Extras Flashcards

1
Q

Test for bile acid malabsorption

A

SeHCAT test
done 7 days apart to see how much of the nuclear stuff you have retained

crohns
cholecystectomy
celiac disease
small intestinal bacterial overgrowth

treat with bile acid sequestrants like cholestyramine

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2
Q

Features of PBC

A
asymptomatic increase ALP
middle aged women
xanthelasmas, xanthomatas
increase pigmentation over pressure points
fatigue pruritis
cholestatic jaundice

20 x increased risk gallbladder cancer
malabsorption–>osteomalacia and coagulopathy
sicca in 70%
portal hypertension

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3
Q

gastroparesis diagnosis

A

suggestive to have food undigested in stomach after ovenight fast

but gold standard is 99mtech labelled egg white meal gastric emptying scan

but opioids and functional dyspepsia false pos

prokinetics but remember tardive dyskinesia if over 3 months

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4
Q

Diabetics with gastroparesis what to do

A

amylin analogues- pramlintide and GLP1 agonists (exentaide) reduce gastric emptying so could stop

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5
Q

metoclopramide MOA

A

antag D2
antag 5HT3
Ag 5HT4

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6
Q

do cyclo and tac cause gastroparesis

A

cyclo not tac

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7
Q

cut off for liver tx meld

A

If meld under 15 then risks of transplants outweight the benefits

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8
Q

After bariatric surgery can get what type ofcomplication

A

NAFLD faler

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9
Q

when do you do capsule endoscopy

A

very clear that only indicated if replace iron but then FAIL and have RECURRENT iron der

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10
Q

does normal CRP rule out crohns

A

no

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11
Q

role for ERCP for cholangio screen in PSC

A

no

but if jump in LFTs then do

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12
Q

what gets lost first when clearing hep B

A

eAg before aAg

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13
Q

suspect IBD in young woman, what to do

A

either low fodmap

or faecal calprotectin

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14
Q

NASH score how useful

A

to predict who will go on to get cirrhosis

higher if DM2 or IGT

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15
Q

most important EUC abnormality in hepatic enceph

A

hypokalaemia

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16
Q

what is microscopic colitis

A

profuse watery diarrhoea in mid to older person
biopsy increased both in the surface epithelium (“intraepithelial lymphocytes”) and in the lamina propria
benign
budesonide

17
Q

who with haemochromatosis is at risk cirrhosis

A

ferritin over 1000
age over 50
normal ALT

18
Q

treat ileal resection diarrhoea

A

cholestyramine

19
Q

most well studied RF for IBS

A

infectious diarrhea in 1/3

20
Q

prominent gastric folds with a single ulcer, think

A

zollinger ellison

21
Q

how diagnose zollinger ellison

A

fasting serum gastrin over 10 x ULN and pH under 4 gastric
must check gastric pH because high levels also in atrophic gastritis, renal failure, vagotomy - but ehre pH will be over 4’

if cannot make it, then secretin stimulation test will do it (should inhibit G cells but tumour cells are stimulated)

PPI false positive

22
Q

when is serum chromogrannin A useful

A

increase in patients with gastrinomas even without liver mets
normal levels if secondary to atrophic gastritis

23
Q

treat gastrinoma

A

mediacl therpay with high dose PPI if with MEN 1
sporadic- medical and resect

sometimes may respond to somatostatin analogue

24
Q

what are the two phenotypes of H pylori infectin

A

antral predomonant gastritis–>predispose duodenal ulcers

pangastritis –>multifocal gastric atrophy and intestinal metaplasia–>carcinoma and gastric ulcers

25
Q

different trends with H pylori atrophic gastritis and autoimmune

A

in H pylori, multifocal atrophy
In autoimmune, mostly fundus (top bit)

BOTH predispose to gastric cancer

26
Q

mesalazine or sulfasal for pancreatitis risk?

A

mesalazine

but better for fertility!

27
Q

gastric cancer classic histo

A

signet ring cells

gastric cancer asssoc with blood group A

28
Q

carcinoid diagnossi

A

24 hour urinary 5-HIAA (though not useful in gastroduodenal or bronchial carcinoid where need imaging)

29
Q

manage carinoid

A

octreotide- reuces tumour production of 5-HIAA
loperamide
hep resection if appropriate
octreotide pre op to reduce risk carcinoid crisis

30
Q

scleroderma vs achalasia on manometry

A

reduced pressure LES scleroderma

increased pressure LES achalasia