Wounds Flashcards

1
Q

Mechanical debridement of wounds consist of

A

Wet-to-dry, wet-to-wet dressing, manual debridement with gauze or irrigation

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2
Q

Best choice of suture for closure of contaminated wounds

A

Totally not sure about this one. A monofilament absorbable suture - Monocryl? But PDS if under a lot of tension

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3
Q

Most important factor in management of contaminated/Infected wounds

A

Removal of devitalised tissue

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4
Q

Granulation tissue consist of

A

Collagen (type III), capillaries, fibroblasts

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5
Q

Describe the phases of wound repair

A

Inflammatory: Haemostasis and inflammation Tissue Formation: Angiogenesis, Fibroplasia, Tissue Formation, Epithelialisation, Contaction Remodelling/Maturation: Replacement of hyaluronan in provisional cellular matrix with proteoglycans in extracellular matrix Alignment of collagen fibres Gain in strength of wound

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6
Q

2 main cell types in wound healing inflammatory phase

A

Platelets and neutrophils

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7
Q

Differences between low and high pressure lavage in wound irrigation

A

Low pressure lavage is ideal; 10-15psi. Can used 35ml syringe with 19 gauge needle, holes punched in the top of a saline bottle. Encourages debris and bacteria to wash away from the wound High usually uses a single water jet. pressure lavage is bad: eg. WaterPik. Causes more tissue trauma and may force debris/bacteria further into tissues. However, this can be utilised in circumstances, such as abdominal lavage

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8
Q

What are the 3 purposes of drains

A

Facilitate elimination of dead space Evacuate existing fluid and gas accumulation Prevent anticipated formation of fluid collections

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9
Q

What are the advantages and disadvantages of penrose drains?

A

Advantages: Economical Can be used in lots of situations Disadvantages May kink Not useful in body cavities Passive only, no suction possible

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10
Q

What are the advantages and disadvantages of Jackson-Pratt drain

A

Advantages: Closed or open system Excellent for body cavities Less reactive Disadvantages: Attaching container can be difficult depending on location

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11
Q

What locations should be used to drain a) fluid and b) air from the thorax?

A

a) Ventral (2 inches above elbow) 7th intercostal space (front of rib) b) Dorsal 12th intercostal space (front of rib)

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12
Q

What complications can occur with drains

A

Foreign body response Ascending infections Portion of drain left in wound Loss of function/blockage Linkage of drain Suture dehiscence Damage to vessels and nerves

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13
Q

Which dressings can be used for heavily infected wounds?

A

Hypertonic saline dressing Honey Antimicrobial dressing Should use surgical debridement first

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14
Q

What are the advantages of calcium alginate dressings?

A

Calcium in dressing interacts with sodium in wound, providing wound exudate, stimulating fibroblasts and epithelial cells and speeds wound homeostasis Calcium modulates epithelial cell proliferation and migration Conform, vertical wicking, good for moderately to heavily exudative wounds Can moisten if insufficient exudate Change 3-7 days so fewer chances for contamination and reduced cost

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15
Q

Define bacterial contamination, colonisation and infection

A

Contamination: Bacteria without multiplication or trauma to host Colonisation: Attached to tissue and multiplying but not causing trauma to host Infection: Bacteria invade healthy tissue and multiply, overwhelming host’s response

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16
Q

What are the four classes of wound?

A

Clean: Surgical and do not involve resp, GI or urogenital Clean contaminated: Surgical with lumen of resp, GI or urogenital Contaminated: Traumatic, gross contamination, necrotic debris Infected: Large numbers of bacteria, inflammation, edema, suppuration

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17
Q

What is a keloid?

A

Similar to hypertrophic scar but extends beyond original wound margin and rarely regresses. May be due to increased number of epidermal Langerhans’ cells. Treatment: Steroid injection, surgical excision, radiation therapy, compression and tension reduction used

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18
Q

Name 3 tension relieving suture patterns

A

Horizontal Mattress Far-near-near-far Walking suture

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19
Q

Describe a V-Y Plasty

A

V-shaped incision with the point of the V directed away from the defect to be closed Close the original defect Close V incision by converting it to a Y Longer legs of the V make a greater degree of tension relief Use for eyelid scar revision and closing elliptical defects

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20
Q

What is a method of closing a circular skin defect

A

a.Suture along relaxing skin lines of tension then remove dog ears b. Convert to X or Y c. Excise 2 triangles on opposite sides, creating a fusiform defect; height of triangle should be equal to dimeter of the circle; removes skin of 1.5x original defect d. Double S-shaped incision with bi-winged excision e. Bow tie f. Combined V incision

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21
Q

Describe a bipedicle flap

A

Single longitudinal incision parallel to defect, or one incision on each side Skin flaps approximately same width as original defect Two sources of blood supply remain Burrow’s triangles can be used to help with excess laxity/dog ears Original defect is closed New incision(s) are left open

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22
Q

What is the difference between a rotation flap and a transposition flap

A

Rotation flap: Create semicircular incision and move tissue laterally to cover defect Transposition flap: Rectangular, single pedicle flap created adjacent to defect and rotated on it’s pedicle. Can be rotated up to 180 degrees but rotation shortens flap

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23
Q

What are the 3 purposes of drains

A

Facilitate elimination of dead space Evacuate existing fluid and gas accumulation Prevent anticipated formation of fluid collections

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24
Q

What are the advantages and disadvantages of penrose drains?

