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Gastrointestinal > Whitt: Gi viruses > Flashcards

Whitt: Gi viruses Flashcards

1
Q

“most important agent of severe Diarrheal illness in infants and young children worldwide”

A

Rotovirus-(reoviridae)

followed by ETEC, UNKNOWN, Adenovirus

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2
Q

reoviridae stands for

A

respiratory
enteric
orphan

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3
Q

NON-ENVELOPED particles

2-3 concentric icosahedral capsids

A

rotavirus

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4
Q

rotavirus characters

A

non enveloped

2-3 concentric icosahedral capsids

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5
Q

rotavirus G

A

VP7-neutralization antigen

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6
Q

rotavirus P

A

VP4-neutralization antigen

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7
Q

rotavirus: only 4 G-P combos cause 90% of the Dz

* basis of the success of the vaccine

A

G1-P8
G2-P4
G3-P8
G4-P8

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8
Q

replication cycle of rotorviruses

A
  1. taken up by endocytosis (capsid prots are processed either in the gut or in the lysosome)-forms infectious subviral particle
  2. core enzymes-begin synthesizing mRNAs-asymettric only 10-12 +strands
  3. capped + strands to “assortment complexes
  4. negative strands made
  5. dsRNA genome complete
  6. lysis and release
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9
Q

asembly of rotoviruses occurs entirely within the

A

cytoplasm in cytoplasmic viroplasms (viral factory)

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10
Q

calciviridae

A

noroviruses

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11
Q

foodborne epidemic acute gastroenteritis in older children and adults

A

noroviruses (calciviridae)

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12
Q

non-enveloped, non-segmented

+ strand RNA virus

A

Norovirus

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13
Q

“hospitalized with D in first 2 years of life”

A

rotovirus

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14
Q

community based outbreaks in older school aged children and adults-non bacterial D

A

norovirus

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15
Q

winter vomiting disease

A

norovirus

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16
Q

transmission of roto-noro viruses

A

fecal oral mainly

*extremely stable in the environment

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17
Q

this bug outbreaks are located to a single source
1. contaminated food
(icing, oysters, salads)
2. cruise ships and nursing homes

A

norovirus

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18
Q

this virus can be airborne

A

norovirus

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19
Q

clinical course for noro and rotoviruses

A

N/V/D/F

leading to dehydration

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20
Q

noro and rotoviruses initiallty infect +_+__

A

tips of villi in the small bowel

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21
Q

NORO and ROTO role in Diarrheal disease

A

do not activate cAMP-unlike cholera toxin

  • they do cause loss of villious cells-> FUNCTIONAL ALTERATIONS IN SMALL/LARGE intestines
  • >
22
Q

most important factor for protection agfaisnt rreinfection by both rota and noroviruses is….

A

local (intestinal) immunity

23
Q

antibodies to rotaviruses

A

obtained early in life

24
Q

ab’s to noroviruses

A

acquired gradually in childhood and icnrease steadily over life time

25
Q

two vaccines for rotoviruses

A

rotateq

rotarix

26
Q

rotateq

A
  • Approved for sale in U.S. by FDA in February, 2006
  • Pentavalent bovine-human reassortant viruses (serotypes G1-G4 and P8) -Live, attenuated vaccine given orally at 2, 4, and 6 months
27
Q

rotarix

A
  • Human-derived monovalent (G1, P8), live, attenuated vaccine
  • Administered orally in two doses starting at 6-weeks of age
28
Q

norovirus vaccines

A

none

29
Q

non-enveloped, icosahedra;, single stranded, +sense RNA

STAR LIKE APPEANCE

A

Astroviruses

30
Q

after reoviruses-second most common cause of childhood D in children <1 year old

A

Astroviruses

31
Q

whatr % of 5-10 year olds have Ab’s to astroviriuses

A

80%

32
Q

spread by astroviruses

A

oral-fecal route

33
Q

peak incidence of astrovrisues

A

winter-self limiting

34
Q

vaccine for astroviruses

A

not available

35
Q

picoviridae

A

enteroviruses

36
Q

small icosahedral nonenveloped + sense RNA viruses

A

enteroviruses

37
Q

pico=

A

small-RNA virus

38
Q

name the enteroviruses

picornoviridae

A

polio
enterovirus
cocksackie A and B
echoviruses

39
Q

causes flaccid paralysis

A

polioviruses

40
Q

ECHO virus stands for

A

enteric, cytotoxic, human orphan

41
Q

also an enterovirus-like virus

A

hepatitis A

42
Q

what differentiates enteroviruses from rhinoviruses

A

a. acid stability
b. replicaiton at 37 degrees
* enteroviruses can do both of these thangs

43
Q

spread of enteroviruses

A

fecal-oral route

humans only reservoir

44
Q

initially replicate in the lymph tissue of URT and Gut

A

enteroviruses

45
Q

enteroviruses can be cultured from

A

throat swabs

46
Q

viremia with enteroviruses causes

A

Spinal cord and brain infectin
myocardium
skin
meninges

47
Q

how quick is enteroviruses in stool and throat

A

10 days in stool and throat

blood in 9

csf in 14

48
Q

vaccines for enteroviruses

A

polio only

49
Q

adenoviridae

A

adenovirus

50
Q

large, non enveloped, linear dsDNA

A

adenovirus

51
Q

two ADENO stereotypes associated with gastroenteritis

A

40 and 41

Gastrointestinal (9 decks)

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