Workgroup 3 Hematopoiesis and plasticity

Question 1

How is NK cell developed from the hematopoietic cells?

Answer 1

• the pluripotent hematopietic cells differentiates into common lymphoid cell precursor with the help of IL-17
• IL-2 and IL-17 differentiatesit into common T-cell/ILC precursor
• the common ILC precursor is differentiated into Nk cell by transcription factor Tbet