What responds well in haemochromatosis to venesection Flashcards
what responds well in haemochromatosis, what does not
skin, fatigue, LFTs, hepatomeg respond well
diabetes, heart may improve, hypogonadism
fibrosis, cirrhosis, arthropathy do not improve
aim for ferritin in haemochrom
50-100
who to not treat in haemochromatosis
do not treat asymptomatic people with ferritin under 500 and sats under 60
AVOID UNCOOKED SEAFOOD AS AT RISK VIBRIO
acanthosis nigricans associated with which cancer
gastric
Mother TNF during pregnancy- suggest hold off for how long with live vaccines
6 months
safe to breast feed on them- no immunosup
what types of skin cancers are assoc with TNF agents and AZA
TNF- melanoma
AZA- non melanoma, espec SCC
Iron, calcium, vitamin C and folate are absorbed where
proximal jejunum
gastrin binds what receptor
cckB
IF you are HBcAb positive and that is it, what are the possibilities?
remote resolved infection (most common)
recovering from acute infection
false positive
Occult HBV and if do PCR will be positive
Why is FIT better than FOBT
Fewer false positives
doesnt find blood from upper GIT so specific for lower
dont have to have dietary restriction prior
binds to GLOBIN portion
what BMI gets you considered for bariatric surgery?
35 and over with comorbidities
40 and over otherwise
what is the major macronutrient associated with bariatric surgery deficiency
protein
If resistance to thiamine deficiency (ie after bariatric surgery when present with neuropsych symptoms, heart failure, consitpation or megacolon)
consider small bowel overgrowth!
Predict response hep C to treatment with ribavirin and PEG interferon
non genotype 1 low HCV RNA absence fibrosis pr cirrhosis duration of therapy for genotype 1 age 40 or below adherence no steatosis on liver biopsy
Treatment of lymphocytic colitis
start with stop alcohol caffiene and dairy
stop aspirin, ranitadine, acarbose, NSAIDs
anti diarrhoeals
budesonide
some need methotreate , sulfasal, aza
