Xenobiotics Flashcards
0
Q
Attachment of new functional group
A
Biotransformation
1
Q
Site of xenobiotic metabolism
A
Liver
2
Q
Masking of existing
A
Conjugation
3
Q
Monooxigenase, catalyze hydroxilation
A
Cytochrome 450
4
Q
Most frequent conjugation reaction
A
Glucuronidation
5
Q
Catalyst of glucuronidase
A
UDP glucoronic acid
Glucuronosyltransferase
6
Q
Active sulfate
A
Adenosine 3 phosphate 5 phosphosulfate PAPS
7
Q
Enzyme catalyzing GSH
A
Glutathione S transferase
8
Q
Glutamic acid
Cysteine
Glyceine
A
GSH tripeptide
9
Q
Catlyzes acetylation
A
Acetyltransferase
10
Q
Broad spectrum
A
CYP 3A4 enzyme
11
Q
Fastacetylation
A
Asian
12
Q
Slow aectylation
A
Caucasian
13
Q
Methylation
A
L metionine adenosyltransferase
14
Q
Involve in mechanism of xeno
A
NADPH