A

Advantages: Economical Can be used in lots of situations Disadvantages May kink Not useful in body cavities Passive only, no suction possible

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25
Q

What are the advantages and disadvantages of Jackson-Pratt drains

A

Advantages: Closed or open system Excellent for body cavities Less reactive Disadvantages: Attaching container can be difficult depending on location

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26
Q

What locations should be used to drain a) fluid and b) air from the thorax

A

a) Ventral (2 inches above elbow) 7th intercostal space (front of rib) b) Dorsal 12th intercostal space (front of rib)

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27
Q

What complications can occur with drains

A

Foreign body response Ascending infections Portion of drain left in wound Loss of function/blockage Linkage of drain Suture dehiscence Damage to vessels and nerves

28
Q

Which dressings can be used for heavily infected wounds

A

Hypertonic saline dressing

Honey

Antimicrobial dressing

Should use surgical debridement first

29
Q

What are the advantages of calcium alginate dressings

A

Calcium in dressing interacts with sodium in wound, providing wound exudate, stimulating fibroblasts and epithelial cells and speeds wound homeostasis

Calcium modulates epithelial cell proliferation and migration

Conform, vertical wicking, good for moderately to heavily exudative wounds

Can moisten if insufficient exudate

Change 3-7 days so fewer chances for contamination and reduced cost

30
Q

Define bacterial contamination, colonisation and infection

A

Contamination: Bacteria without multiplication or trauma to host

Colonisation: Attached to tissue and multiplying but not causing trauma to host

Infection: Bacteria invade healthy tissue and multiply, overwhelming host’s response

31
Q

What are the four classes of wound

A

Clean: Surgical and do not involve resp, GI or urogenital

Clean contaminated: Surgical with lumen of resp, GI or urogenital

Contaminated: Traumatic, gross contamination, necrotic debris

Infected: Large numbers of bacteria, inflammation, edema, suppuration

32
Q

What is a keloid

A

Similar to hypertrophic scar but extends beyond original wound margin and rarely regresses. May be due to increased number of epidermal Langerhans’ cells.

Treatment: Steroid injection, surgical excision, radiation therapy, compression and tension reduction used

33
Q

Name 3 tension relieving suture patterns

A

Horizontal Mattress

Far-near-near-far

Walking suture

34
Q

Describe a V-Y Plasty

A

V-shaped incision with the point of the V directed away from the defect to be closed

Close the original defect

Close V incision by converting it to a Y

Longer legs of the V make a greater degree of tension relief

Use for eyelid scar revision and closing elliptical defects

35
Q

What is a method of closing a circular skin defect

A

a. Suture along relaxing skin lines of tension then remove dog ears
b. Convert to X or Y
c. Excise 2 triangles on opposite sides, creating a fusiform defect; height of triangle should be equal to dimeter of the circle; removes skin of 1.5x original defect
d. Double S-shaped incision with bi-winged excision
e. Bow tie
f. Combined V incision

36
Q

Describe a bipedicle flap

A

Single longitudinal incision parallel to defect, or one incision on each side

Skin flaps approximately same width as original defect

Two sources of blood supply remain

Burrow’s triangles can be used to help with excess laxity/dog ears

Original defect is closed

New incision(s) are left open

37
Q

What is the difference between a rotation flap and a transposition flap

A

Rotation flap: Create semicircular incision and move tissue laterally to cover defect

Transposition flap: Rectangular, single pedicle flap created adjacent to defect and rotated on it’s pedicle. Can be rotated up to 180 degrees but rotation shortens flap

38
Q

State the advantages and disadvantages or polyglactin 910 and polydioxanone

A

Polyglactin 910:

  • Advantages:
  • Good size to strength ration
  • Greater initial breaking strength and stiffness than polyioxanone
  • Minimal tissue reaction
  • Excellent handing
  • Disadvantages:
  • May cut through friable tissue (esp. if not coated)

Polydioxanone:

  • Advantages:
  • Maintains tensile strength over prolonger period
  • (Less memory than polyglyconate)
  • Disadvantages:
  • Moderate knot security
  • Moderate handling
39
Q

What suture material should be used in the urinary tract

A

Polyglyconate or polydioxanone (if likely to be exposure to urine)

