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advanced immunology > mindmapping, workgroup 1 > Flashcards

mindmapping, workgroup 1 Flashcards

1
Q

What do Th1 produce?

A

IL-2
TNF-alpha
IFN-gamma
GM-CSF

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2
Q

What are the transcription factors of Th1?

A

Tbet
STAT 1 and 4

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3
Q

What cells do Th1 activate?

A

Proinfammatory macrophages

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4
Q

What are the cytokines that induce the differentiation into Th1?

A

Il-12
IFN-gamma

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5
Q

What is the function of Tfh?

A

activating/help B-cell differentiation

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6
Q

What are the transcription factors of Tfh?

A

Bcl-6 and STAT3

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7
Q

What cytokines induce Tfh?

A

IL-6
IL-21

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8
Q

What are the effector molecules of Tfh?

A

IFN-gamma
Il-21
Il-4

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9
Q

What is the function of Th17?

A

recruitment of neutrophils and enhances clearance of pathogens

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10
Q

What are the transcription factors of Th17?

A

Ror-yt
STAT3

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11
Q

What are the effector molecules of Th17?

A

IL-22
IL-17
IL-21
IL-26

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12
Q

What is the surface marker of Th17?

A

CCR6

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13
Q

What cytokines induce Th17?

A

IL-22
IL-23
TGF-B
Il-6

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14
Q

What is the function of Treg?

A

closes dowwn CD4 and 8 cells to prevent further inflammation and tissue damage, promotes cancer

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15
Q

What are the transcription factors of Treg?

A

Foxp3
STAT5

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16
Q

What cytokines induce Treg?

A

IL-2
CD28
TGF-B

17
Q

What are the effector molecules of Treg?

A

IL-35
IL-10
TGF-B

18
Q

What is the function of Th2?

A

activates mast cell, basophils and eosinophils against parasitic infections.

19
Q

What cytokines induce Th2?

A

IL-4

20
Q

What are the effector molecules of Th2?

A

TGF-B
Il-10
IL-4
IL-5
IL-13

21
Q

What is the transcription factor of Th2?

A

GATA3

22
Q

What is the transcription factor of TH9?

A

Pu1
IRF4
STAT6

23
Q

What is the effector molecule of Th9?

A

IL-9?

24
Q

What are the surface markers of Th9?

A

CCR3
CCR6
CXCR3

25
Q

What does Th9 respond to?

A

IL-2
IL-4
TGF-B

advanced immunology (3 decks)

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