YSKT compile AS Flashcards
Patient has a fall and fractures hip. Cardiac problems, the fall was due to an MI, how do you manage?
Hemiarthroplasty, Dynamic hip screw, intramedullary device
57 year old male trips on pavement falls onto outstretched arm. X ray shows midshaft humeral fracture and osteolytic lesion on head of humerus. Fracture was opened and fixed. How would you describe this?
Pathological fracture due to mets
Pelvic X ray of osteoarthritis acetabulum, what do you do?
Total hip replacements
Patient has a fall and fractures hip - Extracapsular fracture (non special type). Cardiac problems, the fall was due to an MI, how do you manage?
Dynamic hip screw
Patient has a fall and fractures hip - Extracapsular fracture (reverse oblique, transverse or sub trochanteric). Cardiac problems, the fall was due to an MI, how do you manage?
Intramedullary device
Age <70 Patient has a fall and fractures hip - Displaced intracapsular fracture. Cardiac problems, the fall was due to an MI, how do you manage?
Internal fixation (if possible), hip arthroplasty if not
Osteopenia vs Osteoporosis
Male vs female Age (Younger = penia)
Patient has anatomical snuffbox tenderness and bait scaphoid fracture but no obvious signs on x ray. How do you manage?
Cast and return for x ray in 2-3 weeks
Parathyroid blood results: Raised calcium Raised PTH Low phosphate High ALP Serum Ca:Cr clearance >0.01
Primary hyperparathyroidism
Parathyroid blood results: Low/normal calcium High PTH High phosphate Low Vit D High ALP
Secondary hyperparathyroidism (gland hyperplasia)
Parathyroid blood results: Raised calcium Very raised PTH decreased or normal phosphate Normal/low Vit D High ALP
Tertiary hyperparathyroidism
Parathyroid blood results: High/normal calcium Normal/low PTH High phosphate Normal Vit D High ALP
Familial hypocalciuric hypercalcemia
Jaundice in first 24 hours - cause? Mother is O+ve?
ABO incompatibility
Jaundice in first 24 hours - cause? Mediterranean/African Americans/ Middle Eastern Male infant
G6PD deficiency
Jaundice in first 24 hours - cause, FH and spherocytic blood film
Spherocytosis
Jaundice in first 24 hours - Mother was infected during pregnancy Treat?
Growth restriction Hepatosplenomegaly TTP (Congenital infections) Exchange transfusion
Parathyroid blood results: High Calcium Normal/low PTH Low phosphate High ALP
Parathyroid malignancy
Child presents with bruising, high lymphocytes
ALL
Child presents with bruising, high lymphocytes Reddish purple dots on the ankles and feet (petechia)
Immune Thrombocytic Purpura
Child with purpuric rash Bloody diarrhoea and abdo pain Rash on buttocks, legs and feet
Henloch Schonlein purpura
Child with purpuric rash + splenomegaly
ALL
Back pain with irregular prostate, and urinary symptoms
Prostate cancer
Solid mass on liver imaging, diabetes, women taking estrogen-containing oral contraceptive medication - 4cm, vascular?
Hepatic adenoma
Alcoholic patient with solid mass on liver imaging - 4cm, vascular?
Hepatocellular carcinoma
Cancer patient presents acutely with cord compression?
1) Steroids - Dexamethasone 2) MRI spine and review
Round opacification of paediatric XR
Pneumonia
Paediatric non accidental injury
Bruising on back Mid-shaft transverse femoral fracture
APGAR score 0-3 management?
ABCDE on baby High flow O2 Adrenaline Compressions Monitor glucose
Renal artery stenosis imaging?
Angiography
How to prevent diabetic nephropathy progression in long term diabetic?
ACE-i to stop progression according to BMJ BP Keep BP below 130/80
Patient presents 38 weeks pregnant - bp 140/90 and protein ++ Diagnosis? Management?
Pre-eclampsia Deliver the baby
Patient presents 35 weeks pregnant - bp 140/90 Diagnosis? Management?
Gestational hypertension B-blockers - labetalol
When to give oxytocin in 3rd stage of labor?
10iu of oxytocin as anterior shoulder of baby is out and then double clamp cord -in delay of clamping cord= higher haematocrit levels in neonates
What is the gold standard investigation for endometriosis ?
Laproscopy
How do you prevent diabetic proliferative retinopathy?
Laser treatment
What is the scoring system ABCD2 used for?
TIA Age: >/= 60 =1 BP: >/= 140/90=1 Clinical features: -unilateral weakenss= 2 -speech impairment without weakenss= 1 Duration: >/= 60min= 2 10-59min: 1 Diabetes= 1
What is the management of ABCD2 score >4?
carotid imaging within 24hrs of initial assessment -CT/ MRI
What is the management of ABCD2 score 0-3?
Need other indication for hospital observation
6wks pregnant woman with light bleeding, HCG 650, and TVU showing no fetus?
miscarriage
6wks pregnant woman with light bleeding, HCG 100,000, and TVU showing no fetus, intrauterine mass with small cystic spaces (honeycomb)?
Hyaditiform mole (complete)
6wks pregnant woman with vaginal bleeding, shoulder tip pain, abdominal pain, bHCG >1500
Ectopic pregnancy
6wks pregnant woman with light bleeding, HCG 100,000, and TVU showing fetal tissue?
Hydatidiform mole (incomplete)
What are varicose ulcer signs?
Lipodermatosclerosis, swollen, achy legs, shallow red sore with irregular edges
What is the management of aspiration pneumonia in post stroke + swallowing problem patient?
SALT referral Metronidazole
BPH + LUTS management?
tamsulosin + finasteride
Patient jaundice, fever, RUQ pain?
Ascending cholangitis (Charcot’s triad)
What is the ix for 51yr-old woman, 14 months amenorrhoea, hot flushes?
menopause- none
What is the ix for 42yr-old woman, 14 months amenorrhoea, hot flushes?
FSH
33 year old comes for random test - has +ve RF but no sx?
Doesn’t have RA
33 year old comes for random test - has +ve RF, +ve anti-CCP, but no sx
RA
33 year old comes for random test - has +ve ANCA, CRP, ESR
Most likely connective tissue disorder
SLE with Antiphospholipid syndrome, what do you need to warn them about ?
