Xenobiotics Flashcards by joseph dizon

Q

Attachment of new functional group

A

Biotransformation

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Q

Site of xenobiotic metabolism

A

Liver

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Q

Masking of existing

A

Conjugation

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Q

Monooxigenase, catalyze hydroxilation

A

Cytochrome 450

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Q

Most frequent conjugation reaction

A

Glucuronidation

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Q

Catalyst of glucuronidase

A

UDP glucoronic acid

Glucuronosyltransferase

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Q

Active sulfate

A

Adenosine 3 phosphate 5 phosphosulfate PAPS

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Q

Enzyme catalyzing GSH

A

Glutathione S transferase

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Q

Glutamic acid
Cysteine
Glyceine

A

GSH tripeptide

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Q

Catlyzes acetylation

A

Acetyltransferase

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Q

Broad spectrum

A

CYP 3A4 enzyme

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Q

Fastacetylation

A

Asian

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Q

Slow aectylation

A

Caucasian

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Q

Methylation

A

L metionine adenosyltransferase

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Q

Involve in mechanism of xeno

A

NADPH

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Q

Lipid involve in mech

A

Phosphatidylcholine

Q

Mitochondria . Er

A

Answer

Q

Arabic number

A

Family

Q

Capital letter

A

Sub family

Q

Main goal

A

Make it hydrophilic for urine excretion

Q

Usually breakdown due to acetylation

A

Isoniazid