week4 Flashcards
Revise criteria used for virus classification
type and organisation of genome (DNA/RNA) - single or double stranded
viral replication strategy- reverse transcription?
stricture + size of the viron (envelope?)
host range
Revise replication cycle of herpes simplex
herpes: cell membrane is derived from a host lipid bilayer, fusion initiated between host and virus and caspid is injected into cytoplasm.
parental capsid docks onto a host nuclear pore complex (NPC)
viral genome then translocates through the nuclear pore into the nucleoplasm, where it is transcribed and replicated to propagate infection
Describe the replication cycle of rotavirus.
Revise replication cycle of HIV
describe the clinical features and structure of HIV
Human Immunodeficiency virus, inner cone shaped core with 2 strands of single RNA. surrounded by matrix protein and lipid membrane.- usual infection symptoms, weight loss can be noticeable.
describe the clinical features and structure of herpes simplex
herpes viruses, four layered structure: a core containing double-stranded DNA genome, icosapentahedral capsid, amorphous protein coat called the tegument, glycoprotein-bearing lipid bilayer envelope. Traditional sores apperance.
describe the clinical features and structure of hep A
HEP A- enteric picornavirus. genome single stranded RNA. naked, icosahaedral. Upper right quadrant pain, loss of appetite, dark urine,
describe the clinical features and structure of hep B
B Icosahedral nucleocapsid- circular dna partially double stranded. Symptoms same as hep A but also jaundice + hives
describe the clinical features and structure of hep C
C viruses, Enveloped Icosahedral nucleocapsid, Single stranded RNA, enveloped mainly by E proteins. Jaundice, ascites, easily bleeding/ bruising.
describe the clinical features and structure of influenza
influenza virus,- flu like symptoms outer host membrane sphere- protein M1 shell, 8 RNA single strands
describe the clinical features and structure of rotavirus
rota virus, 11 double stranded DNA segments non enveloped triple layered caspid. Icosahedral structure. Causes fever vomiting diarhoea, abdominal pain.
describe the clinical features and structure of measles
measles- fever, cough, runny nose + sore throat small white spots –> rash. Enveloped RNA single strand. Pleomorphic.
describe the clinical features and structure of mumps
Mumps- fever, muscle ache, fatigue, swollen saliva glands. structure: enveloped pleomorphic, single strand RNA. Helical nucleocaspid.
describe the clinical features and structure of rubella
rubella viruses,- fever, rash, coughing. Birth defects if acquired by pregnant women. Structure: icosahedral enveloped single strand RNA.
describe the clinical features and structure of enteroviruses
Enteroviruses- single strand RNA, icosahedral caspid. fever, runny nose, sneezing, cough, skin rash, mouth blisters, and body and muscle aches
describe the clinical features and structure of rhinovirus
rhinovirus - sore throat, runny nose, coughing, sneezing, watery eyes, headaches, and body aches. enveloped virus with a positive-sense single-stranded RNA
describe the clinical features and structure of adenovirus
Adenovirus- most commonly respiratory illness. Icosahedral, double stranded DNA, no envelope.
List factors that determine host susceptibility to viral infection
immuno supression
at risk activities for transmission
lifestyle (exposure, sexual activity)
age
nutritional status
pre-existing chronic diseases
genetics
Describe primary and secondary infection, re-infection and reactivation of infection and provide examples for each
primary- first encounter with virus
s’- an infection that occurs during of immediately after another infection.
re-infection: infected–> recovered–> infected. e.g rhinovirus
re-activation- doesn’t replicate for periods of time. then when immunosupressed will begin and cause disease. - varicella zoster