XVIII - Antivirals

Question 1

Guanosine analogue, treatment of HSV and VZV, requires activation by viral thymidine kinase, SE: crystalluria

Answer 1

Acyclovir

Question 2

Treatment of CMV, requires activation by viral thymidine kinase

Answer 2

Gancyclovir

Question 3

Pyrophosphate analogue, treatment of HSV, VZV and CMV, does not require activation by viral thymidine kinase

Answer 3

Foscarnet

Question 4

Prevents viral uncoating, Influenza A, Rubella, SE: cerebellar dysfunction, livedo reticularis

Answer 4

Amantadine

Question 5

Neuraminidase inhibitor, DOC for Influenza

Answer 5

Oseltamivir

Question 6

Treatment for Hepatitis B

Answer 6

Lamivudine

Question 7

Treatment for Hepatitis C and RSV

Answer 7

Ribavirin

Question 8

Nucleoside reverse transcriptase inhibitor (NRTI), requires phosphorylation, primary drug for HIV, prevents vertical transmission of HIV, SE: lactic acidosis

Answer 8

Zidovudine (AZT)

Question 9

Non-nucleoside reverse transcriptase inhibitor (NNRTI), no phosphorylation required, SE: hepatotoxic

Answer 9

Delavirdine

Question 10

Protease inhibitor, SE: fat redistribution syndrome, hyperlipidemia, insulin resistance

Answer 10

Indinavir

Question 11

Fusion inhibitor, binds gp41 subunit

Answer 11

Enfuvirtide

Question 12

Binding inhibitor, CCR5 antagonist

Answer 12

Maraviroc

Question 13

Non-Nucleoside Reverse Transcriptase Inhibitors

Answer 13

Nevirapine, Efavirenz, Delavirdine