Antimicrobials

Question 1

Describe the mechanism of action of the following antimicrobials and state whether the are bactericidal or bacteriostatic: a. Chloramphenicol b. Ceftiofur c. Gentamicin

Answer 1

a. Chloramphenicol inhibits protein synthesis by binding to 50S ribosomal subunit - bacteriostatic b. Ceftiofur disrupt cell wall synthesis - bactericidal c. Gentamicin binds to 30S ribosomal subunit, preventing protein synthesis - bactericidal

Question 2

Describe the mechanism of action of the following antimicrobials and state whether the are bactericidal or bacteriostatic: a. chloramphenicol b. ceftiofur c. gentamicin

Answer 2

a. chloramphenicol inhibits protein synthesis by binding to 50S ribosomal subunit - bacteriostatic b. ceftiofur disrupt cell wall synthesis - bactericidal c. gentamicin binds to 30S ribosomal subunit, reventing protein synthesis - bactericidal

Question 3

What is the mechanism of action of Metronidazole

Answer 3

Inhibits nucleic acid synthesis by disrupting DNA

Question 4

What is the mechanism of action of erythromycin

Answer 4

Binds to 50S ribosomal subunit

Question 5

What is the mechanism of action of enrofloxacin

Answer 5

Inhibits DNA gyrase

Question 6

What is the mechanism of action of Amikacin

Answer 6

Binds to 30S ribosomal subunit

Question 7

What is the mechanism of action of Trimethoprim sulphonamide

Answer 7

Inhibits folate synthesis via dihydrofolate reductase