Zinc

Question 1

Considered

Sources with good bioavailability M, S, N

less bioavailable in G, L

absorption inhibited by

drugs such as

Answer 1

trace mineral

meat, shellfish, nuts

grains and legumes

dietary phytate, fiber, oxalate, Fe, copper

penicillamine, Na valproate, ethambutol

Question 2

Involved in synthesis/stabilization of

required for

Answer 2

DNA, RNA, proteins

normal spermatogenesis, fetal growth and embryonic development

Question 3

Deficiency in disorders such as

also common w

Chronic defic sx

In ME countries, assoc w

Answer 3

malabsorption, malnutrition, DM, cirrhosis, alcoholism, gastric bypass

dietary Zn def and inc dietary phytate

stunted growth in children, dec taste sensation, dec immune fxn

hypogonadism, dwarfism, hypopigmented hair

Question 4

Acrodermatitis enteropathica (AE)

inheritance

abnormality in

Gene mutation encoding

Breastfed infants presents

Answer 4

AR

zinc absorp

intestinal transporter for Zn uptake (dec Zn absorption)

after weaning, BM is high in Zn

Question 5

Clinical manifestations of AE

described as

Answer 5

diarrhea, periorificial and acral dermaititis, alopecia, FtT, muscle wasting, dec immune fxn

perioral/anal red scaly rash

Question 6

Acute toxicitiy

Mega doses causes sx such as

can interfere w

lead to

Intranasal zinc preps

Answer 6

low, tolerant

nonspecific GI

copper absorption, dec immune fxn

hypochromic anemia (Copper def)

avoid- damage nasal mucosa/anosmia