Poliglecaprone possible but not yer evaluated

40
Q

List the reasons for graft failure

A

Infection

Fluid accumulation

Motion

Inflammation

41
Q

Define serum imbibition and inosculation

A

Imbibition: Newly applied graft nourished by plasma-like fluid that passively enters open vessels of graft via capillary action

Inosculation: After 48hrs, new capillaries generated in recipient bed traverse fibrin layer to anastomose with those if graft

42
Q

Where can grafts be taken from

A

Full-thickness sheet grafts: Pectoral region

Split-thickness sheet grafts: Ventral abdomen and ventrolateral thorax behind elbow

Island grafts: Ventrolateral abdomen, perineum, area beneath mane

43
Q

What is the Modified Meek grafting technique

A

A combination of split-thickness sheet grafting and island grafting. Split-thickness sheet graft obtained and Meek micrografting equipment converts this to many micr grafts on a piece of gauze

44
Q

How should grafts be stored

A

Lay on sterile gauze swab with epidermis next to gauze

Roll up gauze-graft with gauze outside of roll

Place in sterile container with 1-1.25mL of storage medium per cm2 of graft

Check pH indicator: Cherry red to orange-yellow indicates excessive catabolites (apply graft or replace half of medium)

Can usually store until wound permits grafting

45
Q

Name and define the types of septic arthritis/osteomyelitis in foals

A

S-Type Infections:

Synovial membrane and fluid

foals <1 week

Multiple joints, most commonly stifle and hock

Acute lameness

Linked with FPT

E-Type Infections:

Articular epiphyseal complex (source of growth)

Several weeks of age

Multiple or single joints

Linked with FPT

May also have pneumonia/diarrhea

P-Type Infections:

Physis

+/- joint involvement

Weeks to a few months of age

Healthy foals

Distal physes of MCIII/MTIII and tibia common

One site usually

Streptococcus, Rhodococcus, Actinobacillus, E. coli, Salmonella

46
Q

What are the most common bacteria found in septic joints in foals and adults

A

Foals, type P: Streptococcus, Rhodococcus, Actinobacillus, E. coli, Salmonella

Adults after Injection/surgery:

Staphylococcus spp.

Traumatic injury:

E.coli (most common)

Salmonella (most common)

Staphylococcus

Pseudomonas

Yeast

Other fungi

47
Q

What are the methods of local antibiotic delivery

A

IO

IA (+/- pump)

RLP

Antimicrobial infused biomaterials

48
Q

What biomaterials can be used in local antibiotic delivery and define whether the are absorbable or non-absorbable

A

Biodegradable:

Collagen sponge

Plaster of paris

Hydroxyapatite

Dextran gel

Non-biodegradable:

PMMA

49
Q

How do you treat implant infections

A

Local AB delivery:AB beads:

PMMA good elution but non-absorbable (remove but rarely cause problem if left)

RLP:

Daily for as long as possible

Whole systemic daily dose

Large vessels, immediate compression, topical NSAIDs, Bandaging

Drainage of infected tissues:

Ultrasound guided incision

Surgical drain

Remove implants when sufficiently stabilized

If not sufficiently stable:

Remove implants, debride bone and replace autoclaved implants

Remove and manage fracture/arthrodesis with transfixation cast

Dynamic compression or tension device can restabilize site; empty screw holes filled with AB-impregnated collagen/dextran gel, POP

50
Q

What is the ethology of dentigerous cysts

A

Incomplete closure of first branchial cleft during embryologic development

51
Q

List the treatment options for sarcoids

A

Surgical Excision:

Least successful alone

Recurrence: 15.8-82%

Laser Ablation:

Less spread of cells

Recurrence: 38%

Combine with chemotherapy

Cryotherapy:

Success: 60-100%

Recurrence: 91% (success 9%) in another study

Thermocouples help

3x -30 degrees: Success: 68% to 85% if treatments repeated

Hyperthermia:

Spontaneous regress of non-treated tumors also

Radiotherapy:Iridium-192 implants

Success: 87.5-100%

Single dose

Brachytherapy: 86.6%

Hair/pigment loss, fibrosis, cataract formation, corneal ulceration

Gold-198 implants

Expensive

Hospitalization

Potentially hazardous

General anesthesia may be needed

Immunotherapy:

Mycobacterium cell wall extracts

Live whole-cell bacille Calmett-Guerin (BCG)

Propionibacterial cell wall extracts

Stimulated cell-mediated immuniting

Multiple intralesional injections

Higher success for smaller tumors

Severe local tissue swelling

Anaphylactic shock possible

Spontaneous regresson of untreated tumors can occur

Recurrence: 0-40%

Vaccination (tumor tissue) successful

Intralesional Cisplatin:

Success: 87%

Recurrence: 66%

Avoids systemic toxicity if in oil

Epinephrine can be added to emulsion (1:1000)

