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Endocrine Pharmacology > Wk (Deliver + Male) > Flashcards

Wk (Deliver + Male) Flashcards

1
Q

Methyl Testosterone is what?

A

Oral T analog

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2
Q

Methyl Testosterone specific SE?

A

Hepatotoxicity

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3
Q

Oxandrolone is what?

A

Oral DHT analog

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4
Q

Oxandrolone use?

A

Anabolic steroid

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5
Q

Male SE of synthetic Androgens?

A

Gynecomastia
Low Sperm
Baldness

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6
Q

Female SE of synthetic Androgens?

A

Short lighter menses
Clitorus enlargment
Increased body hair

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7
Q

Cyproterone Acetate is what?

A

Androgen R antagonist

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8
Q

Flutamide is what?

A

Pure non-steroidal Androgen R antagonist

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9
Q

Bicalutamide is what?

A

Pure non-steroidal Androgen R antagonist

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10
Q

Nilutamide is what?

A

Pure non-steroidal Androgen R antagonist

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11
Q

Cyproterone Acetate Use?

A

Decreases male libido

Hirsutism in women

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12
Q

Pure non-steroidal Androgen R antagonist uses?

A

Advanced Prostate Cancer

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13
Q

SE of Pure non-steroidal Androgen R antagonists?

A

Gynecomastia

Hepatotoxicity

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14
Q

Gonadorelin is what?

A

GnRH agonist

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15
Q

Gonadorelin is administered how?

A

IV

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16
Q

Gonadorelin is used for what? How is it administered?

A

Pulsatile = Improved sperm count

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17
Q

Leuprolide is what?

A

GnRH R Agonist

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18
Q

Leuprolide is used or what? How is it administered?

A

Non-pulsatile for Medical castration

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19
Q

Degarelix is what?

A

GnRH Antagonist

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20
Q

Ganirelix is what?

A

GnRH Antagonist

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21
Q

Cetrorelix is what?

A

GnRH Antagonist

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22
Q

Which GnRH antagonist is used for PBH or Male chemical castration?

A

Degarelix

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23
Q

Which GnRH antagonist(s) are used for Ovulation stimulation?

A

Ganirelix

Cetrorelix

24
Q

Finasteride is what?

A

5-a-reductase inhibitor

25
Q

Dutasteride is what?

A

5-a-reductase inhibitor

26
Q

5-a-reductase inhibitors are used for what?

A

Male pattern baldness

BPH

27
Q

What drug classes are used for chemical castration in males?

A 
Androgen R antagonists
GnRH agonists (Non-pulsatile)
GnRH antagonists (Non-pulsatile)
28
Q

Sildenafil is what?

A

PD5 inhibitor

29
Q

Sildenafil is used for?

30
Q

What should Sildenafil never be given with?

A

Nitrates

a-blockers

31
Q

Pitocin is what?

A

Synthetic Oxytocin

32
Q

Oxytocin receptor signals via what?

A

Gq GPCR –> IP3

33
Q

Pitocin Use?

A

Stimulate uterine contractions
Decreases post-partum bleeding
Milk Let down

34
Q

When don’t you use Pitocin?

A

For Abortion
If head to big/pelivs to small
If hypertonic contractions

35
Q

PGE vs. PGF in labor?

A

PGE

  • softens cervix
  • Stimulates uterine contractions
  • Gs signalling

PGF

  • Stimulates uterine contractions
  • Gq signalling
36
Q

Dinoprostone is what?

A

Natural PGE

37
Q

Misoprostol is what?

A

Synthetic PGE

38
Q

Carboprost is what?

A

Synthetic PGF2

39
Q

Which PG can be used to treat hyatidiform mole formation?

A

Dinoprostone

40
Q

Which PG can be used with Mifepristone as an abortifacient?

A

Misoprostol

41
Q

Which PG is Injected IM to to induce labor at ANY TIME DURING PREGNANCY?

A

Carboprost

42
Q

SE of PGs?

43
Q

Erogts MOA?

A

Toxin that stimulate SM contraction via a, DA, and 5HT Rs

44
Q

Ergonovine is used for?

A

Post-partum bleeding

45
Q

Ergotamine is used for?

46
Q

Terbutaline is what?

A

B2 agonist

47
Q

Terbutaline acts via what signalling?

A

B2 –> Gs –> cAMP –> PKA –> Decreased MLCK –> SM relaxation

48
Q

Terbutaline is used for what?

A

Reduce contractions

49
Q

Terbutaline SE?

A

Tachy –> MI
Pulm edema
Hyperglycemia

50
Q

Magnesium Sulfate MOA?

A

Binds and blocks L-Ca Channels –> SM relaxation

51
Q

Magnesium Sulfate Use?

A

Prevent seizures during eclampsia

52
Q

Atosiban is what?

A

Oxytocin R antagonist

53
Q

Atosiban use?

A

Delay labor

54
Q

Atosiban good and bad?

A 
Good = less SE than terbutaline
Bad = Higher infant mrtality
55
Q

Indomethacin use?

A

Inhibits PG stimulation of contractions

Endocrine Pharmacology (5 decks)

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