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Endocrine Pharmacology > WK4 (Female) > Flashcards

WK4 (Female) Flashcards

1
Q

Leuprolide is what?

A

GnRH Agonist

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2
Q

Ganirex is what?

A

GnRH Antagonist

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3
Q

Cetrorelix is what?

A

GnRH Antagonist

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4
Q

GnRH agonist Pulsatile vs. Non-pulsatile administration?

A

Pulsatile causes FSH and LH release

Non-Pulsatile causes HPA shut down with transient FSH/LH increase

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5
Q

Uses of Leuprolide?

A

Shut down HPA during ovulation for follicle stimulation
Reduce Uterine Fibroid symptoms
Control hormone dept Prostate and Breast Cancer

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6
Q

Use of Ganirex or Cetrorelix?

A

Prevent endogenous LH during folliculogenesis induction
Prostate and Breast Cancer
Benign Uterine Disease

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7
Q

Menotrophin is what?

A

Purified human FSH and LH gonadotrophin

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8
Q

Urofolitropin is what?

A

Purified Human FSH

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9
Q

Follitropin is what?

A

Recombinant human FSH

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10
Q

Uses for FSH/LH gonadotrophins?

A

Folliculogenesis
Hypothalamic non-function
Superovulation in normal women

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11
Q

Gonadotropin Side Effects?

A

Multiple Fetuses

Ovarian Hyperstimulation Syndrome

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12
Q

Ovarian Hyperstimulation syndrome?

A

Fluid shift to abdominal and thoracic cavity causing hypovolemia, ascites, bloating

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13
Q

Risk factors for OHSS?

A 
Young
Low BMI
High Dose FSH/LH
High serum Estrogen
Previous OHSS
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14
Q

Clomiphene Citrate is what?

A

Estrogen R agonist (SERM)

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15
Q

Clomiphene Citrate use?

A

Folliculogenesis

Polycystic Ovarian Syndrome

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16
Q

Clomiphene Citrate contraindications?

A

Liver failure

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17
Q

Clomiphene Citrate toxicity?

A

Hot Flashes

OHSS

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18
Q

Drugs for folliculogenesis?

A

Gonadotropins

  • Menotropin
  • Urofolitropin
  • Follitropin

Clomiphene Citrate

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19
Q

Drugs for ovulation induction?

A

1st. Gonadotropin or Clomphene

2nd. hCG

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20
Q

Tamoxifen is what?

A

SERM
Agonist and Uterus, bone, Lipoprotein
Antagonist in Breast and vasculature

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21
Q

Raloxifene is what?

A

SERM
Agonist in bone and lipoprotein
Antagonist in breast and uterus

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22
Q

Toremifiene is what?

A

SERM
Agonist at uterus
Antagonist at breast

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23
Q

SERM uses?

A

ER+ Breast Cancer

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24
Q

Which SERM for Pre-menopausal women with ER+ breast Cancer?

A

Tamoxifen

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25
Q

Which SERM for ER+ cancer prevention?

A

Raloxifene

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26
Q

SE of SERMs?

A 
Nausea, vomiting
Rash
Hot flashes
Thrombi
Endometrial Cancer
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27
Q

Fulvestrant is what?

A

SERD (Selective Estrogen Receptor Downregulator)

Pure antagonist

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28
Q

Fulvestrant use?

A

ER+ Breast Cancer

29
Q

Fulvestrant administration?

A

IM injection

30
Q

Fulvestrant SE?

A

GI
Hot Flashes
Thrombi

31
Q

Anastrozole is what?

A

Non-Steroid
Reversible
Aromatase Inhibitor

32
Q

Exemastane is what?

A

Steroidal
Non-reversible
Aromatase Inhibitor

33
Q

Aromatase inhibitors used for what?

A

ER+ breast cancer

34
Q

Aromatase inhibitors SE?

A

Hot Flashes

Unknown long term concequences

35
Q

Letrozole is what?

A

Non-steroid
Reversible
Aromatase Inhibitor

36
Q

Ethinyl Estradiol use?

A

Oral Contraception

HRT

37
Q

Estradiol Valerate Use?

A

Injection
Topical HRT
Vaginal Ring

38
Q

Absolute Estrogen Contraindications?

A 
PE
CAD
Eestrogen Tumor
Liver Disease
Undiagnosed Uterine Bleed
Smoker >35yrs old
Migranes + Aura
39
Q

Estrogen Benefits?

A 
Decreased Flow
Reduced ovarian, endometrial , colorectal cancers
Improved acne
Improve osteoporosis
Decreased Ectopic pregnancy
40
Q

Estrogen risks?

A

Thrombi
Cervical Cancer
Medicine interactions
Breast Cancer (Unproven)

41
Q

Norethidrone is what?

A

2nd gen Progestin Estrane

42
Q

Levonorgestrel is what?

A

2nd gen Progestin Gonane

43
Q

Norgestimate is what?

A

3rd gen Progestin Gonane

44
Q

Desogrestel is what?

A

3rd gen Progestin Gonane

45
Q

Medroxyprogesterone Acetate is what?

A

Injectable Progestin Progestane

46
Q

Progestins used in combo oral contraception?

A

Norethidrone
Levonorgestrel
Norgestimate
Desogestrel

47
Q

Etonogestrel is what?

A

Implantable progestin rod

48
Q

Who uses progestin only oral contraception?

A

Patients with estrogen contraception
Nursing Moms
Patients with SE to combo contraception

49
Q

Progestin only oral contraception SE?

A

Amennorhea
Androgen effects
Breakthrough ovulation
Osteoporosis

50
Q

Estrogen or Progesterone causes androgen effects?

A

Progesterone

51
Q

Androgen effects?

A

Increased LDL
Decreased HDL
Acne
Hirsutism

52
Q

Early gen progestin with least androgenic effects?

A

Norethidrone

53
Q

Specific SE of late gen progestins

(Norgestimate, Desogestrel)?

A

Less Androgenic

More Thrombi

54
Q

Benefits of progestin only oral contraception?

A

Amennorhea
NO RISK OF THROMBI
Reduced risk of endometrial cancer
Fast return to fertility

55
Q

Progestin used for injection?

A

Medroxyprogesterone Acetate

56
Q

Black box with medroxyprogesterone acetate?

A

Bone health

Longest return to fertility

57
Q

Implantable progestin rod?

A

Etonogestrel

58
Q

Progestin used in Plan B?

A

Levonorgestrel

59
Q

Progestin used in IUDs?

A

Levonorgestrel

60
Q

Ulipristal Acetate is what?

A

Progesterone Antagonist

61
Q

Mifepristone is what?

A

Progesterone Antagonist

62
Q

High does vs low dose mifepristone?

A

Low dose = inhibits ovulation

High Dose = abortifacient

63
Q

What is added to oral E/P pills to reduce wt gain?

A

Drospirenone (spironalactone analog)

64
Q

Drospiredone SE?

A

More thrombi

Hyperkalemia

65
Q

Dienogest is marketed as an OC for what specific purpose?

A

Heavy irregular menses

66
Q

Relative contraindications of estrogen?

A 
Obesity
Thrombophilia
Anti-convulsants
Migrane w/o aura
HTN
Depression
Lactation
67
Q

Estrogen methods of delivery?

A

Pill
Ring
Patch (More breakthrough bleeding)

68
Q

Ulipristal acetate is effective for how long after intercourse?

A

120 hrs (Stops ovulation)

Endocrine Pharmacology (5 decks)

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