Miscarriage
Patient comes in with fever with new heart murmur? Treatment?
Infective endocarditis Flucloxacillin + Gentamicin
What’s Duke criteria used for and what does it consist of?
Infective endocarditis Major: +ve blood culture evidence in ECHO Minor: predisposition (IVDU, previous heart) fever microbiology vascular phenomenon (janeaway lesions, etc)
Patient been on sertraline for 18 months, not getting on with it, what is the next management?
Switch to other SSRI (fluoxetine)
Patient with migraines, experiencing them 2x a week, stressed with new job - what would you start?
Acute: triptan + NSAID/paracetamol Prophylaxis: propanolol
Pt with severe unilateral headache, especially around one eye, lacrimation ?
Cluster headache
What is the immediate and prophylaxis management of cluster headache?
Acute: 100% O2 + subcut triptan Prophylaxis: verapamil
Patient with Phalen’s sign, thenar wasting, weakness of thumb?
Carpal tunnel
Cyclist comes in with hypothenar wasting, tingling of fourth and fifth finger?
Guyon’s canal syndrome; ulnar nerve entrapment
Presentation in anorexic patient that requires hospitalisation?
BMI <13 or >1kg/ week amenorrhoea abnormally low potassium abnormally low temperature infection of any kind HR <40bpm
Bulimia vs AN?
Bulimia= normal BMI -more impulsive than AN -weight fluctuation -parotid hypertrophy (sialadenosis)
What is the presentation of patient with Bipolar that stopped taking medication?
anxiety, mania, headaches, pressured speech, irritability, depression
Section 2 Used for? Recommendation? Apply? Duration?
Used for assessment Two Section 12 doctors or One section 12 patient’s GP Apply by nearest relative or AMHP (health professional) 28 days –> Discharged or convert to S3 (Patients can appeal in first 14 days)
Section 3 Used for? Recommendation? Apply? Condition? Duration?
Used for treatment Two Section 12 doctors or One section 12 patient’s GP Apply by nearest relative or AMHP (health professional) Appropriate treatment available of condition or protect public Duration is 6 months –> Elongate or discharge (Patients can appeal once every 6 months)
Section 4 Recommendation? Apply? Condition? Duration?
Emergency admission by any doctor Apply by nearest relative or AMHP (health professional) Mental disorder Duration 72 hours –> Discharge, convert to S2/3, Elongate (can’t appeal)
Section 5(2) Recommendation? Apply? Condition? Duration?
Emergency of detention of information patient Doctor in charge of patient No application Mental disorder Duration 72 hours –> Discharge, convert to S2/3, Elongate (can’t appeal)
Section 5(4) Recommendation? Apply? Condition? Duration?
Emergency of detention of information patient Nurse in charge of patient No application Mental disorder Duration 4 hours –> Discharge, convert to S5(2), Elongate (can’t appeal)
Section 136 Recommendation? Apply? Condition? Duration?
From public place police powers to remove to place of safety (A&E, police station) someone who appears to be suffering from a mental disorder 72 hrs requested by AMHP and granted by magistrate
Section 35
remand for hospital for assessment
Section 36
remand to hospital for treatment
section 48/49
transfer of a remanded prisoner from prison to hospital
section 37
hospital order
section 37/41
hospital order with restriction order
section 47/49
transfer of a sentenced prisoner to hospital for treatment
Section 17a
supervised community treatment -compulsory treatment for community patients -apply to patients under section 3 -last for 6 mths
Patient with post op, PE and calf swelling. What is the best IX?
CTPA
8 year-old that need emergency appendectomy, comes with patient. Can child consent? If not, who can?
Child cannot consent because Gillick non-competent; grandparents do not have parental decision making Can act on patient’s best interest (Beneficence)
2-3 week history of feeling tired/ill, in last few days suddenly urine output drops, haematuria, proteinuria, bp is normal: what is cause?
post-strep glomerulonephritis
3 day history of feeling tired/ill, in last few days suddenly urine output drops, proteinuria, bp is normal: what is cause?
membranous
What are the symptoms of avoidant PD?
AFRAID Avoids social contact Fears Criticism Restricted lifestlye Apprehensive Inferiority Doesn’t involve unless sure of acceptance
What are the symptoms of dependent PD?
SUFFER Subordinate Undemanding Feels hopeless when alone Fears abandonment Encourages others to make decisions Reassurance needed
What are Cluster A PD?
paranoid, schizoid, schizotypal
What are Cluster B PD?
antisocial, borderline, histrionic, narcissistic
What are Cluster C PD?
avoidant, OCD, dependent
What are the symptoms of paranoid PD?
SUSPECT Sensitive Unforgiving Suspicious Possessive and jealous Excessive self-importance Conspiracy theories Tenacious sense of rights
Squamous cell carcinoma arises from?
Arises from actinic keratosis (pre-cancer)
Rx for VZV in pregnant woman?
IVIG immediately
Ulnar neuropathy first line Ix/
EMG/NCS
What are the developmental milestones for 2.5 yrs old?
use 250 words walk, run, turn doorknob, selfish and self-centered
Chinese guy with conductive hearing loss?
nasopharyngeal carcinoma
What are the croup ddx?
epiglottis foreign body peritonsilar abscess
What is the acute management of mild/moderate asthma?
nebulise salbutamol
What is the presentation of opiate/ heroin withdrawal?
sweating, muscle aches, sleep problems, runny nose, irritability -later: dilated pupils, vomiting, diarrhoea, abdo pain, tachy/brady, cramping goose bumps
Which feature of CTG implies fetal hypoxia?
late deceleration
What are the presentations for acoustic neuroma?
vertigo, unilateral hearing loss, tinnitus, absent corneal reflex, facial palsy MRI of CPA
What are the common symptoms peripheral vascular disease in diabetics?
Venous ulcer
Patient comes in with ear pain, itch and discharge. Otoscopy shows red, swollen canal. What is the management?
Otitis externa Hydrocortisone Rx: topical antifungal (clotrimazole)
DVLA laws for stroke patient?
