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HEMA > WK 8: Lab evaluation of 2nd Hemostasis > Flashcards

WK 8: Lab evaluation of 2nd Hemostasis Flashcards

1
Q

Specimen of choice for secondary hemostasis

A

Anticoagulated whole blood

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2
Q

Anticoagulant used:

A

Sodium citrate (3.2%)

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3
Q

(True or False)

Blood:Citrate ration is 1:9

A

(False)

9:1

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4
Q

This drug suppresses the platelet function

A

Aspirin

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5
Q

This drug reduces activities of Factor II, VII, IX, X

A

Coumadin (Warfarin)

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6
Q

(True or False)

Remove tourniquet within 1 minute of application

A

True

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7
Q

(True or False)

PTT is stored at 18-24C and processed within 24 hours

A

(False)
PPT = 4 hours
PT = 24 hours

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8
Q

Plasma stored at -20C should be processed within how many weeks?

A

2-4 weeks

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9
Q

Frozen samples thawed at 37C should be tested within how many hours?

A

1 hour

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10
Q

If the centrifugation is <10 minutes, what component may be produced?

A

Platelet rich plasma

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11
Q

(True or False)

When the hematocrit level is <55%, anticoagulant reduction must be done

A

(False)

>55%

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12
Q

This test is for Extrinsic pathway deficiencies

A

PT

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13
Q

Reagent used in Prothrombin time

A

Thromboplastin

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14
Q

The buffer used in PT

A

Calcium chloride

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15
Q

It indicates the purity of the reagent

A

ISI (Internationat sensitivity index)

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16
Q

Test that induces clot plasma formation without added thromboplastin

A

APTT

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17
Q

(True or False)

PT is for Intrinsic factor deficiencies

A

(False)
PT = Extrinsic
APTT = Intrinsic

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18
Q

This test is for monitoring heparin therapy

A

APTT

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19
Q

This test is for monitoring warfarin therapy

A

PT

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20
Q

Reagent used in APTT

A

Partial thromboplastin

21
Q

3 clotting factors that can activate clot formation in vitro thru intrinsic pathway

A

Factor XIIa
HMWK
Pre-K

22
Q

Normal range for APTT

A

25-40 seconds

23
Q

Therapeutic range for APTT

A

60-100 seconds

24
Q

Produces clot plasma formation after the addition of thrombin in the presence of calcium

A

Thrombin clotting time (TCT)

25
Q

2 heparin-like substances

A

Fibrin degradation products

Plasma proteins

26
Q

It is a quantitative/qualitative test for fibrinogen

A

Thrombin clotting time (TCT)

27
Q

Reagent used in TCT

A

Thrombin

28
Q

Thrombin cleaves _____ & ______

A

fibrinopeptides A & B

29
Q

Normal range for PT

A

10-14 seconds

30
Q

Normal range for TCT

A

15-20

31
Q

(True or False)

Dysfibrinogenemia is when you have sufficient fibrinogen but is dysfunctional

A

True

32
Q

(True or False)

Hypofibrinogenemia means you have high values of fibrinogen

A

(False)

Low

33
Q

This test converts fibrinogen to fibrin with the use of thrombin-like enzyme

A

Reptilase time

34
Q

This test is a modification of TCT but uses a different reagent

A

Reptilase time

35
Q

Thrombin-like enzyme used in Reptilase time came from the venom of what reptile?

A

Bothrops atrox

36
Q

It is also known as Stypven time

A

Russel Viper Venom test (RVVT)

37
Q

This test is an alternative for PT

A

RVVT

38
Q

Reagent used in RVVT came from the venom of what reptile?

A

Daboia russelii

39
Q

This test is used to detect the reason for the prolonged clotting time

A

Mixing studies

40
Q

(True or False)

When the prolonged clotting time is corrected, this is due to Factor inhibitor

A

(False)
Corrected = Factor deficiency
Not corrected = Factor inhibitor

41
Q

This test is a quantitative test for fibrinogen

A

Fibrinogen assay

42
Q

Buffer used in Fibrinogen assay

A

Owren buffer

43
Q

Prolonged PT, PTT

Normal TCT

A

Factor VII deficiency

44
Q

Normal PT PTT, Fibrinogen level

A

Factor XIII deficiency

45
Q

Assay used to measure the release of ammonia during an in vitro transglutaminase reaction

A

Factor XIII assay

46
Q

It is a fibrin degradation product

A

D-dimer

47
Q

In D-dimer immunoassay, the latex particles are coated with ________ antibodies with patient’s plasma D-dimer

A

Monoclonal anti-D dimer

48
Q

The endpoint reaction of this test yields a color whose intensity id directly proportional to the activity of serine protease

A

Chromogenic assay

49
Q

This test is a Factor XIII screening test

A

Urea Solubility test

HEMA (3 decks)

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