Wittig Flashcards
1
Q
Reactants and products
A
Aldehyde/ketone to alkenes
2
Q
Unstabilised ylides
A
No conjugated withdrawing group, needs nBuLi/LDA, reacts with aldehydes and ketones, forms Z product
3
Q
stabilised ylides
A
Has anion stabilising group, NaOEt/NaOH, aldehydes only, forms E product
4
Q
Ylide formation
A
PPh3 and alkyl bromide
5
Q
Unstabilised ylide mechanism
A
Ylide and C=O approach perpendicular, large substituents kept apart, forms Z product
6
Q
Stabilised ylide mechanism
A
Ylide and C=O perpendicular, large subs kept apar and electronegative groups repel, forms E product
