GI hormones

Question 1

Gastrin

-Produced by

Answer 1

G cells in antrum of stomach

Question 2

Gastrin

• stimulated by
• inhibited by

Answer 2

Distended stomach
Vagus nerves mediated by gastrin releasing peptide
Luminal peptides

Inhibited by low antral pH
Inhibited by somatostatin

Question 3

Gastrin

-action

Answer 3

Increase HCL
Increase pepsinogen and IF secretion
Increase gastric motility
Increase parietal cell maturation

Question 4

CCK

-produced by

Answer 4

I cells in upper small intestine

Question 5

CCK

-stimulated by

Answer 5

partly digested proteins and triglycerides

Question 6

CCK

-effect

Answer 6

Increases secretion of bicarbonate rich fluid from pancreas
Contract gallbladder
Relax sphincter of oddi
Reduce gastric emptying
induce satiety
trophic effect on pancreatic acinar cells

Question 7

Secretin

-produced by

Answer 7

S cells in upper small intestine

Question 8

Secretin

-stimulated by

Answer 8

Acidic chyme and fatty acids

Question 9

Secretin

-effects

Answer 9

Increase bicarb rich secretions from pancreas and hepatic duct cells
Decrease gastric acid secretion
Trophoblastic effect on pancreatic acinar cells

Question 10

VIP

-secreted from

Answer 10

small intestine and pancreas

Question 11

VIP

-stimulus

Answer 11

neutral

Question 12

VIP

-action

Answer 12

stimulates secretion by pancreas and intestines

inhibits acid secretion

Question 13

Somatostatin

-source

Answer 13

D cells in the pancreas and stomach

Question 14

Somatostatin

-stimulus

Answer 14

Fat, bile salts, glucose in the intestinal lumen

Question 15

Somatostatin

-actions

Answer 15

Decrease acid and pepsin secretion
Decrease pancreatic enzyme secretion
Decrease insulin and glucagon secretion
Inhibit trophic effects of gastrin
Stimulate gastric mucin production