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Pathology Flashcards > XII - The Hematopoietic and Lymphoid Systems > Flashcards

XII - The Hematopoietic and Lymphoid Systems Flashcards

1
Q

Pathology Flashcards

Average volume per cell, expressed in femtoliters.

A

Mean cell volume (MCV)(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 423

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2
Q

Pathology Flashcards

A reduction in the oxygen-transporting capacity of blood.

A

Anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 422

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3
Q

Pathology Flashcards

The average content of hemoglobin per red cell, expressed in picograms.

A

Mean cell hemoglobin (MCH)(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 423

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4
Q

Pathology Flashcards

The average concentration of hemoglobin in a given volume of packed red cells, expressed in g/dL.

A

Mean cell hemoglobin concentration (MCHC)(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 423

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5
Q

Pathology Flashcards

The coefficient of variation of red cell volume.

A

Red cell distribution width (RDW)(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 423

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6
Q

Pathology Flashcards

Anemia of acute blood loss is described as ______.

A

Normocytic, normochromic anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 423

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7
Q

Pathology Flashcards

Life span of a normal red cell.

A

120 days(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 424

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8
Q

Pathology Flashcards

Anemia characterized by an increased rate of cell destruction, a compensatory increase in erythropoeisis that results in reticulocytosis, and retention of products of cell destruction, including iron.

A

Hemolytic anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 424

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9
Q

Pathology Flashcards

A circulating protein that binds and clears free hemoglobin.

A

Haptoglobin(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 424

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10
Q

Pathology Flashcards

Hemolysis that can result from mechanical trauma, or biochemical or physical agents that damage the red cell membrane.

A

Intravascular hemolysis(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 424

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11
Q

Pathology Flashcards

Hemolysis which takes place largely within phagocytic cells of the spleen and liver.

A

Extravascular hemolysis(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 424

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12
Q

Pathology Flashcards

This disorder is characterized by an intrinsic defect in the red cell membrane, that renders the cells spheroidal, less defomable and vulnerable to splenic sequestration and destruction.

A

Hereditary spherocytosis(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 424

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13
Q

Pathology Flashcards

Small, dark nuclear remnants seen within red cells in PBS of hereditary spherocytosis.

A

Howell-Jolly bodies(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 425

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14
Q

Pathology Flashcards

On PBS, red cells are spherical which lack central pallor, and they show increased osmotic fragility when placed in hypotonic salt solutions.

A

Hereditary spherocytosis(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 425

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15
Q

Pathology Flashcards

Structural proteins that are defective in hereditary spherocytosis.

A

Spectrin and ankyrin(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 425

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16
Q

Pathology Flashcards

This results from substitution of valine for glutamic acid at the 6th position of the B-chain, producing HbS.

A

Sickle cell anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 426

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17
Q

Pathology Flashcards

Bizarre, elongated, spindled or boat-shaped cells on PBS.

A

Sickel cell anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 427

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18
Q

Pathology Flashcards

Prominent cheekbones and changes in skull resembling a “crew-cut” skull x-ray.

A

Sickle cell anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 427

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19
Q

Pathology Flashcards

Patients with sickle cell disease are predisposed to infections caused by these type of bacteria.

A

Encapsulated bacteria(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 428

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20
Q

Pathology Flashcards

Treatment for sickle cell disease by increasing levels of HbF.

A

Hydroxyurea(TOPNOTCH)

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21
Q

Pathology Flashcards

Treatment for sickle cell disease by increasing levels of HbF.

A

Hydroxyurea(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 428

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22
Q

Pathology Flashcards

Feared complication of sickle cell disease which can be trigerred by pulmonary infections or fat emboli from necrotic marrow that secondarily involve the lung.

A

Acute chest syndrome(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 428

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23
Q

Pathology Flashcards

Major complication of sickle cell disease which occurs in the setting of acute chest syndrome, causing ischemic injury to the CNS.

A

CNS stroke(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 428

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24
Q

Pathology Flashcards

Represents a sudden but usually temporary cessation of erythropoeisis, usually trigerred by parvovirus B19 infections in patients with sickle cell disease.

