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Women's health drugs Flashcards

(74 cards)

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1
Q

Methyldopa class

A

AntiHTN

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2
Q

Methyldopa MOA

A

Central alpha-adrenergic inhibitor

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3
Q

Methyldopa indication

A

HTN in PG

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4
Q

Labetalol class

A

AntiHTN

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5
Q

Labetalol MOA

A

A1/B1/B2 blocker

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6
Q

Labetalol indication

A

DOC for HTN in PG

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7
Q

Folic acid class

A

Water soluble VIT

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8
Q

Folic acid MOA

A

Required for formation of multiple co-enzymes in protein synthesis. Provides folate for DNA synthesis

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9
Q

Folic acid indications

A

Prevention of neural tube defects

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10
Q

Folic acid contraindication

A

Untreated B12 deficiency

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11
Q

Pyridoxine class

A

VIT B6

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12
Q

Pyridoxine MOA

A

Inhibits CRTZ; decreases vestibular stimulation, decreases labrynth function

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13
Q

Pyridoxine indication

A

In combo with doxylamine (an antihistamine) for N/V in PG

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14
Q

Pyridoxine side effect

A

Sedating

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15
Q

Pyridoxine contraindication

A

Narrow angle glaucoma

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16
Q

Magnesium Sulfate

A

Tocolytic agent

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17
Q

Mg++ sulfate MOA

A

Decreases Ach in motor nerve terminals
Slows rate of SAN impulse formation
Relaxes bronchial smooth muscle

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18
Q

Mg++ sulfate indications

A

Preterm labor/eclampsia
Torsades
Refractory pediatric status asthmaticus

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19
Q

COCs…MOA

A

Suppression of FSH/LH with suppression of ovulation and implantation; thickening of cervical mucus; slowing of tubal motility

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20
Q

COCs indication

A

Contraception…some have added benefit of regulating menses or mitigating menopausal sxs

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21
Q

COC side effects: excess estrogen

A

bloating
migraines
decreased libido
wt gain

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22
Q

COC side effects: deficient estrogen

A

spotting
amenorrhea
vaginal dryness

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23
Q

COC side effects: excess progestin

A

acne
increased appetite
fatigue
hirsutism

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24
Q

COC side effects: deficient progestin

A

amenorrhea

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25
COC absolute contraindications
``` Hx of... Thromboembolism CVD/CAD Breast CA estrogen-dependent neoplasm unDx'd uterine bleeding PG smoking >15 cigs/day and >35 y/o migraines with aura hepatic disease/tumor ```
26
COC relatice contraindications
Smoking
27
COC Dx-Dx interactions
``` Anticonvulsants Benzos Corticosteroids PCNs Protease inhibitors Rifampin St. John's wort ```
28
What CYP subsrate is EE?
CYP3A4
29
Monophasic COC
Loestrin Fe 1/20
30
Biphasic COC
Lo Loestrin Fe
31
Triphasic COC
Triphasil
32
Quadraphasic COC
Natazia
33
You have to take tri- and quadraphasic COCs at the same time every day to prevent...
breakthrough bleeding
34
Triphasil is also indicated to treat...
menopausal sxs
35
Progestin-only BCPs MOA
Prevents mid-cycle FSH/LH surge inhibits ovulation and implantation thickens cervical mucus slows tubal transport
36
Progestin only BCPs indication
Contraception - a good choice for women who can't take COCs
37
Pros of Progestin only BCPs
Less risk of blood clots | minimized menses after 6-9 cycles
38
Cons of progestin only BCPs
More breakthrough bleeding | must take at the same time every day for efficacy
39
Progestin-only BCP
Ovrette
40
Extended cycle BCP
Lybrel
41
Quadraphasic extended cycle BCP
Quartette
42
In addition to contraception, Lybrel and Quartette are good for...
menstrual-related sxs
43
Conjugated Equine estrogen
Estrogen suppliment
44
CEE indications
moderate to severe vasomotor sxs, vaginal mucosal atrophy
45
CEE contraindications
VTE, breast CA, stroke, PG, unDx uterine bleeding
46
CEE Dx-Dx interactions
CYP3A4 inducers decr [CEE] | CYP3A4 inhibitors incr [CEE]
47
CEE black box warning
CVA, dementia, malignancies, etc
48
Depot MPA
Progestogen
49
Depot MPA indication
Contraception - good for women who have a contraindication for EE
50
How long can amenorrhea/infertility last after you D/C Depot?
12-18 months
51
What is a potential consequence for continued, long term use of Depot?
Decreased BMD
52
Mifepristone: class
Abortifactant
53
Mifepristone: MOA
Inhibits progesterone receptors - antagonizing endometrium and myometrium
54
Mifepristone: indication
Early PG terminiation
55
Mifepristone: contraindications
Ectopic PG IUD in place bleeding d/o
56
Mifepristone: black box warning
Bleeding and infection
57
Ulipristal: class
Post exposure contraception
58
Ulipristal MOA
Binds to progesterone receptors, inhibiting or delaying ovulation; alters endometrium
59
Ulipristal indication
emergency contraception
60
Ulipristal side effects
N/V | If vomiting occurs w/in first 3 hours, you may need to re-adminiater
61
Can Ulipristal be given to women who can't take COCs?
Yes
62
Flibansterin: class
Mixed 5-HT1A agonist/5-HT2A antagonist
63
Flibansterin MOA
Unknown
64
Flibansterin indication
Hypoactive sexual desire d/o in premenopausal women
65
Flibansterin side effects
CNS depression | HOTN/syncope
66
Flibansterin contraindications
ethanol | liver dz
67
How much does 30 days worth of Flibansterin cost
$960
68
Osphema class
Selective estrogen receptor modulator
69
Osphema MOA
Selective activation/inhibition of estrogen pathways in different tissues
70
Osphema Indication
Dyspareunia secondary to vulvar/vaginal atrophy in post menopausal women
71
Osphema side effects
Hyperydrosis, hot flashes, endometerial proliferation
72
Osphema contraindications
Abnormal vaginal bleeding DVT/PE/blood clots Estrogen-dependent tumor PG
73
Osphema should be administered with...
food
74
How much does 90 days worth of Osphema cost?
$600

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