Crohn's Disease

Question 1

Crohn’s diesease

Answer 1

Inflammation of the digestive system that causes inflammation and tissue disruption anywhere along the GI tract

Question 2

Two areas crohn’s disease most commonly affects

Answer 2

The ileum or colon

Question 3

The ileum

Answer 3

The coiled part of the small intestine that connects to the large intestine. The mucosa is highly folded, increasing the surface area of absorption.

Question 4

The colon

Answer 4

Part of the large intestine that reabsorbs fluids and processes waste products from the body to prepare for its elimination

Question 5

Causative agents

Answer 5

Bacteria, virus, diet

Question 6

Modifying factors

Answer 6

Genetics, environment

Question 7

Impact on the epithelial barrier of crohns

Answer 7

The genetic defect makes it easy for the pathogens to get through, causing the immune system to be activated and leading to the unregulated inflammation.

Question 8

Granuloma

Answer 8

A big mass of immune cells

Question 9

Symptoms of crohns

Answer 9

Nausea, vomiting, abdominal pain and tenderness, dehydration, weight loss and faltering growth, fatigue, anaemia, fever, malabsorption and diarrhoea and blood stool

Question 10

Reasons for malabsoption in crohns

Answer 10

Unable to absorb nutrients from the diet if the small intestines are damaged as they play an important role in absorbing nutrients

Question 11

Reasons for diarrhoea and bloody stool in crohn’s

Answer 11

Damaged intestinal wall tissue, if the cells in the lower intestines are damaged, they loose their ability to dissolve water, so more water is needed to be excreted.

Question 12

Treatment for crohn’s

Answer 12

Steroids, immunosuppressants, liquid diet, antibiotics, surgery

Question 13

Benefit of steroids on crohn’s

Answer 13

Relieve symptoms by reducing inflammation in the digestive system

Question 14

Benefits of immunosupressants on crohns

Answer 14

Reduce the activity of your immune system

Question 15

Benefits of liquid diet on crohns

Answer 15

Helps to reduce symptoms and contains all the nutrients needed

Question 16

Benefits of antibiotics on crohn’s

Answer 16

Reduce gut bacteria in the intestines and reduce the immune response as they can be anti-inflammatory

Question 17

Benefits of surgery on crohns

Answer 17

Relieves symptoms although they will usually return elsewhere

Question 18

Reasons for a ilesotomy stoma in crohn’s

Answer 18

If inflammation is severe and there is infection, the section removed may not be healthy enough to be joined back together, so part of the bowel is bought out onto the external skin until it has healed

Question 19

Cytokines

Answer 19

Cell signalling molecules secreted by cells in the immune system

Question 20

Types of surgery to treat crohn’s

Answer 20

Resection, ileostomy, draining abscesses, balloon dilation

Question 21

Resection surgery in crohns

Answer 21

A surgical procedure to remove a portion of the small or large intestine that has been damaged by the crohns. The diseased section is removed and the two healthy ends are joined together

Question 22

Why does crohn’s cause a fever?

Answer 22

Due to the production of pyrogens during the inflammatory response

Question 23

Strictures

Answer 23

The major narrowing of the intestinal wall that limits the flow of the GI contents which can lead to obstructions