A

Aplastic crises(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 428

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25
Q

Pathology Flashcards

In beta thalassemia, an individual who inherits one abnormal allele (out of 2) has this asymptomatic to mildly symptomatic condition.

A

B- Thalassemia minor/trait(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 429

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26
Q

Pathology Flashcards

Individuals with B-thalassemia who inherit two abnormal alleles, with severe anemia requiring regular blood tranfusions.

A

B- Thalassemia major(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 429

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27
Q

Pathology Flashcards

Red cells with a central, dark-red puddle due to collection of hemoglobin.

A

Target cells(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 430

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28
Q

Pathology Flashcards

Target cells are often seen in this condition.

A

B-thalassemia minor(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 430

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29
Q

Pathology Flashcards

In the PBS of this condition, nucleated red cells (normoblasts) are seen, which reflect underlying erythropoeisis.

A

B-thalassemia major(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 430

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30
Q

Pathology Flashcards

Anemia of beta thalassemia.

A

Microcytic, hypochromic(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 430

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31
Q

Pathology Flashcards

Disease caused by deletion of 3 alpha globin genes.

A

Hemoglobin H disease(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 431

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32
Q

Pathology Flashcards

Condition caused by deletion of 1 alpha globin gene.

A

Silent carrier(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 431

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33
Q

Pathology Flashcards

Condition caused by deletion of 2 alpha globin genes.

A

Alpha thalassemia trait(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 431

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34
Q

Pathology Flashcards

Condition caused by deletion of all four alpha globin genes.

A

Hydrops fetalis(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 429

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35
Q

Pathology Flashcards

Precipitates of denatured globin seen in RBC’s.

A

Heinz bodies(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 432

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36
Q

Pathology Flashcards

Heinz bodies are seen in the blood smear of this condition.

A

G6PD Deficiency(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 432

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37
Q

Pathology Flashcards

Bite cells are seen in ________.

A

G6PD Deficiency(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 432

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38
Q

Pathology Flashcards

A rare disorder of unknown etiology, causes hemolytic anemia which results from an acquired membrane defect secondary to a mutation that affects myeloid stem cells. Hemolysis occurs during sleep.

A

Paroxysmal nocturnal hemoglobinuria(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 432

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39
Q

Pathology Flashcards

Hemolysis caused by IgG or IgA antiodies that are active at 37 degC, which results in opsonization of red cells by the autoantibodies.

A

Warm antibody immunohemolytic anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 433

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40
Q

Pathology Flashcards

Anemia caused by low-affinity IgM which bind to red cell membranes only at temp <30degC, commonly experienced by distal parts of the body.

A

Cold antibody immunohemolytic anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 433

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41
Q

Pathology Flashcards

Anemia observed in a variety of pathologic states, in which small vessels become particularly obstructed.(e.g. DIC, malignant HTN, SLE, etc.)

A

Microangiopathic hemolytic anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 433

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42
Q

Pathology Flashcards

Schistiocytes, burr cells, helmet cells, triangle cells are seen in this condition.

A

Microangiopathic hemolytic anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 433

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43
Q

Pathology Flashcards

X-linked disorder in which red cells are unusually susceptible to damage cause by oxidants.

A

G6PD Deficiency(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 432

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44
Q

Pathology Flashcards

Red blood cells in iron deficiency anemia.

A

Microcytic, hypochromic(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 436

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45
Q

Pathology Flashcards

Diagnostic criteria for iron deficiency anemia:____ Ferritin____Serum iron level____Transferrin saturation____Total Iron Binding Capacity (TIBC)

A

Low ferritinLow serum iron levelsLow transferrin saturationIncreased TIBC(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 435

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46
Q

Pathology Flashcards

Diagnostic criteria for anemia of chronic disease:____ Ferritin____Serum iron level____Transferrin saturation____Total Iron Binding Capacity (TIBC)

A

Increased ferritinLow serum iron levelsLow transferrin saturationDecreased TIBCNormocytic, normochromic anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 435

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47
Q

Pathology Flashcards

Principal causes of megaloblastic anemia.

