XLI - Chemotherapy

Question 1

Alkylating agent, lymphoma, SE: hemorrhagic cystitis (Acrolein), Rescue: Mesna

Answer 1

Cyclophosphamide

Question 2

Alkylating agent, SE: vesicant (skin blistering)

Answer 2

Mechlorethamine

Question 3

Alkylating agent, colon CA, SE: ototoxicity, nephrotoxicity, Rescue: Amifostine

Answer 3

Cisplatin

Question 4

Alkylating agent, SE: disulfiram reaction, leukemogenesis

Answer 4

Procarbazine

Question 5

Alkylating agent, bone-marrow sparing, SE: pulmonary fibrosis

Answer 5

Bleomycin

Question 6

Alkylating agent, brain CA, SE: CNS toxicity

Answer 6

Carmustine

Question 7

Drugs that cause pulmonary fibrosis

Answer 7

Methotrexate, Bleomycin, Amiodarone, Nitrofurantoin, Busulfan, Bromocriptine

Question 8

Antimetabolite (S phase), lymphoma, GTN, SE: myelosuppression, pulmonary fibrosis, Rescue: Leucoverin (folinic acid)

Answer 8

Methotrexate

Question 9

Antimetabolite (S phase), acute leukemia, SE: myelosuppression, hepatotoxicity, metabolism inhibited by allopurinol

Answer 9

6-Mercaptopurine

Question 10

Antimetabolite (S phase), colorectal and skin CA, thymine-less death of cells, SE: myelosuppression

Answer 10

5-Fluorouracil

Question 11

Antimetabolite (most specific for S phase), CML in blast crisis

Answer 11

Cytarabine

Question 12

Antimetabolite (S phase), inhibits ribonucleotide reductase, pancreatic CA

Answer 12

Gemcitabine

Question 13

Vinca alkaloid, prevents microtubule assembly, SE: peripheral neuropathy

Answer 13

Vincristine

Question 14

Podophyllotoxin, inhibits DNA topoisomerase II, lung CA, non-Hodgkin’s lymphoma, GTN

Answer 14

Etoposide

Question 15

Camptothecin, inhibits DNA topoisomerase I, small cell lung CA

Answer 15

Topotecan

Question 16

Taxane, prevents microtubule disassembly, advanced breast and ovarian CA

Answer 16

Paclitaxel

Question 17

Intercalating agent, SE: dilated cardiomyopathy, Rescue: Dexrazoxane

Answer 17

Doxorubicin

Question 18

Testicular CA, most specific for G2 phase, SE: pulmonary fibrosis

Answer 18

Bleomycin

Question 19

Melanoma, Wilm’s tumor, GTN

Answer 19

Actinomycin D

Question 20

Tyrosine kinase inhibitor, CML, SE: fluid retention, multiple drug interactions

Answer 20

Imatinib

Question 21

Metastatic breast CA, HER2-neu

Answer 21

Trastuzumab

Question 22

Inhibits VEGF, metastatic cancers

Answer 22

Bevacizumab

Question 23

Differentiation therapy, acute promyelocytic leukemia, only vitamin that can cure cancer

Answer 23

All-Trans Retinoic Acid (Vitamin A)