Immune mediated Injury Flashcards
1
Q
Define self tolerance:
A
The lack of an immune responsiveness to one’s own tissue antigen.
2
Q
What does AIRE do?
A
AIRE is a transcription factor expressed in the medulla of the thymus. It is part of the mechanism which eliminates self-reactive T cells that would cause autoimmune disease.
3
Q
What are the 4 mechanisms of peripheral tolerance?
A
- Anergy
- Suppression
- Deletion
- Ignorance
