Weir's Targeted Therapies

Question 1

Most peripheral lung malignancies are what kind of tumor?

Answer 1

Adenocarcinomas

Question 2

Activating mutation seen in Lung cancer (especially non-smokers with adenocarcinomas)?

Answer 2

EGFR kinase

Question 3

Treatment against EGFR kinase activation

Answer 3

Erlotinib

Question 4

Mutation seen in Lung Cancers, especially never smokers, East Asians, and females?

Answer 4

EML4-ALK

Question 5

Treatment for EML4-ALK mutation?

Answer 5

Crizotinib

Question 6

Mutation normally seen in Head and Neck cancer (Tonsillar)?

Answer 6

EGFR receptor

Question 7

Treatment for EGFR mutation in Head and Neck Cancer?

Answer 7

Cetuximab

Question 8

Most common brain neoplasms?

Answer 8

Gliomas

Question 9

Where do gliomas come from?

Answer 9

The supporting framework of the neurons, the glial cells

Question 10

Grading of Gliomas/Glioblastomas?

Answer 10

Grade 1-2–> beningn (can still elicit symptoms/death)
Grade 3-4–> malignant
Grade 4–> Glioblastoma

Question 11

Mutation seen in Gliomas/Glioblastomas?

Answer 11

VEGF (the ligand, not receptor)

Question 12

Targeted therapy for Gliomas/Glioblastomas?

Answer 12

Bevacizumab

Question 13

How does Bevacizumab improve patient’s lives with Glioblastomas?

Answer 13

It doesn’t make you live longer, just shrinks the tumor removing pressure on various parts of the brain. This causes alleviation of symptoms (temporary)

Question 14

Targeted therapy for Progressive Renal Cancer?

Answer 14

Sunitinib

Question 15

Treatment for Hormone responsive Breast cancer?

Answer 15

Tamoxifen

Question 16

Target in hormone sensitive breast cancer?

Answer 16

Estrogen receptor

Question 17

mTOR inhibitor also used in treatment of breast cancer?

Answer 17

Everolimus

Question 18

Everolimus + Tamoxifen therapy?

Answer 18

Used in combination for breast cancer when hormone therapy alone has failed. Doubles time until progression in metastatic breast cancer

Question 19

Drug targeting HER-2 receptor?

Answer 19

Trastuzumab

Question 20

Trastuzumab indication?

Answer 20

HER-2 positive Breast cancer

Question 21

Drug targeting androgen receptors in Prostate cancer?

Answer 21

Enzalutamide

Question 22

What drives most Prostate cancer progression?

Answer 22

Androgens (Testosterone)

Question 23

Drug targeting BRAF mutations?

Answer 23

Vemurafenib

Question 24

Drug targeting the Hedgehog pathway?

Answer 24

Vismodegib

Question 25

Indication for Vismodegib?

Answer 25

locally advanced basal cell carcinomas

Question 26

Mutation seen in GI Stromal tumor?

Answer 26

cKIT mutation

Question 27

Drug targeting GI Stromal tumor?

Answer 27

Imatinib