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HEMA > WK 10: Disorders of 2nd Hemostasis > Flashcards

WK 10: Disorders of 2nd Hemostasis Flashcards

1
Q

A quantitative deficiency that is caused by lack of synthesis by the liver

A

Afibrinogenemia

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2
Q

The most common treatment for Afibrinogenemia

A

Replacement therapy

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3
Q

A qualitative abnormality in the structure and function of fibrinogen molecule

A

Dysfibrinogenemia

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4
Q

(True or False)

A deficient clot in Factor XIII deficiency will not be dissolved in 5M urea after 24 hrs

A

(False)
Normal clot will not dissolve
Deficient clot will dissolve

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5
Q

It refers to a deposition of large amounts of fibrin throughout the microcirculation

A

DIC

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6
Q

(True or False)

Platelet count in DIC is decreased

A

True

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7
Q

(True or False)

APTT, PT, TT in DIC is normal

A

(False)

Prolonged

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8
Q

This is symptomatically similar to DIC that results from increased plasmin

A

Primary Fibrinolysis

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9
Q

(True or False)

Factor VIII has the shortest half-life

A

(False)

VII

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10
Q

This disease is associated with coagulation disorders

A

Liver disease

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11
Q

It also means decreased fibrinogen production

A

Hypofibrinogenemia

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12
Q

Therapeutic Heparin Administration is commonly used in ____ & _____ patients

A

Post-surgical

Cardiac

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13
Q

This test can be done with Reptilase time

A

Therapeutic Heparin Administration

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14
Q

What defect is associated with:
Prolonged TT
Normal RT

A

Heparin

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15
Q

What defect is associated with:
Prolonged TT
Moderate RT

A

Fibrin degradation product

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16
Q

Dysfunction of Antihemophilic factor (VIII)

A

Hemophilia A

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17
Q

What is the inheritance pattern for Hemophilia A

A

Sex-linked

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18
Q

An antigen that neutralizes anti-VIII:C antibodies

A

Cross-reacting material (CRM)

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19
Q

It is also known as Christmas disease

A

Hemophilia B

20
Q

Hemophilia B is a inherited deficiency in factor ____

A

IX

21
Q

Why is FFP replacement therapy the chosen treatment for Hemophilia B?

A

FFP contains active factor IX

22
Q

(True or False)

The half life of factor IX is 12 hours

A

(False)
IX = 24 hours
VIII = 12 hours

23
Q

It is the most common “classic” form of vWD

A

Type I

24
Q

In this type of vWD, ristocetin-induced activity is decreased

A

Type IIa

25
Q

What are absent in type IIa vWD

A

Platelet

Plasma

26
Q

In this type of vWB, ristocetin-induced activity is normal/increased

A

Type IIb

27
Q

Which type of vWD is the most rare and severe?

A

Type III

28
Q

Activating factor used for Factor XII, HMWK, Pre-K deficiencies

A

Kaolin

29
Q

Deficiency that is caused by quantitative/qualitative abnormality of factor X molecule

A

Factor X deficiency

30
Q

This is an extremely rare deficiency

A

Prothrombin deficiency (Factor II)

31
Q

Prolonged PT and APTT in Prothrombin deficiency can be corrected in substitution testing by ________

A

Fresh normal plasma

32
Q

(True or False)

Acquired VIII:R (vWD) develop in healthy women after child birth

A

(False)

Inhibitors to VIII:C

33
Q

It occurs following drug therapy of patients with tuberculosis

A

Acquired inhibition of Factor XIII

34
Q

Occurs on persons with amyloidosis

A

Factor X deficiency

35
Q

It develops in significant number of patients taking phenothiazine

A

Lupus-like anticoagulant

36
Q

Inhibitors commonly used in patients with Lupus-like anticoagulant

A

IgG

IgM

37
Q

(True or False)

Patients with Lupus-like anticoagulant occasionally have a sever thrombocytopenia

A

(False)

Mild thrombocytopenia

38
Q

Due to impaired synthesis of factors II, VII, IX, X, protein C & S

A

Vitamin K deficiency

39
Q

It is a fast and potent form of anticoagulation

A

Exogenous heparin therapy

40
Q

Heparin is commonly used to treat _______

A

Thrombosis

41
Q

If PT, APTT, TT is greatly prolonged, what is most probably considered present?

A

Heparin

42
Q

What is added to the plasma sample if there is an unconfirmed presence of heparin?

A

Protamine sulfate

43
Q

The most common hereditary bleeding disorder

A

von Willebrand disease

44
Q

Generally affect only one hemostatic component

A

Inherited disorders

45
Q

Involve multiple hemostatic components or pathways

A

Acquired disorders

46
Q

What is the carrier protein for factor VIII:C in secondary hemostasis

A

vWF

HEMA (3 decks)

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