(09) Mastitis III Flashcards

1
Q

(69)

A
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2
Q

(70)

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(71)

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3
Q

(72)

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4
Q

(73)

(Mastitis - Secret to Success)

(Two Simple Steps:)

1-2. what are they?

A
  1. prevent new infections

(herd level control,

problem = many contributing factors)

  1. eliminate existing infections

(individual cow management (treatment, dry-off, culling)

problem = detection, therapeutic failure)

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5
Q

(74)

5-point Mastitis Control Plane – what is it?

A
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6
Q

(75)

(1. Post-milking Teat disinfection)
1. goal = ?
2. teat dipping reduces number of new infections by how much?
3. disinfectants?
4. key to success = ?

A
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7
Q

(76)

  1. pre-milking teat disinfection for what?
  2. post-milking teat disinfection for what?
A
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8
Q

(77)

(2. Universal Dry Cow Therapy)
1. best chance of cure for what?
2. options?

A
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9
Q

(78)

(Universal Dry Cow Therapy)

(The Significance of Dry Period Infections)

  1. what % of all new infections caused by environmental pathogens occur during the dry period?
  2. Over what % of clinical coliform mastits events in the first 100 days in milk originated during the dry period?
A

1 50-60%

  1. over 50%
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10
Q

(79)

(Universal Dry Cow Therapy)

(Blanket Dry Cow Therapy)

  1. intramammary infusion with long-acting antibiotic at dry off

(purpose)

  1. cure what?

3 prvent what?

4.

A
  1. cure existing subclinical infections
  2. new infections that could be acquired during the dry period
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11
Q

(80)

(Universal Dry Cow Therapy)

(Blanket Dry Cow Therapy)

A
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12
Q

(80)

(Universal Dry Cow Therapy)

(Dry Cow Therapy)

(internal test sealant (orbeseal))

  1. administred when?
  2. May not be economically jus)fied in herds with a very low incidence of new infec)ons over the dry period
  3. Does work to help prevent new infec)ons
A

1 at dry off - after IMM Abx

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13
Q

(84)

(5. Regular milking machine maintencance)

(Milking Machine)

  1. vector for what?
A
  1. bacteria

(dirty equipment, contaminated milk “impacts”)

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14
Q

(86)

(5. Regular milking machine maintencance)

(Milking Machine)

  1. Determinant of what?

improper vacuum and pulsation setting and over-milking –> ?

  1. Hyperkeratosis (difficult to clean, disrupted barrier to bacteria?)
A
  1. teat end health

teat end hyperkeratosis

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15
Q

(87)

(5. Regular milking machine maintencance)

(Milking Machine)

A
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16
Q

(88)

(5. Regular milking machine maintencance)

(Milking Machine)

A
17
Q

(89)

A
18
Q

(90)

A

(91)

19
Q

(92)

A

(93)

20
Q

(94)

(Pathogen Factors)

(Gram - vs Gram +)

(Gram Negatives)

  1. spontaneous cure rate?
  2. conventional thinking = ?

(Host-adapted gram-negatives)

  1. some gram negatives can act like contagious pathogens; survive in tissues for long periods, ineffective immune reponse (4.8-10%)
A
  1. high
  2. don’t need to treat
21
Q

(95)

(Pathogen Factors)

(Gram + vs. Gram -)

(Gram positives)

  1. most susc to what?
  2. Do you need to treat?
A
  1. beta lactam antibiotics
  2. YES - should treat most
22
Q

(96)

(Pathogen Factors)

(Pathogens have variable cure rates)

(staph aurues)

  1. rate?

(Strep Ag)

  1. rate?

(Non-ag Streps)

  1. rate
A
  1. low (20-30%)

(Degree of tissue invasion, B-lactamase major factors in possibility of cure)

  1. high (90-95%)
  2. intermediate (40-50%)

(some antibiotic resistance demonstrated)

23
Q

(97)

  1. Mycoplasma, Prototheca, yeasts

treament is what? why?

  1. A. pyo/trueperlla

treatment unsuccessful - why?

A
  1. unsuccessful - no target for antibiotics
  2. can’t penetrate abscess
24
Q

(98)

A
25
Q

(99)

A
26
Q

(100)

(Therapy Factors)

(Duration of Treatment)

  1. Does extended duration of therapy improve success of Staph Aureus treatment?
  2. also for what?
  3. could consider for other refractory cases
A
  1. yes (Pirsue - pirlimycin hydrochloride)
  2. strep uberis
27
Q

(101)

(Therapy Factors - Efficacy or Susceptibility)

(Label claims)

  1. only tell us what?
A
  1. what bugs were used to prove efficacy for FDA approval
28
Q

(102)

(Therapy Factors)

figure out how much of this you need to know

A
29
Q

(103)

(Therapy Factors - Efficacy or Susceptibility)

(Sensitivity testing)

  1. how useful?

why?

  1. OK to say one antibiotic MIGHT be better than another if what?
A
  1. almost totally useless

no cut-point data for mastitis pathogens, no demonstrated correlation to efficacy in the mammary gland, frequently misinterpreted

  1. one is susc and the other is resistant
30
Q

(104)

A

(105)

31
Q

(106)

DO IT

A