
MOA of entecavir
Nucleoside analogue
Telaprevir MOA
NS3/4 protease inhibtor
Ledipasvir MOA
NS5 protease inhibitor
Investigations for sporadic CJD
EEG- periodic triphasic complexes
MRI- basal ganglia and cortical increased signal
CSF- 14-3-3 protein, S100
DIAGNOSIS CONFIRMED ON BRAIN BIOPSY showing spongiform vaculoation and PrP amyloid plaques
What are familial prion disease
Fatal familial insomnia
Gerstmann-straussler strackman
All will present with family history of someone dying of MS, dementia etc
Live vaccines
Influenza under 18s
Yellow fiver
MMR
BCG
Heyerotypic vaccine
BCG- bacille calmette guerin
Toxoid vaccines
Diphteria
Tetanus
Conjugated vaccines
HIB
Pneumococcus
Meningococcal
Example of inactivated vaccines
Pertussis
Cholera
Hep A
Polio
Influenza for vulnerable populations
Examples of subunit vaccines
HPV
Hep B
Examples of viral vectored vaccines
Ebola
AZ COVID vaccine
Examples of M-RNA vaccines
Pfizer
Moderna
Complication of viral vectored vaccines
Vaccine induced thrombocytopenia and thrombosis
Capillary leak syndrome
Seen in AZ covid vaccine
Complication of pfizer vaccine
Myocarditis
Viral, bacterial, parasitic and amoebic cause of encephalitis
Viral- HSV, enteroviruses and western nile
Bacterial- listeria
Amoebic- naegleri fowleri
Parasitic- toxoplasmosis
What activates aciclovir by phosphorylating it and is responsible for the susceptibilty to resistance
Thymidine kinase
What is mechanism of resistance to antivirals in CMV
Protein kinase mutation
Second line for HSV
Foscarnet and cidofovir
Management of adenovir
Cidofovir
Treatment for different candida infections
Oral thrush- topical nystatin
Vulvovaginitis- topical clotrimazole or oral fluconazole
Localised cutaneous- topical clotrimazole
Oesophagitis- oral fluconazole
Management of cryptococcus
Flucytisine and amphotericin B