WH Intro Flashcards
What components are necessary to cause differentiation of female sex system?
- genetics: 46XX
- proteins
- hormones
- ovaries
What is Turner Syndrome?
- 45 XO
- streak ovaries w/ few ovarian follicles
- gonadal dysgenesis
- no gonadal sex hormone production
What are some physical characteristics seen in Turner Syndrome?
- short stature
- webbed neck
- poor breast development
- wide carrying of the arms
- renal anomalies and liver dysfunction
- ocular and auditory deficiencies
Treatment of Turner Syndrome
- growth hormone
- estrogen
- progestins
What conditions might be caused by excess androgens?
- hirsutism
- virilization (masculinization of reproductive structures)
- polycystic ovary syndrome (PCOS)
- hormone secreting turmors
- adrenal: Cushings, congenital adrenal hyperplasia
What happens with an imperforate hymen?
- pt will menstruate but blood has nowhere to go
- present with pain and bloating
- easily fixed
What happens with transverse vaginal septum?
- no opening between upper and lower vagina
- amenorrhea, pelvic pain
What happens with agenesis of the lower vagina?
- no fusion of the upper with lower vagina
- must be reconstructed surgically
What happens with a bicornate uterus?
- poor fusion of Mullerian ducts = divided uterus
- would be difficult to maintain a pregnancy b/c of space restrictions (will cause an abortion)
When the hypothalamic-pituitary-ovarian axis gets activated at puberty, what happens physiologically?
- GnRH is released
- produce sex steroids from ovary
- secondary sexual maturation (breasts, female pattern hair growth)
- ovulation/menstruation
Hypothalamic-Pituitary-Ovarian Axis: What is released from each part?
- hypothalamus: gonadotropin releasing hormone
- pituitary: gonadotropins (LH and FSH)
- ovaries: sex steroid hormones (estrogen, progesterone)
During the reproductive cycle, when is estrogen at its highest level? When is progesterone at its highest level?
- estrogen peaks right before ovulation then drops dramatically when egg released
- progesterone peaks in days to week after egg is released (luteal phase)
What happens during the follicular phase of the reproductive cycle?
- onset of menses to the day of the LH surge
- 14 days
- FSH increases: follicular growth of oocytes
- estradiol: maintains endometrium
What happens during ovulation?
- estradiol feedback causes LH surge, which triggers ovulation
- oocyte released from ovary
- follicle becomes corpus luteum
What happens during the luteal phase of the reproductive cycle?
- predominance of progesterone
- suppress LH and FSH
- w/ fertilization: implanted zygote
- no fertilization: corpus luteum involutes and withdrawal of progesterone results in FSH release and start of new cycle