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Endocrine Pharmacology > WK1 > Flashcards

WK1 Flashcards

1
Q

Omnitrope is what?

A

rhGF

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2
Q

Nutropin is what?

A

rhGF

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3
Q

Norditropin is what?

A

rhGF

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4
Q

Genotropin is what?

A

rhGF

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5
Q

Siazen is what?

A

rhGF

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6
Q

Mescarin is what?

A

rhIGF1

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7
Q

Mescarin Rinfabate is what?

A

rhIGF1 + IGF1BP

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8
Q

When do you use rhGF?

A

For hyposecretion of GH
SHOX
Hypopitutarism

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9
Q

When do you use rhIGF1?

A

For Laron Syndome GF problems

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10
Q

Why rhIGF1 instead of rhGF?

A

Because Laron Syndrome is a defect in the GH receptor so recombinant GH won’t work. IGF attenuates well enough

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11
Q

SE of rhGF?

A

Ab production (No consequence)
Scoliosis
Diabetogenic

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12
Q

SE of rhIGF1?

A

Hypoglycemia

CYP induction

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13
Q

When shouldn’t you use rIGF?

A

Cancer

For growth if epiphyseal plates are closed

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14
Q

Bromocriptine is what?

A

DA analog

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15
Q

Octreotide is what?

A

SST analog

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16
Q

Pegvisomant is what?

A

GH antagonist

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17
Q

What are treatment options for hypersecretion of GH?

A

DA analog
SST analog
GH Receptor Antagonist

18
Q

SE of Octreotide?

A

Diarrhea
Flatulence
Malabsorption

19
Q

SE of Pegvisomant?

A

Ab formation

Liver Toxicity

20
Q

Cabergoline is what?

A

DA agonist

21
Q

Cabergoline is most effective for what disease?

A

Hypersecretion of prolactin

- Shrinks Tumor

22
Q

SE of Cabergoline

A

Nausea, vomiting, dizziness, hypotension
Stroke
Psych manifestations

23
Q

Levothyroxine is what?

A

T4 analog

24
Q

Liothyronine is what?

A

T3 analog

25
Q

Methimazole is what?

A

Thiamide that blocks Thyroid Peroxidase

26
Q

Carbimazole is what?

A

Thiamide that blocks Thyroid Peroxidase

27
Q

Propylthiouracil is what?

A

Thiamide that blocks Thyroid Peroxidase and Deiodinase 1

28
Q

Which Thyroid analog has a longer half life?

A

Levothyroxine

29
Q

SE of Thyroid Analogs?

A

Hyperthyroidism symptoms
Afib
Bone loss

30
Q

SE of Methimazole?

A

Embryopathy if pregnant

31
Q

SE of propylthiuracil

A

LIVER TOX

32
Q

Which Thiamide has a longer duration of action?

A

Methimazole

33
Q

How long until steady state of thyroxine?

A

6-8wks

34
Q

How long for full effect of Ptopylthiouracil?

A

2 wks

35
Q

First line treatment for Graves’?

A

Methimazole

36
Q

Radioactive 131-I used for?

A

Destruction of thyroid

37
Q

Radioactive 123-I used for?

A

Thyroid Scan

38
Q

Iodine used for?

A

Thyroid Storm TX

Prep for thyroidectomy

39
Q

SE of Iodine administration

A

Allergic
Sore Gums and Teeth
Excessive Salivation

40
Q

Why would you give Iodine for Thyroid Storm or prep for thyroidectomy?

A

High levels of Iodine inhibit all aspects of I- metabolism

Endocrine Pharmacology (5 decks)

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