A

Folate deficiencyVitamin B12 deficiency(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 437

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48
Q

Pathology Flashcards

Bone marrow is markedly hypercellular as a sult of increased number of megaloblasts, which are large cells that have delicate, finely reticulated nuclear chromatin and abundant basophilic cytoplasm.

A

Megaloblastic anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 437

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49
Q

Pathology Flashcards

PBS finding in neutrophils and red cells of patients with megaloblastic anemia.

A

Hypersegmented neutrophils, large, egg-shaped macro-ovalocytes(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 437

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50
Q

Pathology Flashcards

Difference between megloblastic and pernicious anemia.

A

Presence of neurologic abnormalities in pernicious anemia.(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 438

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51
Q

Pathology Flashcards

Deficiency in folate causes this type of anemia.

A

Megaloblastic anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 438

52
Q

Pathology Flashcards

Deficiency in Vitamin B12 causes this type of anemia.

A

Pernicious anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 438

53
Q

Pathology Flashcards

Etiology of pernicious anemia.

A

1.Vitamin B12 malabsorption secondary to autoantibodies against parietal cells and intrinsic factor which is needed in its absorption.2. Gastrectomy or ileal resection(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 438

54
Q

Pathology Flashcards

Principal neurologic lesion in pernicious anemia.

A

Demyelination of posterior and lateral columns of the spinal cord.(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 439

55
Q

Pathology Flashcards

Bone marrow is markedly hypocellular, with >90% of the intertrabecular space being occupied by fat.

A

Aplastic anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 439

56
Q

Pathology Flashcards

Tear drop cells are also called __________.

A

Dacrocytes(TOPNOTCH)

57
Q

Pathology Flashcards

Tear drop cells are also called __________.

A

Dacrocytes(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 440

58
Q

Pathology Flashcards

Dacrocytes are found in peripheral blood of patients with this type of anemia.

A

Myelophthisic anemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 440

59
Q

Pathology Flashcards

Increase in blood concentration of red cells, with an increase in Hgb concentration.

A

Polycythemia or erythrocytosis(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 441

60
Q

Pathology Flashcards

Polycythemia secondary to reduced plasma volume.

A

Relative polycythemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 441

61
Q

Pathology Flashcards

Polycythemia secondary to abnormal proliferation of myeloid stem cells and low erythropoeitin levels.

A

Primary polycythemia (Absolute)(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 441

62
Q

Pathology Flashcards

Polycythemia secondary to increased erythropoeitin levels due to lung disease, high-altitude living, cyanotic heart disease and EPO secreting tumors.

A

Secondary polycythemia (Absolute)(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 441

63
Q

Pathology Flashcards

Total white cell count is reduced to 1000 cells/uL. Affected persons are extremely susceptible to bacterial and fungal infections.

A

Neutropenia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 441

64
Q

Pathology Flashcards

A self-limited disease of adolescents and young adults that is causd by B lymphocytotropic EBV characterized by fever, sore throat and generalized lymphadenitis, an increase of atypical lymphocytes in blood and an antibody and T cell response to EBV.

A

Infectious mononucleosis(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 442

65
Q

Pathology Flashcards

Cells with abundant cytoplasm 12-16um in diameter that contains azurophilic granules, and an oval, indented or folded nucleus.

A

Atypical lymphocytes (Infectious mononucleosis)(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 442

66
Q

Pathology Flashcards

Inflamed nodes are swollen, gray-red and engorged. There are large germinal centers containing numerous mitotic figures. Affected nodes are tender and fluctuant if with extensive abscess formation.

A

Acute nonspecific lymphadenitis(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 444

67
Q

Pathology Flashcards

This pattern is associated with infections or inflammatory processes that activate B cells which create a follicular or germinal center reaction. Lymph node architecture is preserved, lymphoid nodules vary in shape and size, mixed lymphocytic infiltrates with prominent phagocytic and mitotic activity within germinal centers.

