ziektes met targets

Question 1

Welk drug target Hooikoorts?

Answer 1

Histamine H1 receptor

Question 2

Welk subtype receptor Hooikoorts?

Answer 2

G-aq

Question 3

Welk signaling pathway hooikoorts?

Answer 3

G-aq >PLC >IP3 > Ca2+ mobilisatie

Question 4

Welke actie (hooikoorts)?

Answer 4

Antagonist

Question 5

FDA drug (hooikoorts)

Answer 5

Allerfree Claritine

Question 6

Welk drug target (parkinson)?

Answer 6

Dopamine 2 receptor

Question 7

Welke subtype (parkinson)?

Answer 7

G-ai

Question 8

Welk signaling pathway (parkinson)?

Answer 8

Remmen van adenylyl cyclase activiteit

Question 9

Welke actie (parkinson)?

Answer 9

Agonist

Question 10

FDA drug (parkinson)?

Answer 10

L-dopa

Question 11

Welke drug target (hartritme stoornis)

Answer 11

Beta-1-receptor

Question 12

Welk subtype (hartritme)

Answer 12

G-as (heteromeer G-eiwit)

Question 13

Welk signaling pathway (hartritme)?

Answer 13

Het opent L-type Ca kanalen/LTCC in plasmamembraan

Het zorgt dat adenylyl cyclase actief blijft > toename cAMP >PKA activeren > targets fosfolyeren

Question 14

Welke actie (hartritme)?

Answer 14

Antagonist

Question 15

FDA drug (hartritme)

Answer 15

Beta 1 blokkers

Question 16

Welk drug target (HIV)

Answer 16

b-chemokine receptoren

Question 17

Welk subtype (HIV)

Answer 17

CCR5 (celmembraan van lymfocyten)

Question 18

Welke signaling pathway (HIV)

Answer 18

Gi gekoppelde receptor: remmen van de adenylyl cyclase activiteit

Question 19

Welke actie (HIV)

Answer 19

Antagonist

Question 20

FDA drug (HIV)

Answer 20

Maravirac