6months
DVLA laws for epilepsy?
12 months since last seizure
11yr-old girl with 3mths hx of abdo distention, weightloss, no blood or mucus in stool, mouth ulcers and dermatitis herpetiformis?
Coeliac
11yr-old girl with 3mths hx of abdo distention, loose, watery stools after drinking milk?
Lactose intolerance
11yr-old girl with 3mths hx of bloody diarrhoea, urgency to defacate, tenesmus?
UC
11yr-old girl with 3mths hx of recurrent diarrhoea, abdo pain, delayed puberty, and malnutrition?
Crohn’s
Patient comes in with generalised weakness, leg cramps and nausea?
HHS (hyperosmolar hyperglycaemic state)
What does endomysial and anti-gliadin indicate?
Coeliacs
What are the signs for Parkinson’s disease?
TRAPD Tremor Rigidity Postural instability bradykinesia
What are the signs of community acquired pneumonia?
increased vocal fremitus
Sudden chest pain Increased JVP SOB Low BP Tachypnea Discomfort relieved by sitting or leaning forward
Cardiac tamponade
What are the signs of community acquired pneumonia?
Increased vocal fremitus
What are the signs of Hospital acquired pneumonia
Decreased vocal resonance
How does gout present in a 60 old year old hypertensive who has had it for 2 years?
Cyclical flares of joint pain, swelling and erythema 12 hours - several days (Predisposed by diuretics)
Treatment for glaucoma?
Medical - pilocarpine Surgical - Iridoplasty
Treat oligomenorrhoea in patient with BMI 30 with PCOS who desires fertility after advising weight loss?
Metformin
Meningitis CSF - Clear Normal pressure Lymphocytes mostly Normal glucose High protein PCR-assay
Viral
Meningitis CSF - Cloudy Pressure increase Neutrophils Decreased glucose High protein Gram stain culture
Bacterial
Meningitis CSF - Opaque High pressure Mostly neutrophils Decreased glucose High protein Acid fast bacillus stain PCR
TB
Meningitis CSF - Clear High pressure High lymphocytes Decreased glucose Moderately high protein India ink stain
Cryptococcal
MS patient on low dose baclofen, not experiencing side effects. How would you treat her pain?
Increase baclofen
Bilateral conjunctivitis + itchy eyes
Topical antihistamines
Patient is delirious with diagnosis 80. Squamous cell lung cancer with liver mets diagnosed?
Hepatic encephalopathy
Patient in Ventricular Tachycardia arrests?
DC cardiovert Stable – pharmacological cardioversion with Amiodarone, Lidocaine, Procainamide
Patient has fit, seen to have jerking movements, loses continence and bites tongue - what is it?
Generalised tonic clonic seizure
Endometrial cancer, what type of cancer is it?
Adenocarcinoma
Patient with weight loss, dysphagia and occult blood - next investigation?
Upper OGD
Dyskaryosis
Multi nucleation Increased cytoplasm:nucleic ratio
Patient presents, after vomiting for past few days, with a little bleed - cause?
Mallory Weis tear
Dyskaryosis
Multi nucleation Increased cytoplasm:nucleic ratio Irregular chromatin distribution Hyperchromasia
Hep B Immune marker to indicate Hepatitis division/multiplying
HbsAg
COPD on Salbutamol and comes into clinic, breathless, FEV <40% (acute) - management?
Salbutomal and Ipratropium Nebulised and Prednisolone
COPD on Salbutamol and comes into clinic, breathless, FEV <40% (chronic) - management?
Oral pred ICS
Psoriasis question, gentleman doesn’t want to take anything oral, which of options has good evidence?
Topical corticosteroid
Baby with asymmetrical gluteal creases, what investigation do you do?
Ultrasound Developmental dysplasia of the hip
Baby with asymmetrical gluteal creases, what investigation do you do?
Ultrasound and then hip XR Developmental dysplasia of the hip
Psoriasis question, gentleman doesn’t want to take anything oral, which of options has good evidence?
Topical corticosteroid (mild) Phototherapy (moderate to severe)
Patient had depression, had core symptoms + extras - 6 in total - Management?
Antidepressant (Sertraline) + CBT
Girl with primary nocturnal enuresis - First line management?
Behavioural
Progressive hip pain (over weeks), Limp, stiffness and reduced range of movement in 7 year old, trendelenburg +ve - Diagnosis?
Perthes disease
What symptom most likely to be found in meningococcal septicaemia?
Non-blanching rash
Patient post stroke, has IT job and 5th floor flat with lift. Has quite a few problems. - what would you do?
Full OT assessment and home visit before discharge
Patient wanted contraception. When is it advised to start?
First day of period
Melanoma - key factor for prognosis?
Thickness (depth)
Patient with hx of macular degeneration was agitated and delirious but was not a threat to anyone - how would you manage?
Reassurance patients Reduce noise and distraction (Side room)
XR of colles fracture
Horizontal across radius
Imaging ACL tear
MRI
Patient with osteoarthritis - mild sx and managed with analgesia. How would you manage?
Physiotherapy
Open fracture of tibia - how do you manage?
Abx & dress
MS relapse management ?
IV methylprednisolone
Woman BMI>40 and previous macrosomic baby - when do you test for GDM in pregnancy?
28 weeks
Epistaxis management after pressure attempted, what next?
Packing (children/not well tolerated) Cauterise sphenopalatine
Acne treatment causing blue patch?
Minocycline
CT show calcification in alcoholic patient?
Chronic pancreatitis
Teenager RTA with bruising on the chest and hypovolaemia. Resp exam is ok - first step?
Cannula Bloods - FBC, U&Es, crossmatch, clotting Fluid resus
Child with red rash on Flexor aspects of elbows and on wrist
Atopic eczema
NSTEMI with normal troponin
Unstable angina
2 week of haematuria post URTI
Post Strep Glomerulonephritis
Peripheral artery disease management
Quit smoking Atorvastatin Clopidogrel Endovascular revascularisation
ADHD - what would aid in the diagnosis?