1mg cisplatin per cubic centimeter, minimum 4 treatments

Cytoreduction may help; injection does not affect wound healing

Intralesional TNF + xanthate successful

Topic Application of Chemotherapeutics:5-fluorouracil (5-FU):

Daily treatment

Success: 66%

AW3-LUDES

AW4-LUDES:

Success: 35%

Scarring occurs

Avoid eye

Bloodroot and zinc

Spontaneous regression of untreated tumors

Autogenous tumor vaccine (11/12 success)

If large, aggressive tumor, recommend combination of modalities:

Excision/laser ablation + chemotherapy/radiation therapy

52
Q

What are the treatment options for cutaneous habronemiasis

A

May resolve with cooler weather

Ivermectin (kill larvae but do not resolve skin lesion); oral ivermectin may increase pruritus

Large masses may require cytoreduction

Inralesional corticosteroids

Topic organophosphates or bandaging may prevent reinfection

Organophosphates, corticosteroids, DMSO, nitrofurazone have been used together

Ophthalmic form: oral ivermectin, topic corticosteroid eye drops (check cornea first), curettage

53
Q

What are the histologic feature of mast cell tumours

A

Benign, solitary, nodular cutaneous form is most common (inflammatory reaction to dysplastic mast cells and recruited eosinophils and granuloma develops)

Malignant (abnormal mast cells with increased nuclear-to-cytoplasmic rations, anisokaryosis and increased mitotic figures) and congenital forms possible

54
Q

What are the types of melanoma

A

Melanocytic nevi:

Large pleomorpic melanocytes with increased mitotic figures, binucleate cells and variable cytoplasmc pigmentation, single/multiple discrete nodules in grey and non-greys

Dermal melanomas:

Benign. Homogenous dendritic cells with condensed chromatin, dense pigmentation but no mitosis. Originate in deeper dermis, small single/multiple nodlues

Dermal melanomatosis:

Benign. Confluent multiple large melanomas. Risk increases with age. Risk of metastases

Malignant melanomas:

Rare. Invasive, poor prognosis

55
Q

Which structures can be affected in a heel bulb laceration

A

Skin

SubQ

Hoof wall

DFTS

DDFT

Navicular bursa

Navicular bone

Palmar cartilages

DIP jt

SDFT

Collateral suspensory ligaments of naivuclar bone

P3

56
Q

Name 3 nasty things that can occur with axillary lacerations

A

SubQ emphysema

Pneumomediastinum

Pneumothorax

57
Q

How is the proteolytic activity of chronic wound fluid different from acute wound fluid

A

Urokinase-type plasminogen activator and urokinase-type plasminogen activator receptors active in chronic wounds (plasminogen activator in acute wounds)

58
Q

What are differential diagnoses for chronic non-healing wounds

A

FB

Sinus tract

Fistula

Sequestrum

Infection

Sarcoid

Habronemiasis

Pythiosis

Other tumor

59
Q

What is the difference between a sinus tract and a fistula

A

FISTULA

Abnormal communication between two internal organs or from organ to body surface:

Synovial fistula

Enterocutaneous or parietal fistula

Orocutaneous or esophageal fistula

SINUS TRACT

Cavity or channel:

Normal, eg. Venous sinus

Pathologic, eg. Channel permitting escape of pus through skin

60
Q

Define creep (in relation to skin, not a person ) and what are the 2 types of creep?

A

Stress constant and strain increases with time

Mechanical creep:

Biomechanical property of skin, allowing it to stretch beyond it’s normal limits of extensibility under constant load

Straightening of collagen fibers parallel to stretching force

Biological creep:

Skin increases area by increasing epidermal mitotic activity, upregulation of blood vessels and increasing dermal cell numbers

Tissue expanders, hernias, subcutaneous masses

61
Q

Define relaxation

A

Strain constant and stress decreases with time

62
Q

What is the minimum distance from the skin edge of a traumatic wound that skin sutures should be placed?

A

0.5cm

63
Q

Which is preferable: Increasing suture number or suture material size?

A

Increasing suture numbers

64
Q

What are the advantages and disadvantages of simple interrupted sutures?

A

Advantages:

Excellent tissue apposition

Can vary width if irregularly shaped wound

Can adjust tension on individual sutures

Greater tensile strength and less compromise of microvasculature than simple continuous patterns

Can combine with other patterns

Disadvantages:

Placement too far back or too much tension leads to to inversion

65
Q

What are the advantages and disadvantages of simple continuous sutures?

A

Advantages:

Quick

I would add that in line alba this is stronger but Auer didn’t list this

Disadvantages:

Knot failure or suture breakage results in breakdown

Cannot vary tension

Increased edema

Compromised circulation

Prolonged inflammatory phase of wound healing

Lack of precise apposition