White Blood Cells

Question 1

What are normal white blood cells?
Where are they found?
What are they produced from?

Answer 1

Mature cells

Circulate in the blood

Produced from immature precursor cells in the bone marrow derived from stem cells

Question 2

The rate of WBC production controlled by?

Answer 2

Hormonal control of G-CSF (granulocyte colony stimulating factor)

Question 3

What is the most numerous white cell?

Answer 3

Neutrophils

Question 4

What are neutrophils lifespans?

Answer 4

10 hours

Question 5

What is their function and what do they release?

Answer 5

Phagocytose & kill bacteria
Release chemotaxins (signal more white blood cells to come to site) and cytokines - important in inflammatory response

Question 6

What are B and T lymphocytes vital for and general roles?

Answer 6

Vital to immunity

Some generate antibodies against specific foreign antigens e.g bacteria & viruses

Others are immunological memory - which generates immunity and allows vaccination

Question 7

B lymphocytes 
Where are they made?
Stored?
Differentiate into?
Function?

Answer 7

named after Bone marrow, made in bone marrow - stored in secondary lymphoid organs, differentiate into plasma cells and produced immunoglobulins when stimulated by exposure to foreign antigen

Question 8

T lymphocytes
Where are they made?
Where do they mature?
Functions?

Answer 8

Made in bone marrow - MATURE in thymus, some are helper cells (CD4, help B cells in antibody generation, responsible for cellular or cell mediated immunity), some are cytotoxic cells (CD8)