Report from the teacher
Most common cause pyelonephritis
E.Coli
Painful eye movements, Swollen fingers + eosophageal
Myasthenia gravis
Contraception for adolescents
Gillick competencies Under 16s having sex call police Recommend the use of condoms both as a contraceptive, and to prevent sexually transmitted infections (STIs).
Cause of Intermenstrual bleeding in woman with COCP
Missed COCP pill Alternative remedies taken Clotting drugs Tamoxifen Cervical pathology, vaginal or uterine causes Smear tests
Everything normal pretty much and endometrial tissue is 5mm in woman with bleeding
Dysfunctional uterine bleeding
Rheumatoid arthritis lung changes
Both restrictive and obstructive (fibrosis)
Endometriosis symptom most indicative
Deep dyspareunia
Most common cause of Pelvic Inflammatory Disease
Chlamydia Gonorrhoea
What to do before inducing labor
Cervical sweep
Haematuria 1 year ago, then painless haematuria
Renal cell carcinoma
Painless jaundice ddx
Pancreatic cancer
Necrotizing enterocolitis biggest risk factor
Preterm
Commonest cause of preterm babies
Pregnancy with multiple babies Hx of preterm labour/birth Infection Diabetes/HTN
Subfertility, cycles 35-48 days, causes of why she can’t get pregnant?
Smoking
Kid wanted to sleep but couldn’t due to rash
Eczema (itching at night)
Wife has manic symptoms on a background of depression, currently on SSRI, what do you do?
Bipolar Stop SSRI, swap to Lithium
Management of PTSD
Watchful waiting for mild symptoms Trauma focussed CBT Severe - Eye movement desensitisation and reprocessing (Paroxetine if drugs being used)
Management of OCD
CBT SSRI
Diagnosis of asthma
Reversibility
18m old child, can’t walk, crawls. Alert to strangers - where is delay?
Gross motor delay
Fraser guidlines
- He/she has sufficient maturity and intelligence to understand the nature and implications of the proposed treatment 2. He/she cannot be persuaded to tell her parents or to allow the doctor to tell them 3. He/she is very likely to begin or continue having sexual intercourse with or without contraceptive treatment 4. His/her physical or mental health is likely to suffer unless he/she received the advice or treatment 5. The advice or treatment is in the young person’s best interests.
What is the most common injury with anterior dislocation of shoulder?
Axillary nerve and artery 95% Presentation in examination: humeral head visible, flattened deltoid
What are the causes of anterior shoulder dislocation?
falling in outstretched arm
RTA patient with open book fracture pelvis, scaphoid fracture. stable but absent bowel sounds?
ABCDE and then CT TAP Internal fixation
Management for Open comminuted fracture of tibia?
wash out in theatre and give abx immobilise, IV ABx, tetanus vaccine (everyone gets, if not fully immunised–> 3 vaccines and 2 boosters 10 years apart), debride and lavage, fixation if indicated
Management of Cervical spine fracture, developed neurological symptoms?
immobilise + analgesia and immediate neurosurgical referral + IV methlyprednisolone
Management of Cervical spine fracture with pain?
NSAID and Follow Up can add temporary opioid
Sensory lost on medial 1 and a half finger, where is the lesion?
cubital tunnel syndrome
Pronounced claw hand and motor symptoms, normal back of hand sensation?
guyon’s canal syndrome
Man, smoker, alcohol drinker, lost weight. Picture of a lesion at the back of the throat?
Squamous cell
Numbness half face, post nasal drip and other signs, when is the investigation is most appropriate: Nasal endoscopy? CT? MRI?
Considering CSF leakage OR cancer CT Scan is good for identifying breaks in bones/skull or if cancer has spread to bone. MRI is better to see the type and size of the cancer
Sensorineural hearing loss (unilateral), tinnitus, headache, CN palsies (trigeminal/facial/vestibulocochlear nerve), vertigo (late sign), signs of raised ICP Diagnosis? Investigation?
Acoustic neuroma (vestibuloschwannoma) MRI brain - gadollinium enhanced
Complications of cataract surgery?
Posterior capsule opacity (PCO) Intraocular lens dislocation. Eye inflammation. Light sensitivity. Photopsia (perceived flashes of light) Macular edema (swelling of the central retina) Ptosis (droopy eyelid) Ocular hypertension (elevated eye pressure)
Diabetic proliferative retinopathy and macular oedema in one eye. How best to manage?
Anti-vegf injection +/- panretinal photocoagulation (if significant then photocoag first then, intravitreol anti vegf, macular laser)
Patient has anterior uveitis. What medication is contraindicated?
Pilocarpine - irritates ocular surface
Patient with renal transplant, lesion on lip - diagnosis?
Immunosuppression due to the transplant -> increased risk of SCC.
Prodromal fever and malaise. Lesions start on the head, then spread to trunk and peripheries. Lesions as papules → Vesicles → Pustules → Crusting Diagnosis? Treatment?
Analgesia and go home
Occasional barking cough and no audible stridor at rest. No or mild suprasternal and/or intercostal recession. The child is happy and is prepared to eat, drink, and play.
Mild croup
Frequent barking cough and easily audible stridor at rest. Suprasternal and sternal wall retraction at rest. No or little distress or agitation. The child can be placated and is interested in its surroundings
Moderate croup
Management of croup
Single dose of oral dexamethasone (0.15mg/kg) to all children regardless of severity - prednisolone is an alternative if dexamethasone is not available - Advise paracetemol or ibuprofen for fever/pain Emergency treatment ● high-flow oxygen ● nebulised adrenaline
Frequent barking cough with prominent inspiratory (and occasionally, expiratory) stridor at rest. Marked sternal wall retractions. Significant distress and agitation, or lethargy or restlessness (a sign of hypoxaemia). Tachycardia occurs with more severe obstructive symptoms and hypoxaemia.
Severe croup
Acute asthma, already on salbumatol nebs and steroid, no improvement, what do you give next?
- Oxygen (if <94%) 2. Salbutamol - also consider IV 3. Ipratropium bromide 4. Oral steroids = prednisolone 3-5 days 5. Aminophylline/theophylline (OSHIMT) Magnesium sulphate IV is an adjuvent that can be given if no response after step 4.
