Amine Synthesis

Question 1

Amide approach

Answer 1

Amine + acid chloride gives amide then use lethal to reduce to secondary amine

Question 2

Imine approach

Answer 2

Reductive animation, amine + aldehydes/ketone gives imine then use NaB(CN)3H to reduce C=N and give amine

Question 3

Cyanide approach

Answer 3

Alkyl bromide + NaCN gives nitrile then reduces to amine using lithal

Question 4

Azide approach

Answer 4

Alkyl bromide + NaN3 gives R-N3 then reduces to amine using lithal, can only be used for primary amines