Wound Healing

Question 1

Name the four phases of wound healing

Answer 1

hemostasis, inflammation, migration/proliferation, remodeling

Question 2

Name the components of the migration/proliferation phase of wound healing

Answer 2

angiogenesis, epithelization, contraction, fibroplasia

Question 3

Cells that are the major source of stimulatory signals for wound healing

Answer 3

macrophages

Question 4

Process where endothelial buds progress toward wound space and immature vessels differentiate into capillaries, arterioles, and venules

Answer 4

angiogenesis

Question 5

Process where keratinocytes migrate across wound differentiating and causing stratification of neodermis. Aided by moist environment

Answer 5

epithelization

Question 6

Process where fibroblasts migrate into the wound site and replicate, synthesizing and depositing collagen and proteoglycans.

Answer 6

fibroplasia

Question 7

Defined as changes in wound matrix composition over time (extracellular matrix–>collagen–>scar).

Answer 7

remodeling

Question 8

Cells involved in remodeling process

Answer 8

fibroblasts

Question 9

Principles that include gentle handling of tissues, careful hemostasis, asceptic technique, avoidance of tension, sharp dissection, obliteration of dead space

Answer 9

Halsted’s

Question 10

type of wound healing often used if there has been contamination, it’s infected, or in peritonitis

Answer 10

secondary intention

Question 11

Advantages of a wound VAC

Answer 11

decreased edema, increased granulation/vascularity, and lower bacterial counts

Question 12

Oral antibiotic prophylaxis for colorectal surgery

Answer 12

neomycin + erythromycin with bowel prep

Question 13

IV regimens for colorectal surgery

Answer 13

cefoxitin or cefazolin + metronidazole