A

Follicular hyperplasia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 444

68
Q

Pathology Flashcards

Reactive pattern characterized by distention and prominence of the lymphatic sinusoids, due to marked hypertrophy of lining endothelial cells and an infiltrate of histiocytes. Encountered in lymph nodes draining cancers.

A

Sinus histiocytosis(TOPNOTCH)

69
Q

Pathology Flashcards

Characterized by reactive changes within T-cell regions of the lymph node, usually encountered during viral infections, following certain vaccinations, and immune reactions induced by certain drugs.

A

Paracortical hyperplasia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 444

70
Q

Pathology Flashcards

Formation of sarcoid-like ganulomas that undergo central necrosis associated with neutrophil accumulation. This irregular stellate necrotizing granuloma is seen in patients presenting with a raised inflammatory node, vesicle or eschar at site of injury. History of exposure to cats.

A

Cat scratch disease(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 444

71
Q

Pathology Flashcards

Causative agent for cat scratch disease(TOPNOTCH)

A

Bartonella henselae(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 444

72
Q

Pathology Flashcards

Lymphoblasts with irregular nuclear contours, condensed chromatin , small nucleoli and scant agranular cytoplasm. Blasts compose >25% of marrow cellularity. Most common childhood leukemia.

A

Acute lymphocytic leukemia (ALL)(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 447

73
Q

Pathology Flashcards

Frequent small “cleaved” cells mixed with large cells, growth pattern nodular, centroblasts present. Occurs in older adults, usually involves nodes, marrow, spleen. Associated with t(14;18).

A

Follicular lymphoma(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 451

74
Q

Pathology Flashcards

Small to intermediate-sized irregular lymphocytes growing in a diffuse pattern, no centroblasts and proliferation centers. Occurs mainly in older males, GI tract commonly affected. Associated with t(11;14).

A

Mantle cell lymphoma(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 452

75
Q

Pathology Flashcards

Plasma cells in sheets, with prominent nucleoli or inclusion containing Ig. Presents as disseminated bone disease, with destructive lytic lesions.

A

Plasmacytoma / plasma cell myeloma(TOPNOTCH)

76
Q

Pathology Flashcards

Intermediate-sized round lymphoid cells with 2-5 prominent nucleoli. Nuclear remnants phagocytosed by interspersed macrophages with abundant clear cytoplasm, “starry sky pattern”

A

Burkitt lymphoma(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 453

77
Q

Pathology Flashcards

Sheets of small, round lymphocytes and scattered ill-defined foci of larger, actively dividing cells diffusely efface involved LN. A foci of mitotically active cells called proliferation centers are pathognomonic.

A

Small lymphocytic leukemia (SLL) / Chronic lymphocytic leukemia (CLL)(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 450

78
Q

Pathology Flashcards

Fragile neoplastic lymphocytes that are frequently disrupted during smear preparation.

A

Smudge cells(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 450

79
Q

Pathology Flashcards

Smudge cells are seen in this type of leukemia.

A

CLL(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 450

80
Q

Pathology Flashcards

Tumor cells have large nuclei with open chromatin and prominent nucleoli. Most important type of lymphoma in adults, accounting to ~50% of adult NHL.

A

Diffuse large B-cell lymphoma(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 452

81
Q

Pathology Flashcards

Multifocal destructive bone lesions seen as punched-out defects in bone radiographs.

A

Multiple myeloma(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 455

82
Q

Pathology Flashcards

Excess lightvor heavy chains along with complete Igs synthesized by neoplastic plasma cells.

A

Bence-Jones proteins(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 454

83
Q

Pathology Flashcards

Cells with two mirror-image nuclei or nuclear lobes, each containing a large acidophilic nucleolus surrounded by a distinctive clear zone, imparting a n owl-like appearance.

A

Reed-Sternberg cell(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 456

84
Q

Pathology Flashcards

A distinctive groups of neoplasms that arise almost invariably in a single lymph node or chain of lymph nodes and spread characteristically in a stepwise fashion to anatomically contiguous nodes.

