Wound healing and Repair

Question 1

What is repair?

Answer 1

When the body attempts to restore normal structure and function when tissue is injured.

Question 2

List the 3 proliferative capacities of tissues:

Answer 2

1. Labile tissues
2. Stable tissues
3. Permanent tissues

Question 3

What is the difference between regeneration and healing/repair?

Answer 3

Regeneration can occur when tissues are composed of cells with proliferative capacity and the underlying structure of the tissue has not been too severely damaged, whereas repair occurs when tissues are composed of cells with limited or no proliferative capacity or the underlying structure of the tissue is lost.

Question 4

What are the 4 steps of tissue repair by connective tissue?

Answer 4

1. Formation of new blood vessels (angiogenesis)
2. Migration and proliferation of fibroblasts
3. Deposition of ECM (scar)
4. Maturation and reorganization of the fibrous tissue (remodelling).

Question 5

List the 6 factors that affect healing:

Answer 5

1. mechanical
2. location
3. infection
4. nutrition
5. poor perfusion (blood supply)
6. foreign bodies

Question 6

What are 4 complications of healing?

Answer 6

• Wound dehiscence (splitting)
• Exuberant granulation
• Keloid formation/hypertrophic scar
• Contraction