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Moleculaire farmacologie > GPCR signalering > Flashcards

GPCR signalering Flashcards

1
Q

Wat doen G-eiwitten?

A

bepalen welke signalen van de pathways geactiveerd worden, wat leidt tot biologische effecten.

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2
Q

Wat doet G-as?

A

stimuleert adenylylcyclase> verhoogde cAMP vorming

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3
Q

Wat doet G-ai?

A

remt adenylylcyclase> vermindert cAMP vorming

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4
Q

Wat doet G-aq?

A

activeert fosfolipase C, verhoogt de productie van second messengers IP3 en diacylglycerol, waardoor calcium vrijkomt en dit activeert proteinekinase c, wat leidt tot samentrekking van de spieren

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5
Q

Wat doet G-a12/13

A

activeert Rho en dus rho-kinase > transport imuuncellen

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Moleculaire farmacologie (5 decks)

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