wk4: AED - Allergy [DG] Flashcards
What is the main cause of allergic conjunctiva presentations?
Contact lens wear
In regards to type 1 immune-mediated inflammation:
- when does it occur?
- is it an immediate or delayed response?
- occurs on second or later exposures (after primary exposure)
- immediate
In regards to type 4 immune-mediated inflammation:
- when does it occur?
- is it an immediate or delayed response?
- occurs on second or later exposures
- delayed
In regards to non-immune-mediated inflammation:
- what would cause this?
- when does it occur?
- is it immediate or delayed?
Direct injury/pharm effect (i.e. cell damage)
First exposure
Can be either immediate or delayed
In regards to type 1 immune-mediated inflammation:
- What cells and mediators are involved? (3)
- is it mainly cell or chemical mediators driving the response?
Mast cells
Eosinophils
Histamine
Response is mainly chemical mediators released from mast cells
In regards to type 4 immune-mediated inflammation:
- what cells and/or mediators are involved? (3)
- is the response mainly driven by cellular or chemical mediators?
Mainly cell mediators
Lymphocytes, Macrophages, Others
In regards to non-immune mediated inflammation:
- what cells and/or mediators are involved? (2)
- is the response driven by mainly cell or chemical mediators?
Chemical mediators from tissue and cells (usually neutrophil/macrophage)
In regards to type 1 immune-mediated inflammation:
- what kind of stimuli are responsible? (4)
usually pollen, dust mites, soft CLs, very rarely drugs
In regards to type 4 immune-mediated inflammation:
- what kind of stimuli are responsible? (4)
cosmesis, drugs, other biological FBs, ‘autoantigens’
In regards to non-immune-mediated inflammation:
- what kind of stimuli are responsible? (2)
drugs, chemicals
In regards to type 1 immune-mediated inflammation:
- how can this present in the eyelids? (1)
papillae
In regards to type 4 immune-mediated inflammation:
- how can this present in the eyelids? (3)
papillae, follicles, phlyctenules
In regards to non-immune mediated inflammation:
- how can this present in the eyelids? (1)
papillae
Name 4 kinds of allergic conjunctivitis
seasonal/perennial
vernal keratoconjunctivitis (VKC)
atopic keratoconjunctivitis
giant papillary conjunctivitis (GPC)
Which of the 4 kinds of allergic conjunctivitis are sight threatening? (2)
VKC and atopic
Which of the 4 kinds of allergic conjunctivitis are about px comfort?
seasonal/perennial conjunctivitis
Which of the 4 kinds of allergic conjunctivitis are associated with soft CLs?
GPC
Seasonal/Perennial conjunctivitis:
- how common?
- when might symptoms persist all year?
common
if px allergic to perennial allergen
Seasonal/Perennial conjunctivitis:
- what type of hypersensitivity? What mediates it?
- what proportion of population affected?
pure type 1 hypersensitivity (IgE mediated)
affects 5-20% of population, 80% under 30yrs
Seasonal/Perennial conjunctivitis:
- list its clinical features (7)
usually bilateral conj papillae hyperaemia (injection) oedema (chemosis) lids may also be oedematous serous + mucus discharge cornea unaffected
List the symptoms of seasonal/perennial conjunctivitis (3)
itchy eyes (hallmark)
watery eyes
associated sneezing etc.
What does the mast cell do in terms of the inflammatory response?
doesn’t do much other than alerting other cells to cause inflammation
What mediators and factors are released by mast cells? (6ish)
Histamines, Leukotrienes, Chemokines, LTB4, Proinflammatory cytokines, IL-4, IL-5, Tryptase
What cell and mediator is responsible for activating mast cells?
IgE from B cells