Asthma not well controlled, told about a wheeze and other signs. What would you like to know next?
Peak flow
Downs, healthy at birth no cardiac signs. Parents have been told of complications. What do you do next?
Echo
Down syndrome with failure to thrive
Coeliac disease
Down syndrome conditions risk
- An abdominal x-ray is indicated in infants with DS, as they may be born with a GI defect such as duodenal or anal stenosis, or duodenal or anal atresia (30%). - Hearing screen and thyroid tests are required in all newborns in general. - Vision should be examined in the newborn period because some infants with DS are born with ophthalmic problems. - Haemoglobin for anemia - Dental due to caries - Obstructive sleep apnea
Malaysian girl, persistent jaundice (>2 weeks), yellow/brown urine, pale stools, hepatosplenomegaly after 3rd/4th week. High conjugate bilirubin Diagnosis?
Biliary atresia (rare) → absence of bile ducts. (Immediate Kasai procedure hepatoportoenterostomy → Drain bile) Ddx - neonatal hepatitis
Causes of prolonged jaundice in newborns
Biliary atresia Hyperthyroid Galactossemia UTI Breast milk jaundice (unconjugated bilirubin) CMV/Toxoplasmosis
Has had 2 vasoocclusive crises in a Sickle Cell Disease patient. Also takes penicillin, spleen enlargement with abdo pain + circulatory collapse. What treatment is best?
Splenectomy
Patient has vasoocclusive crisis in a SCD patient. Also takes penicillin, 1cm palpable spleen. What treatment is best?
Hydroxyurea (prevent future crisis) Acutely - NSAIDs, antihistamine
Child misbehaving at home, but fine at school. What meds will help?
Nothing ADHD is worse in school
Newborn sob, grunting, 6 hours after birth. Normal delivery, was fine before. What is likely cause?
Acute respiratory distress syndrome
Menorrhagia treatment - 1st line? 2nd line?
1st line: Mirena Coil (IUS) 2nd line: Tranexamic Acid (or if want kid)
41 week gestation, unremarkable pregnancy, 2cm dilated, station 0, cervix position anterior, soft consistency, almost fully effaced. What do you do?
Membrane sweep Intravaginal prostaglandins Breaking of waters (amniotomy with amnihook) Oxytocin
41 week gestation, unremarkable pregnancy, 2cm dilated, station 0, cervix position anterior, soft consistency, almost fully effaced. What do you do?
Membrane sweep Intravaginal prostaglandins If doesn’t work: Do CTG monitoring Breaking of waters (amniotomy with amnihook) Oxytocin
What is Bishop score used for and what does each mean?
Assess the necessity of induction in prolonged pregnancy (>12days after EDD or 41 (+3)) <5= induction 5-9= ARM >9= spontaneous labour Call PEDS C: consistent P: position E: effacement D: dilatation S: station
Indications for induction of labour?
-prolonged pregnancy (>12 days EDD) -prelabour premature rupture of the membranes without labour starting -DM mother >38weeks -Rh incompatibility
What are CI for induction of labour?
-acute fetal compromise -abnormal lie -placenta praevia -pelvic mass/deformity -cephalopelvic disproportion
What medication for induction of dead fetus?
Misoprostal
Lady positive pregnancy test (7weeks) , LIF pain and bleeding, what is most appropriate investigation?
TVUS
Lady positive pregnancy test (<5 weeks) , LIF pain and bleeding, what is most appropriate investigation?
quantitative serial b-HCG
Patient has pcos. What investigative ratio is most suggestive of diagnosis?
testosterone/ SHBG –> baseline test for evaluation of hyperandrogenism
What is the best ix to rule out causes of oligomenorrhoea/ amenorrhoea in PCOS?
LH/FSH ratio
Risk factors for gestational diabetes screening?
BMI >30 previous macrosomic baby previous GDM 1st degree relative with DM ethnicity of high DM prevalence (South Asia, black carribean, middle eastern)
Treatment for pregnancy induced HTN?
labetalol Methyldopa for asthmatic
What week gestation for GDM screening?
booking appointment (8-10wk) and 24-8 weeks
Secondary PPh, what initial investigation will show retained placenta?
TVUS–> will show endometrial thickness >10mm
Lady has progressive weakness, subdued deep tendon reflexes and normal tone, had URTI a week ago?
Guillain-Barre syndrome
What is the management of Guillain-Barre syndrome?
IVIg or plasma exchange
35 yr-old female with eye pain and vision problems, numbness and pain on limbs, headache and coordination problems?
Multiple Sclerosis
What is the management for MS relapse?
IV methylprednisolone 3 days
What is the management for relapsing-remitting MS?
beta interferon (glatiramer, teriflunomide)
Lady has self harm, fight with boyfriend, history of child abuse. How do you treat?
DBT
Pregnant women with Mania and presenting to A&E?
Olanzapine IM Stop depression
Guy arrested carrying knives, said paert of religious beliefs. Is ‘aloof’, what is likely diagnosis?
Schizotypal
Schizotypal characteristics
●Indifference to praise and criticism ●Preference for solitary activities ●Lack of interest in sexual interactions ●Lack of desire for companionship ●Emotional coldness ●Few interests ●Few friends or confidants other than family
Schizoid characteristics
●Ideas of reference (differ from delusions in that some insight is retained) ●Odd beliefs and magical thinking ●Unusual perceptual disturbances ●Paranoid ideation and suspiciousness ●Odd, eccentric behaviour ●Lack of close friends other than family members ●Inappropriate affect ●Odd speech without being incoherent
Lady is mad depressed, feels dead inside, her organs are rotting. What do you give?
Cotard syndrome fluoxetine + olanzapine
62, increasingly withdrawn, few words used, finding it difficult to name things. Mmse 28/30. What was likely cause?
Primary progressive aphasia the language capabilities slowly and progressively become impaired. (Caused by alzheimers)
Which following features would suggest Lewy body dementia?
In LWB, get visual hallucinations, parkinsonism and fluctuating cognition. Do a DaTSCAN
Schizophrenic guy, police bring in under 136
MHA assessment and admit
COPD, on salbutamol and ipratropium. FEV1 was 40%. What do start?
