XXVII - Antipsychotic & Antidepressant Drugs

Question 1

Prototype typical antipsychotic, SE: corneal/lens deposits, failure of ejaculation

Answer 1

Chlorpromazine

Question 2

Floridly psychotic patients, SE: major EPS (neuroleptic malignant syndrome)

Answer 2

Haloperidol

Question 3

DOC for suicidal and refractory schizophrenia, SE: agranulocytosis

Answer 3

Clozapine

Question 4

2nd gen. antipsychotic, SE: marked weight gain, hyperglycemia

Answer 4

Olanzapine

Question 5

2nd gen. antipsychotic, SE: priapism, hypnagogic hallucinations

Answer 5

Quetiapine

Question 6

Schizophrenia of the youth, SE: hyperprolactinemia

Answer 6

Risperidone

Question 7

Mania, SE: nephrogenic DI, teratogen (Ebstein’s anomaly)

Answer 7

Lithium

Question 8

Tricyclic antidepressant, enuresis, SE: atropine-like effects, cardiotoxicity

Answer 8

Imipramine

Question 9

Selective serotonin reuptake inhibitor (SSRI), first-line drug for major depressive disorder, SE: erectile dysfunction, serotonin syndrome

Answer 9

Fluoxetin

Question 10

Serotonin-norepinephrine reuptake inhibitor (SNRI), SE: hypertension

Answer 10

Venlafaxine

Question 11

Serotonin antagonist, SE: priapism

Answer 11

Trazodone

Question 12

Tetracyclic antidepressant, smoking cessation, SE: weight loss, priapism, seizures

Answer 12

Bupropion

Question 13

Monoamine oxidase inhibitor (MAOI), SE: hypertensive crisis when taken with tyramine (wine, cheese), serotonin syndrome

Answer 13

Phenelzine

Question 14

Signs of TCA Overdose

Answer 14

Coma, Convulsions, Cardiotoxicity

Question 15

Drugs that cause erectile dysfuntion

Answer 15

Estrogens, SSRIs, Spironolactone, Opiates, Risperidone, Ethanol, Propranolol, Finasteride, Hydrochlorothiazide

Question 16

Drugs that cause priapism

Answer 16

Alprostadil, Trazodone, Papaverine, Warfarin, Quetiapine, Sildenafil

Question 17

Malignant Hyperthermia: Onset

Answer 17

minutes

Question 18

Malignant Hyperthermia: Drugs

Answer 18

volatile anesthetics (Halothane), Succinylcholine

Question 19

Malignant Hyperthermia: Mechanism

Answer 19

massive Ca release from the SR

Question 20

Malignant Hyperthermia: Signs

Answer 20

Clonus, Hypertension, Fever, Acidosis, Rhabdomyolysis, Trismus

Question 21

Malignant Hyperthermia: First-Line Treatment

Answer 21

Dantrolene

Question 22

Serotonin Syndrome: Onset

Answer 22

hours

Question 23

Serotonin Syndrome: Drugs

Answer 23

SSRIs, MAOIs, TCAs, Meperidine, MDMA, St. John’s wort

Question 24

Serotonin Syndrome: Mechanism

Answer 24

excess serotonin

Question 25

Serotonin Syndrome: Signs

Answer 25

Fever, Agitation, Tremor, Clonus, Hyperreflexia, Diaphoresis

Question 26

Serotonin Syndrome: First-Line Treatment

Answer 26

sedation, paralysis, intubation, ventilation

Question 27

Neurologic Malignant Syndrome: Onset

Answer 27

1-3 days

Question 28

Neurologic Malignant Syndrome: Drugs

Answer 28

Antipsychotics

Question 29

Neurologic Malignant Syndrome: Mechanism

Answer 29

dopamine antagonism

Question 30

Neurologic Malignant Syndrome: Signs

Answer 30

Fever, Encephalopathy, Vitals unstable, Elevated CPK, Rigidity

Question 31

Neurologic Malignant Syndrome: First-Line Treatment

Answer 31

Diphenhydramine