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David's mottershead > Men's health > Flashcards

Men's health Flashcards

1
Q

LH targets leydig cells stimulating testosterone secretion. true ro false?

A

true

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2
Q

FSH tagets sertoli cells and spermatogonia. true ro false?

A

true

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3
Q

If sertoli is damage it can lead to infertility. true or false?

A

true

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4
Q

what does testosterone target?

A
  • The brain
  • Primary and secomdary sexual characteristics
  • muscles
  • development of gametes
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5
Q

what does prostate galnd do?

A

secretes thin alkaline solution to neutralise urine and female system

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6
Q

hameodynamic pathway control erections. true or false?

A

true

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7
Q

what are the nerves innervating the penis?

A
  • Sympathetic, parasympathetic, somatic and sensory innervation
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8
Q

what are the causes of erectyle dysfunction?

A
  • Psychogenic
  • Neurogenic
  • Arteriogenic
  • Venogenic
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9
Q

what drugs are used to treat ED?

A
  • Alprostadil (prostangladin E1)
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10
Q

what is the PK, ADR and side effects for Alprostadil?

A
  • PK - low systemic exposure
  • ADR- deformation of penis
  • Side effects- hypotension
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11
Q

name some PDE-5-Inhibitors?

A
  • Sildenafil (Viagra), vardenafil, Tadalafil
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12
Q

what is the major metaboliser for PDE-5-inhibitors?

A

CYP3A4 for all PDE-5-Inhibitors

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13
Q

Tadalafil has longest half life of PDE-5-inhibitors. true or false?

A

true

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14
Q

what are the two ways of achieving specificity?

A
  • Pharmacological

- Pharmaceutical approaches

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15
Q

what are the pharmacotherapy for benign prostatic hyperplasia?

A
  • Disease progression arrest

- Symptomatic relief

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16
Q

what are the causes of male urinary tract symptoms?

A
  • Age

- Physiological systems involved

17
Q

what are the causes of BPH?

A
  • Compression of urethra
  • Presence of bothersome LUTS
  • Enlargement of gland
18
Q

how do a1 adrenergic blockers work to treat BPH?

A

Relax smooth muscle in the prostate producing an increase in urinary flow rate; no effect on prostate size

19
Q

how do 5 a-reductase inhibitors work for treatment of BPH?

A
  • Prevent conversionof circulating testosterone to more potent dihydrotestosterone
20
Q

what is prostate growth driven by?

A

-androgens

21
Q

Onset of benefits slow for 5 a-reductase inhibitors. true or false?

22
Q

what are the side effects of 5 a-reductase inhibitors?

A
  • reduced libido
23
Q

5-a-Reductase Inhibitors:Arrest Disease Progression.
Alpha-Blockers: Relieve Symptoms Rapidly
True or false?

David's mottershead (3 decks)

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