LABA + ICS combination inhaler (Seretide - salmeterol + fluticasone
Man has Pancoast tumour, miosis, ptosis, clubbing, chest pain. What sign indicates extra-thoracic growth?
Thoracic outlet syndrome causes pain, in horner’s shouldn’t normally have pain. Pain characteristically is around the shoulder/scapula, but can also move to arm/hand if brachial plexus is affected.
Crohn’s - Drugs used to induce remission?
1st line: Steroids (use mesalazine if can’t use steroids) Adjunct: Azathioprine/mercaptopurine
Crohn’s - Drugs used to maintain remission?
- Azathioprine (1st line) - Methotrexate (2nd line)
UC - Drugs used to induce remission?
1st line: Aminosalycate (Mesalazine) 2nd line: Steroids (pred)
UC - Drugs used to maintain remission?
1st line: oral Aminosalicyates – Mesalazine 2nd line: Azothioprine / Mercaptopurine
Young lady with polydipsia and urea. Had DKA – which fluids do you give?
0.9% NaCl 1L – over 1st hour, 0.9% NaCl 1L – over next 2 hours, etc
DKA – once patient has been put on saline, what else do you give?
(Potassium if <3.5 then add potassium chloride to NaCl) Insulin
Man with nocturnal back pain, high ESR. Obvious myeloma – what do you do next?
1st Ix: Serum/Urine electrophoresis - to identify paraprotein / light chain urinary excretion Confirm with BM aspirate Imaging (in order of preference) - MRI, CT, skeletal survey (X-Rays)
Patient with Graves – Whats the treatment? Side effects?
Carbimazole SE: Rashes, pruiritus. Serious SE: Agranulocytosis
DM Type 1 nephropathy – patient has high hba1c and high protein in urine. What do you do?
Increase insulin
Mitral valve replacement and low arterial BP, distended neck veins, muffled heart sounds. Next step?
(Beck’s triad) Refer to CT surgeon immediately for pericardiocentesis.
Infective endocarditis antibiotics: Non prosthetic? Prosthetic? MRSA? Staph Aureus?
Non prosthetic: Amoxicillin + Gentamicin (>1wk) [<1wk is flucox and gentamicin] Prosthetic: Vancomycin, Rifampicin + Gentamicin MRSA: Vancomycin + Gentamicin
Hospital acquired pneumonia: Most common causes - Gram stain?
Pseudomonas aeruginosa primarily … gram -ve bacilli Staph aureus … gram +ve cocci also common cause of HAP
Hospital acquired pneumonia: Treatment before MC&S in mind and severe?
If mild – Doxycycline PO + Metronidazole PO If severe or can’t take oral – Benzylpenicillin IV + gentamycin IV
Patient with RUQ pain, hepatomegaly, jaundice, distension/ascites, early satiety, weight loss/cachexia, hepatic encephalopathy –which biochemical marker do you use?
HCC Alpha fetoprotein
Treatment of IgA nephropathy - Whats the other name for it?
Berger’s disease Most common GN Management: 1.Conservative if mild 2.Supportive therapy – ACE-I to control BP (<140/90) 3.If risk of high progression (persisting proteinuria + preserved renal function) – Prednisolone 4.If RPGN/AKI involved – Immunosuppression -> Prednisolone + Azathioprine
Lady with recurrent UTI and scarring. Reflux nephropathy - chronic pyelonephritis + vesico-ureteric reflux: Presentation? Investigations?
Dysuria Frequency Pyrexia Urinary incontinence at night 1.MCUG: contrast is used to see the reflux of urine during voiding 2.IVU: show scarring with thin cortex overlying a distorted calyx. Clubbing of calyx: normal cupping of calyx is reversed. 3.DMSA scan: show renal scarring due to reflux.
XRay of rheumatoid
Early x-ray findings ● loss of joint space ● juxta-articular osteoporosis ● soft-tissue swelling Late x-ray findings ● Periarticular erosions ● Subluxation
Pt with frank haematuria. He had this before and took Abx and it went away. But now it has returned. Smokes 30 ciggs a day since he was born. Bladder cancer, UTI
UTI (Be aware Penicillin can cause haematuria)
Patient with raynauds and anticentromere - Diagnosis?
Limited cutaneous systemic sclerosis Scleroderma affects face and distal limbs predominately – hardening of the connective tissue.
CREST syndrome What does it stand for?
Calcinosis, Raynaud’s phenomenon, oEsophageal dysmotility, Sclerodactyly, Telangiectasia
Scleroderma affects trunk and proximal limbs predominately Associated with scl-70 antibodies Hypertension, lung fibrosis and renal involvement seen
Diffuse cutaneous systemic sclerosis
Patient with rheumatoid + steroid use and methotrexate with swollen elbow for past 1 week. She felt hot (but didn’t tell us there was fever) - Ddx? Microscopy?
Gout, Septic arthritis (but its not cause 1 wk hx) Long needle-shaped crystals which are negatively birefringent under polarised light.
Short term management of Gout
- NSAIDs- diclofenac or indomethacin 50mg/8h for up to 8 days (strong NSAIDs) 2. Colchicine 0.5mg/6h until pain resolves. Also use if NSAIDs are contraindicated
Long term management of Gout
Long term therapy – Allopurinol. Do not start within 1 month of an attack, and NSAIDs/ Colchicine given for 4 weeks before and after starting allopurinol. 2nd line is Probenecid.
Neuro rehab: purpose of rehab
Re-learn lost functionality Reduce symptoms and improve the wellbeing of people with diseases
Patient has really high BP, low platelets and a bruise after an injection. Which of these is a relative contraindication to heparin?