A

Hodgkin Lymphoma(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 456

85
Q

Pathology Flashcards

Most common form of Hodgkin lymphoma, characterized by a large cell which has a single multilobate nucleus with small nucleoli and an abundant pale-staining cytoplasm called lacunar cells.

A

Nodular sclerosis HL(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 457

86
Q

Pathology Flashcards

Most common form of HL in patients greater than 50 years old, with male predominance, plentiful RS cells and heterogenous cellular infiltrates.

A

Mixed cellularity HL(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 458

87
Q

Pathology Flashcards

Cells found in adult T-cell lymphoma which appear to have multilobulated nuclei.

A

Cloverleaf or flower cell(TOPNOTCH)

88
Q

Pathology Flashcards

Subgroup of HL characterized by a large number of small resting lymphocytes admixed with a variable number of benign histiocytes. Variant RS cells described as multilobed, puffy nucleus Which appears like a “popcorn”. Excellent prognosis.

A

Lymphocyte-predominance HL(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 458

89
Q

Pathology Flashcards

Cells with fiery red cytoplasm.

A

Flame cells(TOPNOTCH)

90
Q

Pathology Flashcards

Cells with pink globular cytoplasmic inclusions.

A

Russell bodies(TOPNOTCH)

91
Q

Pathology Flashcards

Cells with blue globular nuclear inclusions.

A

Dutcher bodies(TOPNOTCH)

92
Q

Pathology Flashcards

Multiple nuclei, prominent nucleoli, and cytoplasmic droplets containing Ig.

A

Bizarre, multinucleated cells(TOPNOTCH)

93
Q

Pathology Flashcards

Bizarre multinucleated cells, flame cells, Russel bodies and Dutcher bodies are all seen in what disease?

A

Multiple myeloma(TOPNOTCH)

94
Q

Pathology Flashcards

Bone marrow aspirate shows hypercellular martow packed with myeloblasts and azurophilic needle-like material called Auer rods.

A

Acute Myelogenous Leukemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 462

95
Q

Pathology Flashcards

Leukemia of children most responsive to chemotherapy.

A

Acute Lymphoblastic Leukemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 461

96
Q

Pathology Flashcards

Mature B-cell tumor in the elderly, where cells have fine hair-like projections (hairy cells).

A

Hairy cell leukemia(TOPNOTCH)

97
Q

Pathology Flashcards

Hodgkin lymphoma subgroup most commonly associated with EBV infection.

A

Lymphocyte depleted(TOPNOTCH)

98
Q

Pathology Flashcards

Mature B-cell tumor in the elderly, where cells have fine hair-like projections (hairy cells).

A

Hairy cell leukemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 459

99
Q

Pathology Flashcards

t(9;22) is also called ______.

A

Philadelphia chromosome(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 465

100
Q

Pathology Flashcards

Hodgkin lymphoma subgroup with highest count of RS cells.

A

Mixed cellularity type(TOPNOTCH)

101
Q

Pathology Flashcards

This correlates with good prognosis in Hodgkin lymphoma.

A

High Lymphocyte : Reed-Sternberg cell ratio(TOPNOTCH)

102
Q

Pathology Flashcards

Hodgin lymphoma subgroup not associated with EBV.

A

Nodular sclerosis and lymphocyte predominant(TOPNOTCH)

103
Q

Pathology Flashcards

Hodgkin lymphoma subgroup with poorest prognosis.

A

Lymphocyte depleted HL(TOPNOTCH)

104
Q

Pathology Flashcards

Tumor of the thymus associated with myastheni gravis and pure red cell aplasia.

A

Thymoma(TOPNOTCH)

105
Q

Pathology Flashcards

Pentalaminar tubules, often with a dilated terminal end (tennis racket-like appearance).

A

Birbeck granules(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 467

106
Q

Pathology Flashcards

Proliferative disorder of the dendritic cells which has birbeck granules.

A

Langerhans Cell Histiocytosis(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 467

107
Q

Pathology Flashcards

Pathology behind polycythemia vera.

