WK 10: Disorders of 2nd Hemostasis

Question 1

A quantitative deficiency that is caused by lack of synthesis by the liver

Answer 1

Afibrinogenemia

Question 2

The most common treatment for Afibrinogenemia

Answer 2

Replacement therapy

Question 3

A qualitative abnormality in the structure and function of fibrinogen molecule

Answer 3

Dysfibrinogenemia

Question 4

(True or False)

A deficient clot in Factor XIII deficiency will not be dissolved in 5M urea after 24 hrs

Answer 4

(False)
Normal clot will not dissolve
Deficient clot will dissolve

Question 5

It refers to a deposition of large amounts of fibrin throughout the microcirculation

Answer 5

DIC

Question 6

(True or False)

Platelet count in DIC is decreased

Answer 6

True

Question 7

(True or False)

APTT, PT, TT in DIC is normal

Answer 7

(False)

Prolonged

Question 8

This is symptomatically similar to DIC that results from increased plasmin

Answer 8

Primary Fibrinolysis

Question 9

(True or False)

Factor VIII has the shortest half-life

Answer 9

(False)

VII

Question 10

This disease is associated with coagulation disorders

Answer 10

Liver disease

Question 11

It also means decreased fibrinogen production

Answer 11

Hypofibrinogenemia

Question 12

Therapeutic Heparin Administration is commonly used in ____ & _____ patients

Answer 12

Post-surgical

Cardiac

Question 13

This test can be done with Reptilase time

Answer 13

Therapeutic Heparin Administration

Question 14

What defect is associated with:
Prolonged TT
Normal RT

Answer 14

Heparin

Question 15

What defect is associated with:
Prolonged TT
Moderate RT

Answer 15

Fibrin degradation product

Question 16

Dysfunction of Antihemophilic factor (VIII)

Answer 16

Hemophilia A

Question 17

What is the inheritance pattern for Hemophilia A

Answer 17

Sex-linked

Question 18

An antigen that neutralizes anti-VIII:C antibodies

Answer 18

Cross-reacting material (CRM)

Question 19

It is also known as Christmas disease

Answer 19

Hemophilia B

Question 20

Hemophilia B is a inherited deficiency in factor ____

Answer 20

IX

Question 21

Why is FFP replacement therapy the chosen treatment for Hemophilia B?

Answer 21

FFP contains active factor IX

Question 22

(True or False)

The half life of factor IX is 12 hours

Answer 22

(False)
IX = 24 hours
VIII = 12 hours

Question 23

It is the most common “classic” form of vWD

Answer 23

Type I

Question 24

In this type of vWD, ristocetin-induced activity is decreased

Answer 24

Type IIa

Question 25

What are absent in type IIa vWD

Answer 25

Platelet | Plasma

Question 26

In this type of vWB, ristocetin-induced activity is normal/increased

Answer 26

Type IIb

Question 27

Which type of vWD is the most rare and severe?

Answer 27

Type III

Question 28

Activating factor used for Factor XII, HMWK, Pre-K deficiencies

Answer 28

Kaolin

Question 29

Deficiency that is caused by quantitative/qualitative abnormality of factor X molecule

Answer 29

Factor X deficiency

Question 30

This is an extremely rare deficiency

Answer 30

Prothrombin deficiency (Factor II)

Question 31

Prolonged PT and APTT in Prothrombin deficiency can be corrected in substitution testing by ________

Answer 31

Fresh normal plasma

Question 32

(True or False) | Acquired VIII:R (vWD) develop in healthy women after child birth

Answer 32

(False) | Inhibitors to VIII:C

Question 33

It occurs following drug therapy of patients with tuberculosis

Answer 33

Acquired inhibition of Factor XIII

Question 34

Occurs on persons with amyloidosis

Answer 34

Factor X deficiency

Question 35

It develops in significant number of patients taking phenothiazine

Answer 35

Lupus-like anticoagulant

Question 36

Inhibitors commonly used in patients with Lupus-like anticoagulant

Answer 36

IgG | IgM

Question 37

(True or False) | Patients with Lupus-like anticoagulant occasionally have a sever thrombocytopenia

Answer 37

(False) | Mild thrombocytopenia

Question 38

Due to impaired synthesis of factors II, VII, IX, X, protein C & S

Answer 38

Vitamin K deficiency

Question 39

It is a fast and potent form of anticoagulation

Answer 39

Exogenous heparin therapy

Question 40

Heparin is commonly used to treat _______

Answer 40

Thrombosis

Question 41

If PT, APTT, TT is greatly prolonged, what is most probably considered present?

Answer 41

Heparin

Question 42

What is added to the plasma sample if there is an unconfirmed presence of heparin?

Answer 42

Protamine sulfate

Question 43

The most common hereditary bleeding disorder

Answer 43

von Willebrand disease

Question 44

Generally affect only one hemostatic component

Answer 44

Inherited disorders

Question 45

Involve multiple hemostatic components or pathways

Answer 45

Acquired disorders

Question 46

What is the carrier protein for factor VIII:C in secondary hemostasis

Answer 46

vWF