Wound Healing Flashcards
Wound
A cut or break in continuity or any tissue caused by injury or operation. They can be both internal or external.
Local factors affecting repair
Infection, poor blood supply, foreign bodies, movement, type, size and location
Systematic factors affecting repair
Age, nutrition, uncontrolled diabetes, haematological disorders
How does age affect repair?
Due to reduced elasticity and degranulation of elastic tissue and collagen fibres in the dermal layer.
How does nutrition affect tissue?
Deficiency of vitamin c, proteins and zinc all play a role in the formation of collagen
How does uncontrolled diabetes affect wound healing?
It makes them more prone to develop infection, they may develop poor circulation hence a delay in healing
What haematological disorders affect wound healing?
Neutropenia and bleeding disorders that slow the healing process.
What tissue recovers well?
Skin and connective tissue
Why does skin and connective tissue heal well?
They contain stem cells, undifferentiated cells that can divide and renew the cells that have died
What is stable tissue?
The liver
How does stable tissue recover?
By having mature, differentiated cells divide or regenerate
What is permanent tissue?
Muscle, cartilage and cardiac tissues
Why does stable tissue take time to heal?
They lack stem cells and cannot replicate
Primary intention
Wound edges come together and the stem cells in the epidermis are bought close together, regenerating the damaged tissue leaving and minimal scar.
Secondary intention
Occurs when the wound edges are too far from one another. The stem cells do not approximate, so the wound is replaced by connective tissue that grows from the base of the wound upwards.
Tertiary intnetion
A wound is cleaned and left open due to an increased chance of being contaminated by bacteria. If its closed too early, bacteria can be trapped, leading to abscess or infection.
Types of tissues
Epithelial tissue, connective tissue, muscular tissue, nervous tissue.