A

Mutation in tyrosine kinase JAK2, which acts in signalling pathways of the erythropoeitin receptors, rendering them hypersensitive to erythropoeitin.(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 466

108
Q

Pathology Flashcards

Treatment for polycythemia vera.

A

Phlebotomy(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 466

109
Q

Pathology Flashcards

Collection of aggressive tumors that are comprised of immature myeloblasts which replace the marrow and suppress normal hematopoiesis.

A

Acute Myelogenous Leukemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 467

110
Q

Pathology Flashcards

Myeloid tumor arising from a pluripotent stem cell associated with mutatios of the BCR-ABL gene. If untreated, may progress to a blast crisis.

A

Chronic Myelogenous Leukemia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 467

111
Q

Pathology Flashcards

Most common myelodysplastic syndrome. A myeloid tumor in which abnormal megakaryocytes stimulate marrow fibroblasts to release collagen, replacing the marrow space, leading to pancytopenia and extramedullary hematopoeisis.

A

Myeloid metaplasia with Myelofibrosis(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 467

112
Q

Pathology Flashcards

Other name for acute disseminated Langerhans cell histiocytosis.

A

Letterer-Siwe disease(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 468

113
Q

Pathology Flashcards

Caused by a systemic activation of coagulation pathways, leading to formation of thrombi throughout the microcirculation.

A

Disseminated intravascular coagulation(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 469

114
Q

Pathology Flashcards

Characterized by spontaneous bleeding, prolonged bleeding time, and normal PT and PTT.

A

Thrombocytopenia(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 471

115
Q

Pathology Flashcards

Drug-induced disorder caused by IgG antibodies that bind to platelet factor IV on platelet surfaces, which activates platelets and induce their aggregation.

A

Heparin-Induced Thrombocytopenia (HIT)(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 472

116
Q

Pathology Flashcards

Associated with pentad of fever, thrombocytopenia, microangipathic hemolytic anemia, transient neurologic deficits and renal failure.

A

Thrombotic thrombocytic purpura(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 472

117
Q

Pathology Flashcards

Associated with childhood onset microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. No neurologic symptoms.

A

Hemolytic uremic syndrome(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 472

118
Q

Pathology Flashcards

Caused by antiplatelet antibodies directed against glycoproteins IIb-IIIa, Ib-IX.

A

Immune thrombocytopenic purpura(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 472

119
Q

Pathology Flashcards

Decreased gp Ib leads to defective platelet adhesion, associated with decreased platelet count.

A

Bernard-Soulier Syndrome(TOPNOTCH)

120
Q

Pathology Flashcards

Caused by deficiency of ADAMTS13, a vWF metalloprotease.

A

Thrombotic thrombocytopenic purpura(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 472

121
Q

Pathology Flashcards

Caused by shiga-like toxin in EHEC (E. coli O157:H7) from improperly cooked burgers.

A

Hemolytic uremic syndrome(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 472

122
Q

Pathology Flashcards

Decreased gp IIb-IIIa leads to defective platelet aggregation, associated with normal platelet count.

A

Glanzmann thrombasthenia(TOPNOTCH)

123
Q

Pathology Flashcards

Most common bleeding disorder.

A

vWF disease(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 474

124
Q

Pathology Flashcards

Most common hereditary disease associated with life threatening bleeding,

A

Hemophilia A(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 474

125
Q

Pathology Flashcards

An X-linked recessive disorder caused by reduction in factor VII activity.

A

Classic Hemophilia/ Hemophilia A(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 474

126
Q

Pathology Flashcards

An X-linked disorder caused by deficiency of Factor IX, or Christmas factor. Bleeding time is normal, PTT is prolonged.

A

Hemophilia B/ Christmas Disease(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 474

127
Q

Pathology Flashcards

A state associated with excessive removal of formed elements of blood, resulting in anemia, leukopenia or thrombocytopenia.

A

Hypersplenism(TOPNOTCH)Robbins Basic Pathology, 8th Ed. p. 476

Pathology Flashcards (23 decks)

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