womens health 1 Flashcards
what is Hydroxyprogesterone?
- An androgen
what is androstenedione?
- An androgen
what is estrone?
- Estrogen
Estrogen response elements, androgen response lelement and progesterone response element regulate gene transcription. TRUE OR FLASE?
TRUE
Estrogen acts a signalling molecule by binding to specific target cells. TRUE OR FALSE?
TRUE
what are ER used in?
- Contraception
- Pre and post menopause prblems (HRT)
- treatment of breast cancer
ER acts a signalling molecule for heart, breast, liver. true or false?
true
the receptor undergoes dimerization in order for it to increase affinity for the EREs and regulate gene expression. TRUE OR FALSE?
TRUE
What do progestins do?
- Interact with PR and mimic the stimulatory effecst of progesterone
Mifeprestone is a PR antagonist. TRUE OR FLASE?
TRUE
Mifeprestone is used to terminate pregnancy. TRUE ORF ALSE?
TRUE
Theca secretes testosterone
Antrum contains estrogen
Granulosa converts testosterone to estrogen. TRUE OR FALSE?
TRUE
FSH stimulates several follicle release and secretion of estradiol. TRUE OR FALSE?
TRUE
Folicles causes low levels of estradiol which leads to endometrial contraction leading to menstration, here LH is inhibited and FSH is stimulated. TRUE OR FLASE?
TRUE
FSH and LH are released from pituitary. TRUE OR FLASE?
TRUE
GnRH is secreted from the hypothalamus. true or false?
true
What are the key sex female hormones?
- Progesterone
- Estrogen
what produces HCG if pregnancy occurs?
- Blastocyst
What does HCG do?
- It support continued release of progestetone during pregnancy by the corpus luteum until the placenta takes over
what does progestrone do, during pregnancy?
- It maintains uterine lining
- Impotant for the growth of blood vessels
what occurs menopause?
- when all fofflicles have been depleted
- decreases estrogen levels which inhibits LH and FSH release
where is progesterone secreted from?
the copus luteum
what are the three phases of the reproductive cycle?
- Follicular
- Late follicular/ovulation
- Luteal phase
What occurs in the follicular, late follicular/ ovulation and luteal phase?
- Follicular:
- FSH and LH released by pituitary in the brain
- FSH causes follicles to develop and released
- FSH also decreases levels of estradiol
Late/follicular/ovulation:
- FSH stimulating one follicle
- Inceased estradiol which leads to a surge in LH
- Surge in LH stimulates ovulation
- GnRH causes further spike in LH
Luteal phase:
- High levels of LH leads to corpus luteum
- Corpus luteum secretes progestetrone and estradiol which maintain lining of endometrium
- This blocks secretion of GnRH from hypthalamus and FSH and LH from the pituitary
