Workshop 10 - Benign and Malignant connective tumors

Question 1

Connective tissue tumors are composed of differentiated connective tissues of the body:

Question 2

Connective tissue tumors originate in :

Answer 2

primitive presursor cells :
Pluripotente mezenchimal cells

Question 3

Benign connective tumors

def. name. macro

Answer 3

Are tissue proliferations that reproduce the structure and function of the tissue of the origin

name : -oma to connective tissue

Macro:
nodular, well defined - with or without capsule

Question 4

Malignant connective tumors

def.name.

Answer 4

Are tissue proliferations that have lost the abolity to differentiate.

name : -sarcoma

less common than carcinomas,
but more common in children and young people

Question 5

Malignant tumors
Macro

Answer 5

Sarcomas are :

deep tumoral masses, white-pinkish ( like fresh fish )

bulky, unencapsulated or pseudo-capsuled

locations : deep tissues of extremities,
retroperitoneal sites

Question 6

Malignant connective tumors

Micro

Answer 6

Hypercellular tumors , with varying degrees of differentiation
They contain sarcomatous vessels and give early hematogenous metastases.

Question 7

Criteria for malignancy in assessing of histological grade are :

Answer 7

• cellular and nuclear polimorphism
• mitotic activity
• presence of necrosis

Question 8

prognosis of tumors

is made in relation to :

Answer 8

• location
• tumor stage
  ( size, local invasion, hematogenous metastases )
• histological grade of malignancy
  degree of tumor differentiation
  and tumor cell mitotic activity

Question 9

Sarcomas degrees of differentiation

Answer 9

degree I : low
degree II : moderate
degree III : high

Question 10

2 major types of tumors ( according to the degree )

Answer 10

• low malignancy
  ( WD well differentiated )
  grow slowly, local invasion, rare metastasis
• high grade of malignancy
  ( MD, PD )
  grow fast, invasive tumors, rapid metastasis

Question 11

Benign connective tumors

( 5 )

Answer 11

• leiomyoma
  ( smooth muscle )
• Lipoma
  ( fat tissue )
• Chondroma
• Osteoma
• Hemangioma

Question 12

Leiomyoma

def.macro.micro

Answer 12

tumor of smooth muscle

Macro
nodular tumor, single or multiple,
1-2 cm , without capsule

Micro
without capsule, composed of fascicles of mature smooth muscle fibers

the tumor suffers :

1. mixomatous degeneration
2. fibrous change

( usually in uterus , GIT )

Question 13

Lipoma

def.location

Answer 13

Benign tumor composed of mature adipose tissue
Locations: Various

• Superficial : subcutaneous areas
• Deep : intramuscular areas

Question 14

Lipoma subcutaneous adipose tissue

Answer 14

Macro :
With capsule
tumor is yellow and has lobular appearance in cut sect.

Micro
encapsulates , consisting of mature adipose tissue
and connective - vascular axes

Question 15

Chondroma

def. originates from:

Answer 15

Is a benign tumor consisting of mature hyaline catilagonous tissue

Originates from :

1. cortex of metaphyseal short bones ( hands feet )
2. intrabone cartilage of distal extremities
   ( any bone )

Question 16

chondroma

macro, micro

Answer 16

macro :
nodular , well circumscreibed
blue and translucent of 3cm

Micro:
nodular, encapsuled , well circumscribed
composed of mature hyaline cartilage and
connective vascular axes