wk 1 DRUGS

Question 1

spironolactone

Answer 1

aldosterone agonist

used as K sparing diuretic

Question 2

fludrocortisone

Answer 2

replacement therapy for Addison’s disease (adrenal hypo function) – decreased cortisol and aldosterone

Question 3

metyrapone

ketoclonazole

Answer 3

drugs used for Cushing’s to inhibit steroid synthesis

Question 4

pasireotide

cabergoline

Answer 4

drugs used for Cushing’s to inhibit ACTH release-

pas: SSTR5 agonist (somatostatin analogue)
caber: dopamine D2 agonist

Question 5

mifeprestone

Answer 5

used for Cushing’s
inhibit glucocorticoid receptor
also a progesterone receptor antagonist

Question 6

cabergoline

Answer 6

• treat high levels of prolactin

- Cushing’s - to inhibit ACTH release

Question 7

D2 agonists to treat high PL

Answer 7

cabergoline

bromocriptine

Question 8

liothyronine

Answer 8

treatment for Hashimotos
sodium salt of T3
effect lasts 8 days

Question 9

carbimazole and propylthiouracil

Answer 9

antithyroid drugs

Grave’s disease

Question 10

drug treatment for hypothyroidism, inc dose

Answer 10

levothyroxine

75-125 mcg per day