1-2 development of the nervous system Flashcards

1
Q

zygote

A

egg & sperm fertilize to create a zygote

46 chromosomes in 23 pairs

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2
Q

endoderm

A

precursor to organs, such as lungs & liver, & linings of the gut

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3
Q

mesoderm

A

precursor to bones, muscles, & blood

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4
Q

ectoderm

A

precursor to skin, eyes, & nervous tissue

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5
Q

nueral tube

A

precursor to CNS

cavity becomes the ventricular system of the brain

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6
Q

neural canal

A

center of the neural tube

ectodermal wall forms the rudiment nervous system

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7
Q

primary neuralation

A

cells of the neural plate invaginate & pinch off to form the tube

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8
Q

secondary neuralation

A

cells of the neural plate form a cord-like structure that migrates inside the embryo & hollows to form the tube

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9
Q

notochord

A

midline strip of cells between ectoderm & endoderm

component of mesoderm

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10
Q

neural plate

A

longitudinal band of ectoderm thickens to form the neural plate

neural plate border separates the ectoderm from the neural plate

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11
Q

dorsal induction

A

neural plate begins to fold inwards forming a longitudinal neural groove in the midline

neural groove deepens & neural folds approach each other toward midline

2 folds begin to fuse along neural groove

neural tube separates from ectoderm & becomes closed in the body

neural crest (from neural folds) separate from neural tube

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12
Q

sulcus limitans

A

longitudinal groove in the lateral wall of the neural tube

extends thru future spinal cord & brainstem & subdivides the gray matter in the walls of the neural tube into a alar & basal plate

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13
Q

alar plate

A

more dorsal

sensory processing

eventually becomes the cerebellum

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14
Q

basal plate

A

more ventral

motor processing

eventually becomes basal ganglia

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15
Q

neuropores

A

neural tube opening both cranial & caudally

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16
Q

neural tube defects

A

improper closure of the neuropores

rostral/anterior - anencephaly
caudal/posterior - spina bifida

17
Q

1st branchial arch

A

mandibular

CNV

lower lip, ant tongue, middle ear

mandible, maxilla, zygomatic, & temporal bones

muscles: mastication, mylohyoid, tensor tympani

18
Q

2nd branchial arch

A

hyoid

CNVII

stapes, stylhyoid, hyoid

muscles: facial expression, stylohyoid

19
Q

3rd branchial arch

A

CNIX, CNXII

hyoid

post tongue, epiglottis

muscles: stylophayngeus

20
Q

4th & 6th branchial arches

A

CNX

tongue, laryngeal cartilages, epiglottis

muscles: palatoglossus, pharyngeal constrictors, intrinsic larynx, esophagus

21
Q

myelination

A

brainstem (& cranial nerves) @ 18-24 weeks

myelination starts at 5 months & continues well after birth

myelination of central pathways - postnatal adolescence

22
Q

neural proliferation

A

starts at 5 weeks

generated in or close to the ventricular lining

cells divide & move either horizontal or vertical

23
Q

vertical cleavage

A

early stages of development

splits along vertical axis & produces 2 daughter cells

24
Q

horizontal cleavage

A

later development

splits along horizontal axis

only 1 of the daughter cells continues to proliferate

25
Q

nueronal migration

A

radial glial cells stretch from ventricular to marginal surface

neuralblasts migrate upwards

26
Q

cerebral cortex formation

A

formed of 6 layers of neurons

first layer to develop is layer 6 - the innermost layer