Elderly Low platelets / thrombocytopenia are absolute CI to heparin, recent cerebral haemorrhage, severe hypertension; peptic ulcer; after major trauma or recent surgery to eye or nervous system; acute bacterial endocarditis
Paediatric epilepsy - protocol for status epilepticus
Time 0 mins (1st step) - Seizure starts Check ABC, high flow O2 if available Check blood glucose 5 mins (2nd step) - Midazolam 0.5 mg/kg buccally Or Lorazepam 0.1 mg/kg if intravenous access established 15 mins (3rd step) Lorazepam 0.1 mg/kg intravenously 25 mins (4th step) Phenytoin 20 mg/kg by intravenous infusion over 20 mins or (if on regular phenytoin) Phenobarbital 20 mg/kg (if known heart block or already on phenytoin)intravenously over 5 mins 45 mins (5th step) Rapid sequence induction of anaesthesia using thiopental sodium 4 mg/kg intravenously
Venous leg ulcer management
Compression bandaging (4 layer), moisturiser, oral pentoxifylline (reduces platelet aggregation and inflammation)
When do you give anti-D to non-sensitised Rh-ve mothers? When would you give ASAP?
28 and 34 weeks ● delivery of a Rh +ve infant, whether live or stillborn ● any termination of pregnancy ● miscarriage if gestation is > 12 weeks ● ectopic pregnancy (if managed surgically, if managed medically with methotrexate anti-D is not required) ● external cephalic version ● antepartum haemorrhage ● amniocentesis, chorionic villus sampling, fetal blood sampling
6 week child with congenital dysplasia -
Most unstable hips spontaneously stabilise by 3-6 weeks Pavlik harness – if child <5 months If older than – surgery
How does the COCP protect against PID?
Thickens cervical mucus – making it difficult for both sperm and bacteria to enter.
Pt with rh arthritis, on methotrexate with 6 month hx of SOB. Both fev1 and FVC reduced with ratio @ 86%. Diagnosis? Cause?
Pulmonary fibrosis Methotrexate
Patient with painful ankle and negatively birifringent crystals – what is dx?
Gout
80 year old patient with hip fracture and normal bloods (pretty much). What management (if needed) should you initiate for osteoporosis? Treatment?
Assess risk by FRAX Oral alendronate (biphosphonate) All patients starting steroids for >3 months should have an osteoporosis assessment *All patients age >65 starting steroids should be commenced on Adcal D3 + alendronate*
Patient with muscle weakness, difficulty combing hair (i.e. raising arm) with raised ESR and raised CK and Anti-Jo1 antibody, positive rheumatoid factor. Diagnosis?
Polymyositis Symmetrical, proximal muscle weakness Elevated skeletal muscle enzyme levels Symmetrical, proximal muscle weakness with insidious onset Muscles usually painles
70 year old patient with muscle aching, difficulty combing hair (i.e. raising arm) with raised ESR and normal CK and EMG normal. Diagnosis? Treatment?
Polymyalgia rheumatica Prednisolone
Patient with psoriasis – tried emollients and wants to avoid oral meds. What next?
1st line mod-severe = narrow band UVB. (Phototherapy)
Pt diagnosed with open angle glaucoma. Which piece of advice should patient be given?
Pt’s eyesight is irreversible Damage to the optic nerve is likely to be prevented or delayed. Sadly treatment cannot restore any sight that has already been lost.
Patient with sensorineural hearing loss, tinnitus, vertigo and aural fullness. Diagnosis?
Menieres
The patient gets dizzy every time he turns his head. Presents with left lateral gaze and nystagmus Diagnosis? Investigation? Treatment?
Benign paroxysmal positional vertigo Dix-halpike Epley
Patient with sensorineural unilateral hearing loss, vertigo and on MRI found to have an abnormal lesion leaving the internal auditory meatus. Diagnosis?
Acoustic neuroma aka vestibular schwannoma, arising from vestibular nerve
Pt with nose bleed which has now become bilateral with blood leakage into the mouth. Bleeding hasn’t stopped after holding onto nose. Next step?
Topical anaesthetic and cotton wool soaked in vasoconstrictor (oxymetazoline) Then cauterise with silver nitrate sticks
Pt with STEMI – Immediate management?
Morphine + metoclopramide Oxygen GTN – sublinhual/IV Aspirin 300mg Ticagrelor Anticoag – enoxaparin/abciximab
CHA2DS2-VASc score
C Congestive heart failure (or Left ventricular systolic dysfunction) - 1 H Hypertension: blood pressure consistently above 140/90 mmHg (or treated hypertension on medication) - 1 A2 Age ≥75 years - 2 D Diabetes Mellitus - 1 S2 Prior Stroke or TIA or thromboembolism - 2 V Vascular disease (e.g. peripheral artery disease, myocardial infarction, aortic plaque) - 1 A Age 65–74 years - 1 Sc Sex category (i.e. female sex) - 1
Patient with past mitral valve replacement presenting with new pan systolic murmur and fever. What is most important investigation?
Blood cultures
Patient diagnosed with angina but also has asthma. Already on aspirin – what is the first drug pt should be put on?
Verapamil
Wells criteria - What is it for?
Pulmonary embolism clinical signs and symptoms of DVT = 3 an alternative diagnosis is less likely than PE = 3 heart rate more than 100 = 1.5 immobilisation for 3 or more consecutive days or surgery in the previous 4 weeks = 1.5 previous objectively diagnosed PE or DVT = 1.5 haemoptysis = 1 malignancy (on treatment, treatment in last 6 months or palliative) = 1
Pt with TB signs – what type of stain should be done on sputum?
Ziehl Nielsen
Pt with weakness and dizziness alongside changing colour in palmar creases. What is best test? Top differential?
SynACTH. Addison’s – palmar crease pigmentation, weakness, abdo pain. Short synacthen test is best diagnostic + 1st line in diagnosing
Pt with T2 diabetes and keeps having hypos. What is the cause?
Glimeperide (Insulin/sulfonylureas (gliclazide and glimepiride)
Patient with t2 diabetes mellitus (on metformin) with high cholesterol, high BMI (31) and poor glucose control. How should the pt control their cholesterol?
Statin
Patient with 3 month history with bowel troubles and campylobacter infection prior to this. Abdo pain relieved by defacation. Altered stool passage (straining, urgency, incomplete evacuation) abdominal bloating (more common in women than men), distension, tension or hardness symptoms made worse by eating and passage of mucus Normal bloods, no fever and negative stool. What is most likely dx?
IBS
Patient with signs consistent with encephalopathy (liver failure) on the background of alcoholic cirrhosis and being alcohol independent. What is the first step in Mx?
