Weilbaecher Alcohol Lecture Flashcards
1
Q
Drugs that inhibit ethanol metabolism: Enzyme they act upon and location
A
Fomepizole: Inhibits alcohol dehydrogenase in the cytosol
Aminotriazole: Inhibits catalase in the peroxisome
Antabuse/Disulfiram: Inhibits aldehyde dehydrogenase in the mitochondria
2
Q
Which TCA cycle enzymes are inhibited by excess ethanol metabolism?
A
Isocitrate dehydrogenase, a-ketoglutarate dehydrogenase,
3
Q
What is ethanol broken down into?
A
Acetate, which is activated to Acetyl-CoA
4
Q
What type of acidosis does ethanol cause?
A
Anion gap metabolic acidosis
5
Q
What two factors lead to acidosis?
A
Pyruvate being converted into lactic acid
Increased ketogenesis/acidic ketone bodies
