Tavalin's bullshit Flashcards
Henderson-Hasselbalch equation
Therpeutic window is
Maximum tolerable concentration - minimum effective concentration
Advantages and disadvantages of oral administration
Advantages: safe, cheap
Disadvantages: Slow onset, patient noncompliance, low bioavailability (1st pass)
Factors affecting GI absoprtion of drugs
- Acidic environment of stomach cna breakdown drugs
- Gastric emptying time
- Intestinal motility and transit time
Volume distribution equation
Who does Tavalin remind you of?
Volume of extracellular fluid
13-16 L
Volume of plasma
~4 L
Volume of interstitial fluid
10-13 L
Volume of intracellular fluid
25-28 L
Total body water
40 L
Phase I metbaolic reactions take place in
Endoplasmic reticulum
Phase II metabolic reactions take place in
Cytosol
Phase I reaction types
- Oxidation
- Reduction
- Hydrolysis
Phase II reaction types
- Glucuronidation
- Acylation
- Sulfoxidation
- Glutathione conjugation
Energy source required for cytochrome P450 function
NADPH
Population distribution for genotypic polymorphisms
Renal clearance of 120 mL/min
Drug is filtered, but not secreted or reabsorbed
Renal clearance less than 120 mL/min
Drug shows net reabsorption
Renal clearance greater than 120 mL/min
Tubular secretion is contributing to elimination of the drug
Dosing rate equation
Dosing rate = CL x Css
Css = Steady-state concentration
Organ clearance equation
CL = Q[(CA - CV)/CA] = Q x E
Q = blood flow to organ
CA = arterial concentration
CV = venous concentration
E = extraction ratio
Elimination half-life equation
Ke = 0.7/t1/2
Ke = CL/Vd
Ke = elimination constant
Bioavailability and dosing equation
Css = (F x Dose)/(CL x T)
Css = Steady state concentration
F = bioavailability term
T = dosing interval