20 degree head tilt, A-E, lactulose, treat sepsis, +/- Abx (rifaxilline), +/- Mannitol
Patient with signs consistent with encephalopathy (liver failure) on the background of alcoholic cirrhosis and being alcohol independent. What is the first step in Mx?
Lactulose Phosphate enemas Stop diuretics if low potassium
Pt with melaena, altered bowel habit and weight loss, no lesions anywhere on body. What is Dx?
Colon cancer
Pt had surgery 3 days prior and has dropped in renal output with increased creatinine. He was on amox, met and gent. What is the most immediate step in management?
Stop gent
Pt had surgery 3 days prior and has dropped in renal output with increased creatinine. He was on amox, met and gent. What is the most immediate step in management?
Stop gent
Pt with 2 weeks hx of frank haematuria and varicoceale. What is most likely Dx?
Renal cell carcinoma
Pt with PET and has HELLP. 39 weeks pregnant, what is the best step in Rx?
Delivery + IV Dexamethasone MgSO4 If hypertensive: IV Labetolol
HELLP?
Haemolysis (H), elevated liver enzymes (EL) and low platelet count (LP) . It’s a serious but rare pregnancy complication.
Pt with light bleeding and crampy pain @ 7 weeks. Has a closed OS but on USS there is something which looks like a gestational sac?
Threatened miscarriage - presents with a closed cervical OS, normal uterus size, mild / light bleeding.
Pt with light bleeding and lower abdominal pain @ 9 weeks gestation. What is definitive investigation to find out whats happening?
TV USS
Patient stage 1 and needs augmentation. What is best way?
Oxytocin
Patient stage 3 and wanted to naturally deliver placenta. What is the best way to ensure she does not loose any extra blood?
Syntometrine - is a combination of oxytocin + ergometrine. Carboprost Used in combination for delivery of placenta and prevention of PPH.
Woman with late decelerations on CTG, what next?
Do another foetal investigation - foetal blood sampling with pH. Late decelerations = deceleration starts at peak of uterine contraction, recovers after. Requires foetal blood sampling with pH. If acidotic -> Emergency c section.
Lady trying to conceive with low progesterone, oligomenorrhoea, normal fsh and LH, normal TSH. What is the cause?
Premature menopause
Pt with signs of endometriosis and a 4mm endometrioma on USS. What is the best way to manage? Investigation?
COCP TVUS
Pt with signs of endometriosis and a 4mm endometrioma on USS. What is the best way to manage? Investigation?
COCP GnRH analogues - reduce the size Laprascopic laser to reduce complications TVUS
RLQ pain sudden onset and constant pain, N+V, increased CRP, but normal WBC.
Ovaian torsion
Child born at term and starts to seize. Weight is 4.8kg, what is the first investigation that should be done?
Glucose and electrolytes
Baby (8 months) with crying episodes where baby brings legs to tummy. Mother opened nappy to find red current stool
Intersussception
Indian baby who was bought in with mum looking pale. Hb done and found to be low. Baby is 1 years old and is on cows milk. What is the reason for anaemia?
Low iron in cows milk.
New born baby and tests done. Levels of immunoreactive trypsin were found to be high. What does this point to?
Cystic fibrosis
Child with seizure going on for 20 minutes. Has been given lorazepam, what should you give him now?
Lorazepam 0.1 mg/kg intravenously Benzo
Child with seizure going on for 20 minutes. Has been given lorazepam, what should you give him now?
Lorazepam 0.1 mg/kg intravenously (Benzo)
Pt has migraine which are getting more frequent. What is the best prophylactic measure?
Propanolol - Beta Blocker.
Women presents with mixture of distal sensory and motor signs after having gastroenteritis 1 week ago. What is the worst thing you want to rule out first? Triggered by?
Guillain Barre syndrome Immune mediated demyelination often triggered by Campylobacter jejuni.
Pt with sensory and motor signs peripherally. Vitamin?
Vitamin B12 (Vitamin E)
Pt with right sided stroke with legs>arms and vision loss. What blood supply is affected?
ACA
Pt comes in with left sided weakness which lasts for 60 minutes. Treatment?
If 0-3 = Specialist assessment within 1 week of symptom onset +/- brain imaging 4 or more = Aspirin 300mg immediately, specialist assessment within 24 hours, address RFs
Pt with stroke that occurred 1 hr ago. What is the best Rx?
tpA intravenous
GCS
Eyes Spontaneous To sound To pressure None Verbal Orientated Confused Words Sounds None Motor Obey commands Localising Normal flexion Abnormal flexion Extension None
Patient with constant worries going out. Diagnosis?
Agorophobia
Patient with normal weight but having a problem binge eating. Patient uses laxatives to vomit after feeling bad. Diagnosis?
Bulimia
Patient with low TSH, normal t3 and t4, oligomenorrhoea, low FSH and LH, and exercises a lot. What is the most likely Dx?
Levothyroxine misuse
Patient with schizophrenia with high BMI and cholesterol. What medication should the pt be started on?
Amisulpiride, *Aripiprazole*, Ziprasidone - least weight gain
Pt started on clozapine and is told to come back on a weekly basis for Ix. Why?
Agranulocytosis
Patient with varicose veins with a single bleeding episode from vein. What should you do after seeing the patient in the clinic? Ix?
Refer pt to vascular team Duplex
Patient with gangrenous toe and ulcer under foot with leg pain at rest. What is the next step?
Revascularisation (critical limb ischaemia)
Patient with acute ischaemic limb. No pulses past femoral pulse and cold limp up till below knee. What is Rx?
Thrombolise from femoral down 6Ps: pain, pallor, perishingly cold, pulseless, paralysis, parasethesia
How to reduce risk of kidney stones?
● high fluid intake Reduce high purine foods such as red meat, organ meats, shell fish ● low animal protein, low salt diet ● thiazides diuretics (increase distal tubular calcium resorption)
Antibodies for SLE - Most sensitive? Most specific?
Anti-nuclear antibodies (ANA) are autoantibodies to the nuclei of your cells. dsDNA and anti-smith antibodies