01- Derm Flashcards
embryological origin of dermis
mesoderm
what is the uppermost layer of the dermis?
papilloedema
what is the embryological origin of the epidermis?
mainly CD4/8 cells found here?
ectorderm → periderm ⇒ epidermis
CD8+ cells
what cells that aid in sensation are found between the keratinocytes and nerve fibres?
merkel cells
MHC 1 present endogenous/exogenous to CD8+ cells
endogenous
MHC2 cells present endogenous/exogneous to CD4+ cells
MHC 2 presents exogenous to CD4+ cells
which cells produce IFN alpha
plasmacytoid dendritic cells
what is the significance of IL-17A in psoriasis?
stimulates keratin proliferation
function of langerhans cells
produce liquid antigen and present to T cells
allergic contact dermatitis is what type of hypersensitivity?
hypersensitivity type IV
what is the brick and mortar model?
brick- corenocytes
mortar- intercellular lipids
which kind of drug in which vehicle will absorb best?
drug penetration is transcellular/intercellular
lipophilic drug in hydrophilic vehicle
drug penetration is intercellular
cream for pre-cancerous lesions?
aldara (imioquid)
equation for rate of absorption
KpxCv
list some anti-pruritics
menthol
capsaicin
mild to potent steroids?
hydrocortisone
mometasone
modrasone
clobetasol
lancefield class of strep pyogenes?
M1 & 3- predominant
M3 &18 cause severe disease
how to super antigens aboid detection?
MRSA super anitgen?
bind to MHC II on outside
TSST-1 toxic shock form MRSA
treatment of dermatophyte: small area
scalp
clotrimazole
terbinafine
describe haploinsifficiency
one gene cant produce the protein so you end up with less overall
what are the four kinds of itch and thier cause?
prurioceptive: somethign on skin
pyschogenic: delusion
neurogenic: drug cause
neuropathic: CNS damage
which layers are the following foudn in:
junctional naevus
intradernal naevus
compound naevus
DEJ
dermis
DEJ + dermis
define xeroderma pigmentosa
defect in NER gene resulting in photosensitivity leading to skin cancer
autosomal dominant condition resulting in multiple BCCs?
gorlins syndrome
what are ephilides?
freckles
what mutation occurs from UV damage to DNA
pyrimidine dimer mutation
what are the four kind of melanoma and which is the odd one out?
superficial spreadin
acral/nucosal lentignous
lentigo
nodular- grows vertically from outset (rest superficial first)
which is the most dangerous UV light?
UVC most lethal (blocked my Ozone)
then UVB
then UVA
what are the two most important virulence factors of strep pyogenes?
hyaluronic acid
CD44+ve
what causes necrotising fascitis type 1 and type 2?
type 1- anaerobes and coliforms
type 2- group A strep
what is the normal ABPI?
0.8- 1.3
low = vascular disease
high = calcification
